PERK
PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) inhibitors target the PERK pathway, which is involved in the cellular response to endoplasmic reticulum (ER) stress and the regulation of apoptosis. PERK plays a critical role in the unfolded protein response (UPR) by halting protein translation and promoting cell survival under stress conditions. However, prolonged PERK activation can lead to apoptosis. Inhibiting PERK can modulate these stress responses, making these inhibitors valuable in research on neurodegenerative diseases, cancer, and metabolic disorders. At CymitQuimica, we offer a range of high-quality PERK inhibitors to support your research in apoptosis, ER stress, and cellular homeostasis.
Found 23 products of "PERK"
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HC-5404-Fu
CAS:HC-5404-Fu is an inhibitor of PERK with anti-tumor activity. This compound inhibits the signaling pathway of the endoplasmic reticulum stress response. Additionally, HC-5404-Fu increases the sensitivity of renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). It holds potential for research into renal cell carcinoma, stomach cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors.Formula:C28H28F2N4O7Color and Shape:SolidMolecular weight:570.54eIF4E-IN-4
CAS:eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.Formula:C20H19ClN5O5PColor and Shape:SolidMolecular weight:475.822HC-5404
CAS:HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Formula:C24H24F2N4O3Purity:99.33%Color and Shape:SolidMolecular weight:454.47
