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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 501 products of "CDK"

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  • K 00546

    CAS:
    <p>K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).</p>
    Formula:C15H13F2N7O2S2
    Purity:99.12%
    Color and Shape:Solid
    Molecular weight:425.44
  • SNX2-1-108

    CAS:
    <p>SNX2-1-108 is a selective CDK8 and CDK19 inhibitor.</p>
    Formula:C21H16N4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:324.38
  • Metralindole HCl

    CAS:
    <p>Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.</p>
    Formula:C15H18ClN3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:291.78
  • CDK8-IN-7

    CAS:
    <p>CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.</p>
    Formula:C30H40N2
    Color and Shape:Solid
    Molecular weight:428.65
  • BAY-958

    CAS:
    <p>BAY-958 is a potent and selective inhibitor of PTEFb/CDK9.</p>
    Formula:C17H16FN5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:389.4
  • Atuveciclib S-Enantiomer

    CAS:
    <p>Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.</p>
    Formula:C18H18FN5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:387.43
  • Cdc7-IN-15

    CAS:
    <p>Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].</p>
    Formula:C12H14N4OS
    Color and Shape:Solid
    Molecular weight:262.33
  • CP681301

    CAS:
    <p>CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.</p>
    Formula:C17H22N4O
    Color and Shape:Solid
    Molecular weight:298.38
  • (E/Z)-BIO-acetoxime

    CAS:
    <p>(E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.</p>
    Formula:C18H12BrN3O3
    Color and Shape:Solid
    Molecular weight:398.21
  • CDK-IN-10

    CAS:
    <p>CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.</p>
    Formula:C18H18N4O2
    Purity:97.07%
    Color and Shape:Solid
    Molecular weight:322.36
  • CDK8-IN-4

    CAS:
    <p>CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).</p>
    Formula:C20H18N4O
    Color and Shape:Solid
    Molecular weight:330.38
  • CDK12-IN-3

    CAS:
    <p>CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.</p>
    Formula:C23H28F2N8O
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:470.52
  • NSC 693868

    CAS:
    <p>CDKs and GSK-3 inhibitor</p>
    Formula:C9H7N5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:185.19
  • P18IN003

    CAS:
    <p>P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of</p>
    Formula:C17H16N2O3
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:296.32
  • CDK7-IN-15

    CAS:
    <p>CDK7-IN-15, a pyrimidine-based potent CDK7 inhibitor, shows promise for various cancers with defective transcription.</p>
    Formula:C21H24F4N6OS
    Color and Shape:Solid
    Molecular weight:484.51
  • Cdc7-IN-1

    CAS:
    <p>Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.</p>
    Formula:C21H16ClN3O4
    Color and Shape:Solid
    Molecular weight:409.82
  • BS-181

    CAS:
    <p>BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); &gt;40-fold selective for CDK7 than CDK1/2/4/5/6/9.</p>
    Formula:C22H32N6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:380.53
  • CLK1/2-IN-3

    CAS:
    <p>CLK1/2-IN-3 (Cpd-3) is a CLK1 and CLK2 inhibitor with antiproliferative activity that inhibits the activity of CLK and SRPK.</p>
    Formula:C21H21N5O2
    Purity:99.04%
    Color and Shape:Solid
    Molecular weight:375.42
  • CDK7-IN-10

    CAS:
    <p>CDK7-IN-10: CDK7 inhibitor, IC50&lt;100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)</p>
    Formula:C29H35N7O3
    Color and Shape:Solid
    Molecular weight:529.63
  • CGP60474

    CAS:
    <p>CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.</p>
    Formula:C18H18ClN5O
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:355.82