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CDK

CDK

CDK (Cyclin-Dependent Kinase) inhibitors are compounds that block the activity of CDKs, a group of protein kinases that regulate the cell cycle, transcription, and other cellular processes. CDKs are activated by binding to cyclins, and their activity is crucial for the progression of cells through different phases of the cell cycle. Inhibiting CDKs can halt cell division, leading to cell cycle arrest and apoptosis, particularly in cancer cells where CDKs are often dysregulated. CDK inhibitors are widely used in cancer research and have therapeutic potential in treating various cancers. At CymitQuimica, we provide a comprehensive selection of high-quality CDK inhibitors to support your research in cell cycle control, cancer, and therapeutic development.

Found 526 products of "CDK"

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  • CCT-251921
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    CCT-251921

    CAS:
    CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).
    Formula:C21H23ClN6O
    Purity:99.07%
    Color and Shape:Solid
    Molecular weight:410.9

    Ref: TM-T14901

  • KM05382
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    KM05382

    CAS:
    KM05382 inhibits CDK9 and the transcription of GAPDH.
    Formula:C20H19ClN2O3S2
    Color and Shape:Solid
    Molecular weight:434.96

    Ref: TM-T27735

  • DCB-3503
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    DCB-3503

    CAS:
    DCB-3503, a tylophorine analog, may fight cancer and aid immunosuppression by hindering protein synthesis and modulating HSC70 ATPase function.
    Formula:C24H27NO5
    Color and Shape:Solid
    Molecular weight:409.47

    Ref: TM-T27128

  • CDK9-IN-9
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    CDK9-IN-9

    CAS:
    <p>CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).</p>
    Formula:C22H23F2N5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:459.51

    Ref: TM-T10747

  • CDK9-IN-2
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    CDK9-IN-2

    CAS:
    CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.
    Formula:C23H25ClFN5
    Purity:99%
    Color and Shape:Solid
    Molecular weight:425.93

    Ref: TM-T14918

  • PF-6808472
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    PF-6808472

    CAS:
    PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.
    Formula:C25H27FN8O3S
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:538.6

    Ref: TM-T33955

  • CDK7-IN-22
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    CDK7-IN-22

    CAS:
    CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].
    Formula:C22H25F3N6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:430.47

    Ref: TM-T79169

  • Bisindolylmaleimide X hydrochloride
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    Bisindolylmaleimide X hydrochloride

    CAS:
    Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).
    Formula:C26H25ClN4O2
    Purity:99.23%
    Color and Shape:Solid
    Molecular weight:460.96

    Ref: TM-T10550

  • Cdc7-IN-7
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    Cdc7-IN-7

    CAS:
    <p>Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.</p>
    Formula:C21H22N4O5
    Purity:98.78%
    Color and Shape:Solid
    Molecular weight:410.42

    Ref: TM-T10729

  • Mevociclib
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    Mevociclib

    CAS:
    Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.
    Formula:C31H35ClN8O2
    Purity:98.02% - 98.02%
    Color and Shape:Solid
    Molecular weight:587.11

    Ref: TM-T13044

  • 5-Iodo-indirubin-3'-monoxime
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    5-Iodo-indirubin-3'-monoxime

    CAS:
    5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s
    Formula:C16H10IN3O2
    Color and Shape:Solid
    Molecular weight:403.17

    Ref: TM-T10172

  • Voruciclib hydrochloride
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    Voruciclib hydrochloride

    CAS:
    Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
    Formula:C22H20Cl2F3NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:506.3

    Ref: TM-T13309

  • Senexin C
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    Senexin C

    CAS:
    Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.
    Formula:C28H27N5O
    Purity:98.06%
    Color and Shape:Solid
    Molecular weight:449.55

    Ref: TM-T62702

  • CDK9-IN-23
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    CDK9-IN-23

    CAS:
    CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].
    Formula:C22H25ClN4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:428.91

    Ref: TM-T79037

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    CDK7-IN-25

    CAS:
    CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].
    Formula:C33H32N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:560.65

    Ref: TM-T79881

  • CDK4/6-IN-17
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    CDK4/6-IN-17

    CAS:
    CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.
    Formula:C27H28F4N8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:540.56

    Ref: TM-T79112

  • CDK9-IN-29
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    CDK9-IN-29

    CAS:
    <p>CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.</p>
    Formula:C29H33F2N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:553.6

    Ref: TM-T82757

  • QR-6401
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    QR-6401

    CAS:
    <p>QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/</p>
    Formula:C19H23N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:369.42

    Ref: TM-T79014

  • Tacaciclib
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    Tacaciclib

    CAS:
    Tacaciclib is a cyclin-dependent kinase (CDK) inhibitor with observed antineoplastic activity [1].
    Formula:C30H36N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:528.65

    Ref: TM-T79862

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    Palbociclib orotate

    CAS:
    <p>Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.</p>
    Formula:C29H33N9O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:603.63

    Ref: TM-T72507