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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 525 products of "CDK"

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  • Milciclib
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    Milciclib

    CAS:
    Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.
    Formula:C25H32N8O
    Purity:99.28%
    Color and Shape:Solid
    Molecular weight:460.57

    Ref: TM-T6081

  • SEL120-34A HCl
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    SEL120-34A HCl

    CAS:
    SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectively
    Formula:C15H19Br2ClN4
    Purity:98.13% - 98.47%
    Color and Shape:Solid
    Molecular weight:450.6

    Ref: TM-T10744L

  • SNS-032
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    SNS-032

    CAS:
    SNS-032 (BMS-387032) is a selective inhibitor of CDK2 and is 10- and 20-fold selective over CDK1/CDK4. SNS-032 is sensitive to CDK7/9, and no effect on CDK6.
    Formula:C17H24N4O2S2
    Purity:98.27% - 99.91%
    Color and Shape:Solid
    Molecular weight:380.53

    Ref: TM-T6049

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    Dalpiciclib hydrochloride

    Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.
    Formula:C25H31ClN6O2
    Color and Shape:Solid
    Molecular weight:483.01

    Ref: TM-T63199

  • AZD-5597
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    AZD-5597

    CAS:
    <p>AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potent</p>
    Formula:C23H28FN7O
    Purity:98.01%
    Color and Shape:Solid
    Molecular weight:437.51

    Ref: TM-T21544

  • AS2863619
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    AS2863619

    CAS:
    AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.
    Formula:C16H14Cl2N8O
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:405.24

    Ref: TM-T8378

  • PHA-767491
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    PHA-767491

    CAS:
    PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.
    Formula:C12H11N3O
    Purity:99.49% - >99.99%
    Color and Shape:Solid
    Molecular weight:213.24

    Ref: TM-T6206

  • 6-(Dimethylamino)purine
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    6-(Dimethylamino)purine

    CAS:
    6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitor
    Formula:C7H9N5
    Purity:99.01% - 99.77%
    Color and Shape:Solid
    Molecular weight:163.18

    Ref: TM-T7444

  • NVP-LCQ195
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    NVP-LCQ195

    CAS:
    NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).
    Formula:C17H19Cl2N5O4S
    Purity:99.56% - 99.85%
    Color and Shape:Solid
    Molecular weight:460.33

    Ref: TM-TQ0068

  • ON-013100
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    ON-013100

    CAS:
    ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.
    Formula:C19H22O7S
    Purity:98.27%
    Color and Shape:Solid
    Molecular weight:394.44

    Ref: TM-T16391

  • LDC000067
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    LDC000067

    CAS:
    LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.
    Formula:C18H18N4O3S
    Purity:98.08% - 99.07%
    Color and Shape:Solid
    Molecular weight:370.43

    Ref: TM-T6563

  • AT7519 TFA
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    AT7519 TFA

    CAS:
    AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.
    Formula:C18H18Cl2F3N5O4
    Color and Shape:Solid
    Molecular weight:496.27

    Ref: TM-T22590

  • Senexin B
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    Senexin B

    CAS:
    Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).
    Formula:C27H26N6O
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:450.53

    Ref: TM-T8430

  • HQ461
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    HQ461

    CAS:
    HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.
    Formula:C15H15N5OS2
    Purity:98.11%
    Color and Shape:Solid
    Molecular weight:345.44

    Ref: TM-T9849

  • LY3143921
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    LY3143921

    CAS:
    LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].
    Formula:C16H12FN5O
    Color and Shape:Solid
    Molecular weight:309.3

    Ref: TM-T60747

  • THAL-SNS-032
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    THAL-SNS-032

    CAS:
    THAL-SNS-032 is a selective CDK9 degrader PROTAC.
    Formula:C40H52N8O10S2
    Purity:99.68%
    Color and Shape:Solid
    Molecular weight:869.02

    Ref: TM-T17069

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    Palbociclib dihydrochloride

    <p>Palbociclib, oral CDK4/6 inhibitor (IC50: 11/16 nM), targets HR+/HER2- breast cancer and hepatocellular carcinoma.</p>
    Formula:C24H31Cl2N7O2
    Color and Shape:Solid
    Molecular weight:520.45

    Ref: TM-T63634

  • M2N12
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    M2N12

    CAS:
    M2N12 selectively inhibits Cdc25C (IC50=0.09μM) and has anti-tumor properties, affecting Cdc25A and B as well.
    Formula:C20H16ClN5O2
    Purity:98.01%
    Color and Shape:Solid
    Molecular weight:393.83

    Ref: TM-T11929

  • AG-494
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    AG-494

    CAS:
    AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.
    Formula:C16H12N2O3
    Purity:98.69%
    Color and Shape:Solid
    Molecular weight:280.28

    Ref: TM-T4205

  • SCH900776
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    SCH900776

    CAS:
    SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.
    Formula:C15H18BrN7
    Purity:96.69% - 99.6%
    Color and Shape:Solid
    Molecular weight:376.25

    Ref: TM-T2517