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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • Metralindole HCl

    CAS:
    <p>Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.</p>
    Formula:C15H18ClN3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:291.78
  • CDK7-IN-15

    CAS:
    <p>CDK7-IN-15, a pyrimidine-based potent CDK7 inhibitor, shows promise for various cancers with defective transcription.</p>
    Formula:C21H24F4N6OS
    Color and Shape:Solid
    Molecular weight:484.51
  • BAY-958

    CAS:
    <p>BAY-958 is a potent and selective inhibitor of PTEFb/CDK9.</p>
    Formula:C17H16FN5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:389.4
  • EGFR/CDK2-IN-1

    CAS:
    <p>EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application in</p>
    Formula:C19H12BrClO2
    Color and Shape:Solid
    Molecular weight:387.65
  • CDK7-IN-10

    CAS:
    <p>CDK7-IN-10: CDK7 inhibitor, IC50&lt;100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)</p>
    Formula:C29H35N7O3
    Color and Shape:Solid
    Molecular weight:529.63
  • CDK7-IN-16

    CAS:
    <p>CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.</p>
    Formula:C19H21F3N6O2S
    Color and Shape:Solid
    Molecular weight:454.47
  • Ipivivint

    CAS:
    <p>Ipivivint: orally active, potent CLK inhibitor; hinders CLK1, CLK2, &amp; CLK3; curbs Wnt signaling &amp; SRSF phosphorylation for cancer research.</p>
    Formula:C26H21FN8
    Color and Shape:Solid
    Molecular weight:464.5
  • NSC 693868

    CAS:
    <p>CDKs and GSK-3 inhibitor</p>
    Formula:C9H7N5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:185.19
  • Atuveciclib S-Enantiomer

    CAS:
    <p>Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.</p>
    Formula:C18H18FN5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:387.43
  • CDK8-IN-6

    CAS:
    <p>CDK8-IN-6 (compound 9) is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 13 nM), CDK8-IN-6 showed potential research value in AML cancers.</p>
    Formula:C26H37ClN2
    Color and Shape:Solid
    Molecular weight:413.04
  • CDK4/6-IN-14

    CAS:
    <p>CDK4/6-IN-14: potent CDK4/6 inhibitor, IC50s 10/16 nM, &gt;60-fold selectivity over CDKs 1/2/7/9, selective across 205 kinases.</p>
    Formula:C24H27ClFN7O
    Color and Shape:Solid
    Molecular weight:483.97
  • KH-CB19

    CAS:
    <p>KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).</p>
    Formula:C15H13Cl2N3O2
    Color and Shape:Solid
    Molecular weight:338.19
  • Cdc7-IN-14

    CAS:
    <p>Cdc7-IN-14 (compound 82) is a potent CDC7 inhibitor with an IC50 &lt; 1 nM, promising for cancer research.</p>
    Formula:C18H20N4O2S
    Color and Shape:Solid
    Molecular weight:356.44
  • CDK9-IN-15

    CAS:
    <p>CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.</p>
    Formula:C16H11N3OS
    Purity:97.24%
    Color and Shape:Solid
    Molecular weight:293.34
  • CDK-IN-10

    CAS:
    <p>CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.</p>
    Formula:C18H18N4O2
    Purity:97.07%
    Color and Shape:Solid
    Molecular weight:322.36
  • CLK1-IN-2


    <p>CLK1-IN-2: Metabolically stable, Clk1-selective inhibitor; IC50=1.7nM; useful in tumor, Duchenne MD, HIV-1, influenza research.</p>
    Formula:C16H12Cl2N2O2S
    Color and Shape:Solid
    Molecular weight:367.25
  • XIE18-6

    CAS:
    <p>XIE18-6 is a novel INK4C inhibitor that blocks p18 activity and promotes ex vivo expansion of human and murine hematopoietic stem cells.</p>
    Formula:C18H15NO6S
    Purity:99.712%
    Color and Shape:Solid
    Molecular weight:373.38
  • NSC 625987

    CAS:
    <p>Cyclin-dependent kinase (cdk) 4 inhibitor</p>
    Formula:C15H13NO2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:271.33
  • ARN22089

    CAS:
    <p>ARN22089 is an oral active CDC42 GTPase interaction inhibitor that blocks tumour growth in BRAF mutant mouse melanoma models and PDXs in vivo.</p>
    Formula:C23H27N5
    Purity:98.37%
    Color and Shape:Solid
    Molecular weight:373.49
  • CDK8/19-IN-51

    CAS:
    <p>CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.</p>
    Formula:C23H22N6O2
    Purity:98.65% - 99.62%
    Color and Shape:Soild
    Molecular weight:414.46