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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 500 products of "CDK"

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  • CDK4/6-IN-5
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    CDK4/6-IN-5

    CAS:
    <p>CDK4/6-IN-5 inhibits CDK4/6; Ki: 0.2 nM (CDK4/D1) &amp; 4.4 nM (CDK6/D3). (WO2019207463A1, A93)</p>
    Formula:C22H28ClFN6O4S
    Color and Shape:Solid
    Molecular weight:527.01

    Ref: TM-T39956

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    Multi-target kinase inhibitor 2

    <p>Compound 5K (Multi-target kinase inhibitor 2) is a multi-targeted kinase inhibitor demonstrating activity against EGFR, Her2, VEGFR2, and CDK2 with IC50 values</p>
    Purity:98%
    Color and Shape:Odour Solid

    Ref: TM-T81739

  • CDK12-IN-6
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    CDK12-IN-6

    CAS:
    <p>CDK12-IN-6, a pyrazolotriazine, strongly inhibits CDK12 (IC50 1.19 μM at 2 mM ATP), but not CDK2/Cyclin E or CDK9/Cyclin T1 (both IC50 &gt;20 μM).</p>
    Formula:C20H21F2N9
    Color and Shape:Solid
    Molecular weight:425.448

    Ref: TM-T40289

  • TMX-2138
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    TMX-2138

    CAS:
    <p>TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1/cyclinB, 10.9 nM for CDK2/cyclinA, 7.0 nM for CDK5/p25, and 25.7 nM for CDK9/cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.</p>
    Formula:C40H43BrFN9O11S
    Color and Shape:Solid
    Molecular weight:956.791

    Ref: TM-T204343

  • CDK9 inhibitor HH1
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    CDK9 inhibitor HH1

    CAS:
    <p>CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.</p>
    Formula:C13H15N3OS
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:261.34

    Ref: TM-T118066

  • Abemaciclib metabolite M18
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    Abemaciclib metabolite M18

    CAS:
    <p>Abemaciclib M18 (LSN3106729), a potent CDK inhibitor with antitumor action, used in a PROTAC to degrade CDK4/6.</p>
    Formula:C25H28F2N8O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:494.54

    Ref: TM-T73909

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    PROTAC CDK9 degrader-8

    <p>PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].</p>
    Formula:C44H52Cl2N10O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:903.85

    Ref: TM-T78928

  • CymitQuimica logo
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    CDK9-IN-25

    <p>CDK9-IN-25 (compound 4a), an imidazopyrazine derivative, functions as a CDK9 inhibitor with an IC50 of 0.24 μM.</p>
    Formula:C15H16FN5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:285.32

    Ref: TM-T79630

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    EGFR/CDK2-IN-2

    <p>EGFR/CDK2-IN-2 (compound 6a) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 19.6 nM and 87.9 nM, respectively.</p>
    Formula:C49H32N12O2S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:884.99

    Ref: TM-T79727

  • Cdk2/Cyclin Inhibitory Peptide I
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    Cdk2/Cyclin Inhibitory Peptide I

    <p>CDK2, a Ser/Thr kinase, is akin to yeast cdc28 and human Cdk1, crucial for cell division.</p>
    Formula:C111H196N48O23
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2571.05

    Ref: TM-TP2192

  • CDK7-IN-7
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    CDK7-IN-7

    CAS:
    <p>CDK7-IN-7: Selective CDK7 inhibitor, IC50 &lt; 50 nM (Patent CN112661745A).</p>
    Formula:C20H20BrF3N6O2
    Color and Shape:Solid
    Molecular weight:513.319

    Ref: TM-T40264

  • [pThr3]-CDK5 Substrate
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    [pThr3]-CDK5 Substrate

    CAS:
    <p>[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate.[pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM[1].</p>
    Formula:C53H100N15O15P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1218.43

    Ref: TM-TP1602

  • PROTAC CDK9 degrader-11
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    PROTAC CDK9 degrader-11

    CAS:
    <p>PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)</p>
    Formula:C39H48Cl2N10O5
    Color and Shape:Solid
    Molecular weight:807.768

    Ref: TM-T205652

  • IV-361
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    IV-361

    CAS:
    <p>IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1</p>
    Formula:C23H32FN5O2Si
    Color and Shape:Solid
    Molecular weight:457.625

    Ref: TM-T39456

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    EGFR/CDK2-IN-3

    <p>EGFR/CDK2-IN-3 (compound 4b) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 71.7 nM and 113.7 nM, respectively.</p>
    Formula:C30H20N6OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:512.58

    Ref: TM-T79728

  • CDK5-IN-1
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    CDK5-IN-1

    CAS:
    <p>CDK5-IN-1: Potent CDK5 inhibitor (&lt;10 nM) used in kidney disease research.</p>
    Formula:C24H25FN6O3S
    Color and Shape:Solid
    Molecular weight:496.56

    Ref: TM-T40263

  • YKL-5-124 TFA
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    YKL-5-124 TFA

    CAS:
    <p>YKL-5-124 TFA is a potent CDK7 inhibitor (IC50: 53.5 nM), more than 100x selective over CDK9/2, not active on CDK12/13, and disrupts the cell cycle.</p>
    Formula:C30H34F3N7O5
    Color and Shape:Solid
    Molecular weight:629.63

    Ref: TM-T73633

  • Cell Cycle Compound Library
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    Cell Cycle Compound Library

    <p>A unique collection of xnum cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS);</p>
    Color and Shape:Odour Solid

    Ref: TM-L8100

  • CDK2-IN-43
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    CDK2-IN-43

    <p>CDK2-IN-43 (Compound 3a) is a CDK2-cyclin E2 inhibitor with an IC50 value of 6.0 nM. It is applicable to cancer research.</p>
    Formula:C19H27N7O
    Color and Shape:Solid
    Molecular weight:369.464

    Ref: TM-T206067

  • CDK1-IN-2
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    CDK1-IN-2

    CAS:
    <p>CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM.</p>
    Formula:C17H11ClN2O
    Purity:98.53%
    Color and Shape:Soild
    Molecular weight:294.73

    Ref: TM-T64373