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PERK

PERK

PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) inhibitors target the PERK pathway, which is involved in the cellular response to endoplasmic reticulum (ER) stress and the regulation of apoptosis. PERK plays a critical role in the unfolded protein response (UPR) by halting protein translation and promoting cell survival under stress conditions. However, prolonged PERK activation can lead to apoptosis. Inhibiting PERK can modulate these stress responses, making these inhibitors valuable in research on neurodegenerative diseases, cancer, and metabolic disorders. At CymitQuimica, we offer a range of high-quality PERK inhibitors to support your research in apoptosis, ER stress, and cellular homeostasis.

Found 25 products of "PERK"

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  • Claturafenib
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    Claturafenib

    CAS:
    <p>Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.</p>
    Formula:C18H15Cl2F2N5O3S
    Purity:98.68% - 99.85%
    Color and Shape:Solid
    Molecular weight:490.31

    Ref: TM-T201081

  • HC-7366
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    HC-7366

    CAS:
    <p>HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.</p>
    Formula:C20H15ClF2N6O4S
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:508.89

    Ref: TM-T86497

  • HR-19011
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    HR-19011

    CAS:
    <p>HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP,antiproliferative.</p>
    Formula:C25H19F6N3O3
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:523.43

    Ref: TM-T63665

  • HC-5404-Fu
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    HC-5404-Fu

    CAS:
    <p>HC-5404-Fu is an inhibitor of PERK with anti-tumor activity. This compound inhibits the signaling pathway of the endoplasmic reticulum stress response. Additionally, HC-5404-Fu increases the sensitivity of renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). It holds potential for research into renal cell carcinoma, stomach cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors.</p>
    Formula:C28H28F2N4O7
    Color and Shape:Solid
    Molecular weight:570.54

    Ref: TM-T200111

  • HC-5404
    Targetmol
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    HC-5404

    CAS:
    <p>HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.</p>
    Formula:C24H24F2N4O3
    Purity:99.33%
    Color and Shape:Solid
    Molecular weight:454.47

    Ref: TM-T86545