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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • Senexin C
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    Senexin C

    CAS:
    <p>Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.</p>
    Formula:C28H27N5O
    Purity:98.06%
    Color and Shape:Solid
    Molecular weight:449.55

    Ref: TM-T62702

  • Bisindolylmaleimide X hydrochloride
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    Bisindolylmaleimide X hydrochloride

    CAS:
    <p>Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).</p>
    Formula:C26H25ClN4O2
    Purity:99.23%
    Color and Shape:Solid
    Molecular weight:460.96

    Ref: TM-T10550

  • Cdc7-IN-7
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    Cdc7-IN-7

    CAS:
    <p>Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.</p>
    Formula:C21H22N4O5
    Purity:98.78%
    Color and Shape:Solid
    Molecular weight:410.42

    Ref: TM-T10729

  • CDK9-IN-23
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    CDK9-IN-23

    CAS:
    <p>CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].</p>
    Formula:C22H25ClN4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:428.91

    Ref: TM-T79037

  • Senexin A hydrochloride
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    Senexin A hydrochloride

    CAS:
    <p>Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].</p>
    Formula:C17H15ClN4
    Color and Shape:Solid
    Molecular weight:310.78

    Ref: TM-T84893

  • CDK9-IN-19
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    CDK9-IN-19

    CAS:
    <p>CDK9-IN-19: Potent CDK9 inhibitor, anti-cancer, moderate pharmacokinetics, low hERG impact, effective in AML research.</p>
    Formula:C26H22F2N4O5
    Color and Shape:Solid
    Molecular weight:508.47

    Ref: TM-T63490

  • Riviciclib
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    Riviciclib

    CAS:
    <p>Riviciclib, a CDK inhibitor (CDK9/T1, CDK4/D1, CDK1/B), has IC50s: 20, 63, 79 nM respectively, and fights cisplatin-resistant tumors.</p>
    Formula:C21H20ClNO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:401.84

    Ref: TM-T12737

  • ML 315 hydrochloride
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    ML 315 hydrochloride

    CAS:
    <p>ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].</p>
    Formula:C18H14Cl3N3O2
    Color and Shape:Solid
    Molecular weight:410.682

    Ref: TM-T84712

  • (S)-Cdc7-IN-18
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    (S)-Cdc7-IN-18

    CAS:
    <p>'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'</p>
    Formula:C19H21N5OS
    Color and Shape:Solid
    Molecular weight:367.47

    Ref: TM-T61435

  • CymitQuimica logo
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    CDK7-IN-25

    CAS:
    <p>CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].</p>
    Formula:C33H32N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:560.65

    Ref: TM-T79881

  • Inixaciclib
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    Inixaciclib

    CAS:
    <p>Inixaciclib is a potent CDK inhibitor, can be used to research anticancer.</p>
    Formula:C26H30F2N6O
    Color and Shape:Solid
    Molecular weight:480.55

    Ref: TM-T69662

  • SZ-015268
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    SZ-015268

    CAS:
    <p>SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.</p>
    Formula:C25H38N8O3
    Color and Shape:Solid
    Molecular weight:498.62

    Ref: TM-T63383

  • CDK4/6-IN-15
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    CDK4/6-IN-15

    CAS:
    <p>CDK4/6-IN-15: Oral, selective CDK4/6 inhibitor, halts cancer cell growth, G1 arrest, suppresses Rb phosphorylation.</p>
    Formula:C21H27FN8S
    Color and Shape:Solid
    Molecular weight:442.56

    Ref: TM-T72928

  • CDK4/6-IN-17
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    CDK4/6-IN-17

    CAS:
    <p>CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.</p>
    Formula:C27H28F4N8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:540.56

    Ref: TM-T79112

  • Cdc7-IN-12
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    Cdc7-IN-12

    CAS:
    <p>Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).</p>
    Formula:C16H14N2O2S
    Color and Shape:Solid
    Molecular weight:298.36

    Ref: TM-T60659

  • Xylocydine
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    Xylocydine

    CAS:
    <p>Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.</p>
    Formula:C12H14BrN5O5
    Color and Shape:Solid
    Molecular weight:388.17

    Ref: TM-T68875

  • CF53
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    CF53

    CAS:
    <p>CF53: potent, selective oral BET inhibitor; Ki &lt;1 nM, Kd 2.2 nM, IC50 2 nM for BRD4 BD1; high affinity for BRD2/3/4/BRDT; effective anti-tumor agent.</p>
    Formula:C24H25N7O2
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:443.5

    Ref: TM-T10773

  • Cdk1/2 Inhibitor III
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    Cdk1/2 Inhibitor III

    CAS:
    <p>Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.</p>
    Formula:C15H13F2N7O2S2
    Purity:99.07%
    Color and Shape:Solid
    Molecular weight:425.44

    Ref: TM-T14914

  • (R)-Simurosertib
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    (R)-Simurosertib

    CAS:
    <p>(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.</p>
    Formula:C17H19N5OS
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:341.43

    Ref: TM-T12642

  • XY028-140
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    XY028-140

    CAS:
    <p>XY028-140 is a selective CDK4/6 inhibitor and degrader, acting via PROTAC with ligands for Cereblon and CDK in cancer cells.</p>
    Formula:C39H40N10O7
    Purity:98.59%
    Color and Shape:Solid
    Molecular weight:760.8

    Ref: TM-T36694