CDK
CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.
Found 546 products of "CDK"
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MLS-573151
CAS:MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Formula:C21H19N3O2SPurity:98.80%Color and Shape:SolidMolecular weight:377.46Ref: TM-T22106
2mg34.00€5mg50.00€10mg86.00€25mg161.00€50mg245.00€100mg363.00€200mg515.00€1mL*10mM (DMSO)55.00€LY2857785
CAS:LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).Formula:C26H36N6OPurity:99.68%Color and Shape:Solid PowderMolecular weight:448.6Ref: TM-TQ0060
1mg50.00€2mg71.00€5mg105.00€10mg170.00€25mg334.00€50mg537.00€100mg863.00€1mL*10mM (DMSO)117.00€Desmethylglycitein
CAS:Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFormula:C15H10O5Purity:97.93%Color and Shape:SolidMolecular weight:270.24Dalpiciclib
CAS:Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.
Formula:C25H30N6O2Purity:99.69%Color and Shape:SolidMolecular weight:446.54LY3143921
CAS:LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Formula:C16H12FN5OColor and Shape:SolidMolecular weight:309.31-NM-PP1
CAS:1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.Formula:C20H21N5Purity:98% - 98.93%Color and Shape:White Cyrstalline SolidMolecular weight:331.41Ref: TM-T2153
1mg48.00€2mg63.00€5mg84.00€10mg132.00€25mg271.00€50mg505.00€100mg668.00€1mL*10mM (DMSO)90.00€SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Formula:C15H18BrN7Purity:99.88%Color and Shape:SolidMolecular weight:376.25Ref: TM-T3700
1mg50.00€2mg66.00€5mg90.00€10mg146.00€25mg250.00€50mg403.00€100mg593.00€1mL*10mM (DMSO)108.00€CDK9-IN-30
CAS:CDK9-IN-30 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.Formula:C16H20FNO3Purity:99.75%Color and Shape:SolidMolecular weight:293.33Ref: TM-T9632
1mg56.00€5mg119.00€10mg187.00€25mg316.00€50mg472.00€100mg658.00€500mg1,378.00€1mL*10mM (DMSO)114.00€BUR1
CAS:BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.Formula:C16H17N5Purity:90%Color and Shape:SolidMolecular weight:279.34CC-671
CAS:CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.Formula:C28H28N6O4Purity:98.66% - 98.8%Color and Shape:SolidMolecular weight:512.56Ref: TM-T4482
1mg50.00€5mg105.00€10mg170.00€25mg340.00€50mg512.00€100mg733.00€500mg1,513.00€1mL*10mM (DMSO)120.00€BS194
CAS:BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.Formula:C20H27N5O3Purity:99.85%Color and Shape:SolidMolecular weight:385.46PF-562271 besylate
CAS:PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.Formula:C21H20F3N7O3S·C6H6O3SPurity:97.65% - 99.01%Color and Shape:SolidMolecular weight:665.66Ref: TM-T6177
1mg35.00€5mg74.00€10mg94.00€25mg138.00€50mg198.00€100mg296.00€200mg427.00€1mL*10mM (DMSO)89.00€Palbociclib
CAS:Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Formula:C24H29N7O2Purity:98% - 99.9%Color and Shape:SolidMolecular weight:447.53Purvalanol A
CAS:Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.Formula:C19H25ClN6OPurity:98.13% - 99.68%Color and Shape:PowderMolecular weight:388.89Bromosporine
CAS:Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.Formula:C17H20N6O4SPurity:99.65% - 99.79%Color and Shape:SolidMolecular weight:404.44Ref: TM-T6255
1mg44.00€2mg57.00€5mg93.00€10mg133.00€25mg260.00€50mg416.00€100mg665.00€200mg888.00€1mL*10mM (DMSO)92.00€Voruciclib
CAS:Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.Formula:C22H19ClF3NO5Purity:99.89% - 99.99%Color and Shape:SolidMolecular weight:469.84THZ1
CAS:THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.Formula:C31H28ClN7O2Purity:97.42% - 99.27%Color and Shape:SolidMolecular weight:566.05PF-562271 hydrochloride
CAS:PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK.Formula:C21H20F3N7O3SHClPurity:97.08%Color and Shape:SolidMolecular weight:543.95SEL120-34A HCl
CAS:SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectivelyFormula:C15H19Br2ClN4Purity:98.13% - 98.47%Color and Shape:SolidMolecular weight:450.6SB1317 hydrochloride (1204918-72-8(free base))
SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).Formula:C23H25ClN4OPurity:99.84%Color and Shape:SolidMolecular weight:408.92Ref: TM-T4227
1mg50.00€2mg65.00€5mg107.00€10mg170.00€25mg306.00€50mg371.00€100mg553.00€1mL*10mM (DMSO)117.00€
