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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • CDK-IN-2
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    CDK-IN-2

    CAS:
    <p>CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: &lt;8 nM).</p>
    Formula:C18H19ClFN3O2
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:363.81

    Ref: TM-TQ0078

  • 9-Isopropylolomoucine
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    9-Isopropylolomoucine

    CAS:
    <p>9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.</p>
    Formula:C17H22N6O
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:326.4

    Ref: TM-T23589

  • CDK8-IN-1
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    CDK8-IN-1

    CAS:
    <p>CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).</p>
    Formula:C11H8F3N3O
    Purity:98.48%
    Color and Shape:Solid
    Molecular weight:255.2

    Ref: TM-T10740

  • Cdc7-IN-7c
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    Cdc7-IN-7c

    CAS:
    <p>Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.</p>
    Formula:C15H17N5OS
    Purity:98.19% - 99.22%
    Color and Shape:Solid
    Molecular weight:315.39

    Ref: TM-T23867

  • SEL120-34A
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    SEL120-34A

    CAS:
    <p>SEL120-34A inhibits CDK8 (IC50: 4.4 nM) &amp; CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.</p>
    Formula:C15H18Br2N4
    Purity:99.764% - 99.84%
    Color and Shape:Solid
    Molecular weight:414.14

    Ref: TM-T10744

  • CDK4/6/1 Inhibitor
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    CDK4/6/1 Inhibitor

    CAS:
    <p>CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).</p>
    Formula:C28H30F2N6
    Purity:99.26% - 99.72%
    Color and Shape:Solid
    Molecular weight:488.57

    Ref: TM-T10735

  • BML-259
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    BML-259

    CAS:
    <p>BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.</p>
    Formula:C14H16N2OS
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:260.35

    Ref: TM-T36964

  • dCeMM2
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    dCeMM2

    CAS:
    <p>dCeMM2 degrades glue by promoting CDK12-cyclin K ubiquitination and degradation via CRL4B ligase interaction.</p>
    Formula:C16H11ClN6OS
    Purity:99.68%
    Color and Shape:Solid
    Molecular weight:370.82

    Ref: TM-T61477

  • Cdk2 Inhibitor II
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    Cdk2 Inhibitor II

    CAS:
    <p>Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.</p>
    Formula:C14H11BrN4O3S
    Purity:97.07%
    Color and Shape:Solid
    Molecular weight:395.23

    Ref: TM-T36933

  • Abemaciclib metabolite M20
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    Abemaciclib metabolite M20

    CAS:
    <p>Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。</p>
    Formula:C27H32F2N8O
    Purity:98.1% - 99.08%
    Color and Shape:Solid
    Molecular weight:522.59

    Ref: TM-T10738

  • SHP2/CDK4-IN-1
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    SHP2/CDK4-IN-1

    CAS:
    <p>SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.</p>
    Formula:C33H35ClF2N10OS
    Color and Shape:Solid
    Molecular weight:693.21

    Ref: TM-T72836

  • CDK-IN-11
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    CDK-IN-11

    CAS:
    <p>CDK-IN-11, a heterocyclic compound, promotes cardiomyocyte maturation [1].</p>
    Formula:C25H21BrN4O2
    Color and Shape:Solid
    Molecular weight:489.36

    Ref: TM-T84917

  • CDK/HDAC-IN-3
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    CDK/HDAC-IN-3

    CAS:
    <p>CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3,</p>
    Formula:C24H18Cl2N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:509.34

    Ref: TM-T78906

  • Cdk4 Inhibitor
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    Cdk4 Inhibitor

    CAS:
    <p>PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 &lt; 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.</p>
    Formula:C20H10BrN3O2
    Color and Shape:Solid
    Molecular weight:404.2

    Ref: TM-T84413

  • EHT 5372
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    EHT 5372

    CAS:
    <p>EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.</p>
    Formula:C17H11Cl2N5OS
    Color and Shape:Solid
    Molecular weight:404.27

    Ref: TM-T61985

  • Nε-(1-Carboxyethyl)-L-lysine
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    Nε-(1-Carboxyethyl)-L-lysine

    CAS:
    <p>Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.</p>
    Formula:C9H18N2O4
    Color and Shape:Solid
    Molecular weight:218.25

    Ref: TM-T85157

  • Lerociclib
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    Lerociclib

    CAS:
    <p>Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.</p>
    Formula:C26H34N8O
    Purity:99%
    Color and Shape:Solid
    Molecular weight:474.6

    Ref: TM-T11345

  • CDK8-IN-3
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    CDK8-IN-3

    CAS:
    <p>CDK8-IN-3 is an inhibitor of CDK8.</p>
    Formula:C22H23N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:389.45

    Ref: TM-T14917

  • CDK9-IN-29
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    CDK9-IN-29

    CAS:
    <p>CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.</p>
    Formula:C29H33F2N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:553.6

    Ref: TM-T82757

  • IIIM-290
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    IIIM-290

    CAS:
    <p>IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).</p>
    Formula:C23H21Cl2NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:462.32

    Ref: TM-T11632