Ferroptosis
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides and iron-dependent oxidative stress. Unlike apoptosis, ferroptosis is not driven by caspases but rather by the failure of cellular antioxidant defenses, leading to cell death. Ferroptosis inhibitors and inducers are critical for studying this unique cell death pathway, which is implicated in various diseases, including cancer, neurodegeneration, and ischemia-reperfusion injury. At CymitQuimica, we offer a wide range of high-quality ferroptosis modulators to support your research in cell death mechanisms, oxidative stress, and disease pathology.
Found 227 products of "Ferroptosis"
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Erastin2
CAS:Erastin2 is an iron death inducer that induces cell death by binding to the lipophilic free radical trapping antioxidant ferrostatin-1 or the iron chelator DFO.
Formula:C36H35ClN4O4Purity:99.63%Color and Shape:SolidMolecular weight:623.14Utreloxastat
CAS:Utreloxastat (PTC857) is a novel 15-lipoxygenase inhibitor that can be used to study amyotrophic lateral sclerosis .Formula:C18H28O2Purity:99.95%Color and Shape:SolidMolecular weight:276.41Ref: TM-T60507
1mg96.00€5mg205.00€1mL*10mM (DMSO)224.00€10mg295.00€25mg505.00€50mg745.00€100mg1,305.00€200mg1,755.00€Deferitazole
CAS:Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator.Formula:C18H25NO7SPurity:99.48%Color and Shape:SolidMolecular weight:399.46viFSP1
CAS:viFSP1, a species-independent FSP1 inhibitor, effectively induces ferroptosis in FSP1-dependent cells by targeting the highly conserved NAD(P)H binding pocket of FSP1, directly inhibiting its activity. This action results in lipid peroxidation and exhibits anticancer activity [1].Formula:C16H17N3O3SColor and Shape:SolidMolecular weight:331.39Ogremorphin
CAS:Ogremorphin (GPR68-IN-1) is a potent inhibitor of GPR68, exhibiting an EC50 of 170 nM.it is utilized in the study of autoimmune chronic inflammatory diseases [1Formula:C21H17N3OSPurity:99.65% - 99.65%Color and Shape:SolidMolecular weight:359.44CP-24879 hydrochloride
CAS:CP-24879 HCl, a Δ5D/Δ6D dual-inhibitor, reduces liver lipid buildup and inflammation.
Formula:C11H18ClNOPurity:98.08%Color and Shape:SolidMolecular weight:215.72HAPSBC
CAS:HAPSBC, an S-benzyl iron chelator, modulates the intracellular distribution of ^59Fe [1].Formula:C15H15N3S2Color and Shape:SolidMolecular weight:301.43Cerivastatin
CAS:Cerivastatin is an HMG-CoA reductase inhibitor with anticancer and lipid-lowering effects and can be used to study primary hyperlipidemia.Formula:C26H34FNO5Purity:97.80% - 99.56%Color and Shape:SolidMolecular weight:459.55Docebenone
CAS:Docebenone is a selective and orally active inhibitor of 5-LO.Formula:C21H26O3Color and Shape:SolidMolecular weight:326.43Lepadin H
CAS:Lepadin H, a marine alkaloid and ferroptosis inducer, exhibits significant cytotoxicity by promoting p53 expression, escalating ROS production, and enhancingFormula:C26H45NO3Purity:98%Color and Shape:SolidMolecular weight:419.64Lepadin E
CAS:Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway.Formula:C26H47NO3Purity:98%Color and Shape:SolidMolecular weight:421.66GPX4 activator 2
CAS:GPX4 Activator 2 (Compound C3) serves as an activator of GPX4 and exhibits cardioprotective effects by inhibiting cellular iron death (ferroptosis) with an efficacy concentration (EC50) of 7.8 μM. It is used in the study of myocardial damage.Formula:C20H26N6O2SColor and Shape:SolidMolecular weight:414.52DL-Buthionine-(S,R)-sulfoximine hydrochloride
DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent and specific glutamylcysteine synthetase biosynthesis inhibitorFormula:C8H19ClN2O3SColor and Shape:SolidMolecular weight:258.77Artefenomel
CAS:Artefenomel (OZ439) is an orally active anti-malarial ozone analog with antiviral activity for the study of SARS-CoV-2 infections and malaria infections.Formula:C28H39NO5Color and Shape:SolidMolecular weight:469.61CAR-2
CAS:CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LD). It exhibits phototoxicity against breast cancer cells with an IC50 of 0.01-0.02 μM and demonstrates antitumor efficacy in a 4T1 xenograft mouse model.Formula:C27H23BF2I2N4O2Color and Shape:SolidMolecular weight:738.114Ferroptosis-IN-6
CAS:Ferroptosis-IN-6 is an efficient ferroptosis inhibitor, protecting cells from cell death induced by ferroptosis inducers, and inhibiting STY-BODIPY oxidation.Formula:C15H17NOPurity:99.84%Color and Shape:SolidMolecular weight:227.3Ref: TM-T86417
1mg57.00€5mg120.00€1mL*10mM (DMSO)133.00€10mg187.00€25mg376.00€50mg605.00€100mg938.00€Ferroptosis-IN-18
CAS:Ferroptosis-IN-18 (51) is a phenothiazine derivative known for its potent anti-ferroptotic and antioxidant properties. It is useful for research related to intracerebral hemorrhage (ICH).Formula:C25H27N3SColor and Shape:SolidMolecular weight:401.567GPX4-IN-3
CAS:GPX4-IN-3 (26a) is a potent GPX4 inhibitor, inducing selective ferroptosis with 71.7% inhibition at 1 μM.Formula:C29H24ClN3O3SColor and Shape:SolidMolecular weight:530.04Nur77 agonist-1
CAS:Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. It induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, while decreasing GPX4 protein expression. Nur77 agonist-1 binds with affinity to the ligand binding domain of Nur77, with a KD of 13.80 μM. It demonstrates significant antiproliferative activity against various breast cancer cells (IC50: 2.15-3.26 μM) and exhibits low cytotoxicity towards normal cells. This compound is useful for breast cancer research.Formula:C24H18ClN5O2Color and Shape:SolidMolecular weight:443.885GPX4-IN-13
CAS:GPX4-IN-13 (compound 16), a GPX4 inhibitor, exhibits anticancer properties by diminishing the expression of GPX4, thereby reducing thyroid cell proliferation and inducing ferroptosis. Additionally, this compound effectively inhibits the growth of three distinct thyroid cancer cell lines: N-thy-ori-3-1 (IC 50 =8.39 μM), MDA-T32 (IC 50 =10.28 μM), and MDA-T41 (IC 50 =8.18 μM).Formula:C23H15NO3Color and Shape:SolidMolecular weight:353.37
