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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • CCT-251921

    CAS:
    <p>CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).</p>
    Formula:C21H23ClN6O
    Purity:99.07%
    Color and Shape:Solid
    Molecular weight:410.9
  • CDK9-IN-8

    CAS:
    <p>CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).</p>
    Formula:C31H32FN7O3
    Purity:99.54%
    Color and Shape:Solid
    Molecular weight:569.63
  • QR-6401

    CAS:
    <p>QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/</p>
    Formula:C19H23N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:369.42
  • Tacaciclib

    CAS:
    <p>Tacaciclib is a cyclin-dependent kinase (CDK) inhibitor with observed antineoplastic activity [1].</p>
    Formula:C30H36N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:528.65
  • Mevociclib

    CAS:
    <p>Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.</p>
    Formula:C31H35ClN8O2
    Purity:98.02% - 98.02%
    Color and Shape:Solid
    Molecular weight:587.11
  • Palbociclib orotate

    CAS:
    <p>Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.</p>
    Formula:C29H33N9O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:603.63
  • KM05382

    CAS:
    <p>KM05382 inhibits CDK9 and the transcription of GAPDH.</p>
    Formula:C20H19ClN2O3S2
    Color and Shape:Solid
    Molecular weight:434.96
  • CDK4-IN-2

    CAS:
    <p>CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].</p>
    Formula:C22H26F2N6O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:508.54
  • DCB-3503

    CAS:
    <p>DCB-3503, a tylophorine analog, may fight cancer and aid immunosuppression by hindering protein synthesis and modulating HSC70 ATPase function.</p>
    Formula:C24H27NO5
    Color and Shape:Solid
    Molecular weight:409.47
  • LDC3140

    CAS:
    <p>LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).</p>
    Formula:C23H33N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:423.55
  • Leucettinib-92

    CAS:
    <p>Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM</p>
    Formula:C21H22N4OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:378.49
  • CDK9-IN-9

    CAS:
    <p>CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).</p>
    Formula:C22H23F2N5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:459.51
  • (2S,3R)-Voruciclib

    CAS:
    <p>(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.</p>
    Formula:C22H19ClF3NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:469.84
  • CDK9-IN-2

    CAS:
    <p>CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.</p>
    Formula:C23H25ClFN5
    Purity:99%
    Color and Shape:Solid
    Molecular weight:425.93
  • CDK7-IN-14

    CAS:
    <p>CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).</p>
    Formula:C22H24F3N6OP
    Color and Shape:Solid
    Molecular weight:476.43
  • 5-Iodo-indirubin-3'-monoxime

    CAS:
    <p>5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s</p>
    Formula:C16H10IN3O2
    Color and Shape:Solid
    Molecular weight:403.17
  • NU6300

    CAS:
    <p>NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties and also functions as a GSDMD (Gasdermin D) inhibitor.</p>
    Formula:C20H23N5O3S
    Purity:96.08%
    Color and Shape:Solid
    Molecular weight:413.49
  • Voruciclib hydrochloride

    CAS:
    <p>Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).</p>
    Formula:C22H20Cl2F3NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:506.3
  • PF-6808472

    CAS:
    <p>PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.</p>
    Formula:C25H27FN8O3S
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:538.6
  • CDK7-IN-22

    CAS:
    <p>CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].</p>
    Formula:C22H25F3N6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:430.47