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Caspase

Caspase

Caspase inhibitors are compounds that block the activity of caspases, a family of proteases that are central executors of apoptosis. Caspases cleave specific substrates within the cell to trigger the apoptotic process, leading to programmed cell death. Caspase inhibitors are used to study the mechanisms of apoptosis, as well as to prevent unwanted cell death in various research models. These inhibitors are also explored in therapeutic contexts to protect cells from apoptosis in diseases such as neurodegeneration. At CymitQuimica, we offer a wide range of high-quality caspase inhibitors to support your research in apoptosis, cell death, and related fields.

Found 154 products of "Caspase"

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  • Caspase-3-IN-2
    Targetmol
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    Caspase-3-IN-2

    CAS:
    Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.
    Formula:C10H6ClNO5
    Color and Shape:Solid
    Molecular weight:255.611

    Ref: TM-T205720

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  • CymitQuimica logo
    Targetmol
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    M826

    M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in
    Formula:C28H45N7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:575.7

    Ref: TM-T79497

    1mg
    1,431.00€
    5mg
    2,880.00€
    10mg
    3,718.00€
    25mg
    5,248.00€
    50mg
    6,803.00€
  • DeFer-2
    Targetmol
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    DeFer-2

    CAS:
    DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM). It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.
    Formula:C44H69N5O5S
    Color and Shape:Solid
    Molecular weight:780.11

    Ref: TM-T212081

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  • N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride
    Targetmol
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    N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride

    CAS:
    N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.
    Formula:C14H22Cl2N2O3S
    Molecular weight:369.31

    Ref: TM-T210015

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