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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • BI-1347
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    BI-1347

    CAS:
    <p>BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.</p>
    Formula:C22H20N4O
    Purity:96.7% - 99.63%
    Color and Shape:Solid
    Molecular weight:356.42

    Ref: TM-T5405

  • SRI-29329
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    SRI-29329

    CAS:
    <p>SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).</p>
    Formula:C20H26ClN7
    Purity:99.18%
    Color and Shape:Solid
    Molecular weight:399.92

    Ref: TM-T8801

  • NSC23005
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    NSC23005

    CAS:
    <p>NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).</p>
    Formula:C13H17NO4S
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:283.34

    Ref: TM-T3590

  • AT7519
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    AT7519

    CAS:
    <p>AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.</p>
    Formula:C16H17Cl2N5O2
    Purity:98.88% - 99.65%
    Color and Shape:Solid
    Molecular weight:382.24

    Ref: TM-T6205

  • (E/Z)-TG003
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    (E/Z)-TG003

    CAS:
    <p>(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.</p>
    Formula:C13H15NO2S
    Purity:98% - 99.04%
    Color and Shape:Solid
    Molecular weight:249.33

    Ref: TM-T1901

  • TP-353
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    TP-353

    CAS:
    <p>TP-353 (EOS-61973) is a CDK7 inhibitor.</p>
    Formula:C35H30FNO3
    Purity:99.12%
    Color and Shape:Solid
    Molecular weight:531.62

    Ref: TM-T22440

  • Trilaciclib
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    Trilaciclib

    CAS:
    <p>Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. enhances antitumour immunity.</p>
    Formula:C24H30N8O
    Purity:99.624%
    Color and Shape:Solid
    Molecular weight:446.55

    Ref: TM-T13202L

  • AZ5576
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    AZ5576

    CAS:
    <p>AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].</p>
    Formula:C21H24FN3O3
    Purity:99.88%
    Color and Shape:Soild
    Molecular weight:385.43

    Ref: TM-T60152

  • CDK12-IN-5
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    CDK12-IN-5

    CAS:
    <p>CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.</p>
    Formula:C18H15F5N8O
    Purity:99.37%
    Color and Shape:Solid
    Molecular weight:454.36

    Ref: TM-T40290

  • LSN2839567
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    LSN2839567

    CAS:
    <p>LSN2839567 (Abemaciclib metabolite M2) is a CDK4 and CDK6 inhibitor with anticancer activity, inhibits CDK9, and can be used in breast cancer research.</p>
    Formula:C25H28F2N8
    Purity:99.14%
    Color and Shape:Solid
    Molecular weight:478.54

    Ref: TM-T10220

  • (R)-(+)-O-Demethylbuchenavianine
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    (R)-(+)-O-Demethylbuchenavianine

    CAS:
    <p>(R)-(+)-O-Demethylbuchenavianine is a cyclin-dependent kinase (CDK) inhibitor. It inhibits CDK1, CDK5, glycogen synthase kinase 3 (GSK3), cdc2-like kinase (CLK1), and dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) with IC50 values of 1.1 μM, 0.95 μM, &gt;10 μM, &gt;10 μM, and &gt;10 μM, respectively.</p>
    Formula:C21H21NO4
    Color and Shape:Solid
    Molecular weight:351.40

    Ref: TM-T88435

  • Riviciclib hydrochloride
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    Riviciclib hydrochloride

    CAS:
    <p>Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.</p>
    Formula:C21H20ClNO5·HCl
    Purity:99.51%
    Color and Shape:Solid
    Molecular weight:438.3

    Ref: TM-T6924

  • XL413
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    XL413

    CAS:
    <p>XL-413 is an oral CDC7 kinase inhibitor, potentially blocking DNA replication, mitosis, and cancer cell growth.</p>
    Formula:C14H12ClN3O2
    Purity:98.40% - >99.99%
    Color and Shape:Solid
    Molecular weight:289.72

    Ref: TM-T3352

  • MFH290
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    MFH290

    CAS:
    <p>MFH290 is a selective CDK12/13 inhibitor, covalently bonding with CDK12 Cys-1039, blocks Pol II CTD phosphorylation, and enhances olaparib's efficacy.</p>
    Formula:C26H31N5O3S2
    Color and Shape:Solid
    Molecular weight:525.69

    Ref: TM-T69931

  • CDK2-IN-13
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    CDK2-IN-13

    CAS:
    <p>CDK2-IN-13: Potent CDK2 inhibitor, arrests cell cycle, induces apoptosis, IC50=12 µM, used in cancer research.</p>
    Formula:C13H12ClN5
    Color and Shape:Soild
    Molecular weight:273.72

    Ref: TM-T60154

  • CDK8-IN-4
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    CDK8-IN-4

    CAS:
    <p>CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).</p>
    Formula:C20H18N4O
    Color and Shape:Solid
    Molecular weight:330.38

    Ref: TM-T17305

  • CDK12-IN-3
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    CDK12-IN-3

    CAS:
    <p>CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.</p>
    Formula:C23H28F2N8O
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:470.52

    Ref: TM-T14990

  • Cdc7-IN-5
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    Cdc7-IN-5

    CAS:
    <p>Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.</p>
    Formula:C25H23N3O5
    Purity:97.15%
    Color and Shape:Solid
    Molecular weight:445.47

    Ref: TM-T10727

  • Cdc7-IN-9
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    Cdc7-IN-9

    CAS:
    <p>Cdc7-IN-9 can be used for the research of cancer which is a potent inhibitor of Cdc7 [1].</p>
    Formula:C15H17N5OS
    Color and Shape:Solid
    Molecular weight:315.39

    Ref: TM-T60815

  • SNX2-1-108
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    SNX2-1-108

    CAS:
    <p>SNX2-1-108 is a selective CDK8 and CDK19 inhibitor.</p>
    Formula:C21H16N4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:324.38

    Ref: TM-T24811