LIM Kinase
LIM kinase inhibitors target LIM kinases, a family of enzymes involved in the regulation of the actin cytoskeleton and cell cycle progression. LIM kinases phosphorylate and inactivate cofilin, a protein that disassembles actin filaments, thus controlling cell shape, motility, and division. Inhibiting LIM kinases can affect these processes, leading to altered cell cycle dynamics and potential apoptosis. LIM kinase inhibitors are important tools in cancer research and the study of cell motility and invasion. At CymitQuimica, we provide a selection of high-quality LIM kinase inhibitors to support your research in cell signaling, cytoskeletal dynamics, and oncology.
Found 23 products for "LIM Kinase".
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R-10015
CAS:R-10015, potent LIMK inhibitor with 38 nM IC50 for LIMK1, targets ATP pocket, and serves as a broad-spectrum HIV antiviral.Formula:C20H19ClN6O2Purity:98.68%Color and Shape:SolidMolecular weight:410.857MDI-117740
MDI-117740 is a dual LIMK1/2 inhibitor. It demonstrates strong cellular target binding in HEK293 cells, inhibiting LIMK1 (pIC50=6.73) and LIMK2 (pIC50=7.18). In MDA-MB-231 cells, MDI-117740 shows significant anti-migratory activity. This compound is useful for studying diseases associated with LIMK dysregulation, such as cancer and neurodegenerative disorders.SM311
SM311 (Compound 10) is a potent, selective, and irreversible inhibitor of LIMK1, with an EC50 of 0.045 μM and over 30-fold selectivity for LIMK1 over LIMK2. It can inhibit cofilin phosphorylation and actin cytoskeleton regulation. SM311 shows potential for research in neurodegenerative disorders such as Fragile X Syndrome (FXS) and Alzheimer's disease, as well as in tumor invasion.Color and Shape:Odour SolidS3 Fragment
S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinaseFormula:C73H120N18O24S2Color and Shape:SolidMolecular weight:1697.97LX-7101 hydrochloride
CAS:LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.Formula:C23H29N7O3xHClPurity:97.61%Color and Shape:SolidMolecular weight:487.99THNAN69
THNAN69 is a potent chemical probe degrader specifically targeting LIMK2, with a DC50 value of 1 nM. This compound is useful for researching diseases driven by LIMK2 overexpression or dysregulation, such as cancer and ophthalmic conditions.BMS-3
CAS:BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Formula:C17H12Cl2F2N4OSPurity:99.31% - 99.81%Color and Shape:White SolidMolecular weight:429.271TH-257
CAS:TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).Formula:C24H26N2O3SPurity:98.23%Color and Shape:SolidMolecular weight:422.54TH-263
CAS:TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.Formula:C21H20N2O3SPurity:99.54%Color and Shape:SolidMolecular weight:380.46BMS-5
CAS:BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Formula:C17H14Cl2F2N4OSPurity:98.01% - 99.88%Color and Shape:SolidMolecular weight:431.29LIMK-IN-22j
CAS:LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Formula:C20H21BrN8Purity:99.16%Color and Shape:SolidMolecular weight:453.338T56-LIMKi
CAS:T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Formula:C19H14F3N3O3Purity:98.39% - 99.57%Color and Shape:SolidMolecular weight:389.328SR7826
CAS:SR7826 is a selective LIMK inhibitor.Formula:C22H21N5O2Purity:98%Color and Shape:SolidMolecular weight:387.43CRT-0105446
CAS:CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Formula:C20H18F3N3O2SPurity:98%Color and Shape:SolidMolecular weight:421.44TH470
CAS:TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,Formula:C30H31N5O5S2Color and Shape:SolidMolecular weight:605.73LIMK-IN-14
CAS:LIMK-IN-14 is an effective and selective inhibitor of LIMK.Formula:C22H27N7O3Purity:98%Color and Shape:SolidMolecular weight:437.49LIMK1 inhibitor BMS-4
CAS:BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.Formula:C23H23N7O2SColor and Shape:SolidMolecular weight:461.54CRT-0105950
CAS:CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Formula:C21H16ClN3OSPurity:99.78% - 99.91%Color and Shape:SolidMolecular weight:393.889LX7101
CAS:LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Formula:C23H29N7O3Purity:99.08%Color and Shape:SolidMolecular weight:451.5215LX7101 hydrochloride
CAS:LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.Formula:C23H29N7O3HClColor and Shape:SolidMolecular weight:488
