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Microtubule Associated

Microtubule Associated

Microtubule-associated protein inhibitors target proteins that interact with microtubules, the structural components of the cell's cytoskeleton that are essential for cell division. These proteins regulate the stability and dynamics of microtubules during mitosis. Inhibiting microtubule-associated proteins can disrupt microtubule function, leading to cell cycle arrest and apoptosis, particularly in rapidly dividing cancer cells. These inhibitors are widely used in cancer research and drug development. At CymitQuimica, we offer a comprehensive range of high-quality microtubule-associated protein inhibitors to support your research in cell division, cytoskeletal dynamics, and cancer therapy.

Found 261 products of "Microtubule Associated"

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  • DM1-SMe
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    DM1-SMe

    CAS:
    <p>DM1-SMe (DM1-SSMe) potently inhibits microtubules, 3-10x stronger than Maytansine with IC50s of 0.003-0.01 nM in human cancer cells.</p>
    Formula:C36H50ClN3O10S2
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:784.38

    Ref: TM-T21408

  • LY3372689
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    LY3372689

    CAS:
    <p>LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor for tau protein-based disorders including Alzheimer's disease.</p>
    Formula:C16H22FN5O3S
    Purity:99.43% - 99.53%
    Color and Shape:Solid
    Molecular weight:383.44

    Ref: TM-T61661

  • SB-216
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    SB-216

    CAS:
    <p>SB-216, a potent anti-cancer compound, inhibits tubulin polymerization and curbs growth in various cancer cells.</p>
    Formula:C17H18N4O2
    Purity:99.70%
    Color and Shape:Solid
    Molecular weight:310.35

    Ref: TM-T60757

  • Rosabulin
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    Rosabulin

    CAS:
    <p>v Rosabulin (STA 5312) is an orally active microtubule inhibitor with potency.</p>
    Formula:C22H16N4O2S
    Purity:98.06%
    Color and Shape:Solid
    Molecular weight:400.45

    Ref: TM-T16788

  • JH-VIII-157-02
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    JH-VIII-157-02

    CAS:
    <p>JH-VIII-157-02 inhibits ALK, specifically EML4-ALK variants, with IC50s of 2 nM.</p>
    Formula:C28H27N5O2
    Purity:99.58%
    Color and Shape:Solid
    Molecular weight:465.55

    Ref: TM-T15612

  • CID-663143
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    CID-663143

    CAS:
    <p>CID-663143 inhibits cancer cell growth and shows microtubule-binding activity.</p>
    Formula:C19H18N4O2S
    Purity:99.68% - 99.77%
    Color and Shape:Solid
    Molecular weight:366.44

    Ref: TM-T23889

  • Erbulozole
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    Erbulozole

    CAS:
    <p>Erbulozole (R 55104) is a synthetic microtubule inhibitor with anti-invasive activity that induces Wernicke's encephalopathy-like neurotoxicity.</p>
    Formula:C24H27N3O5S
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:469.55

    Ref: TM-T25384

  • KIF18A-IN-7
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    KIF18A-IN-7

    CAS:
    <p>KIF18A-IN-7 is an orally active inhibitor targeting KIF18A, demonstrating potent inhibition with an IC50 value of 9.4 nM against the microtubule-dependent</p>
    Formula:C27H35N3O5S2
    Color and Shape:Soild
    Molecular weight:545.71

    Ref: TM-T73050

  • Oxaline
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    Oxaline

    CAS:
    <p>Oxaline, a fungal alkaloid derived from Penicillium oxalicum, impedes tubulin polymerization, leading to cell cycle arrest at the M phase [1] [2].</p>
    Formula:C24H25N5O4
    Color and Shape:Solid
    Molecular weight:447.49

    Ref: TM-T85040

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    Dolastatinol

    CAS:
    <p>Dolastatinol, a synthetic analog of Dolastatin 10, serves as a potent low-nanomolar inhibitor of tubulin polymerization.</p>
    Formula:C43H70N6O7S
    Color and Shape:Solid
    Molecular weight:815.12

    Ref: TM-T74148

  • Valecobulin hydrochloride
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    Valecobulin hydrochloride

    CAS:
    <p>Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516.Cost-effective and quality-assured.</p>
    Formula:C26H29ClN6O5S
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:573.06

    Ref: TM-T13278

  • JG-23
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    JG-23

    CAS:
    <p>JG-23, a 4-chloro-modified analog, effectively induces t-tau degradation and demonstrates robust metabolic stability, exhibiting an extended half-life (T1/2) of</p>
    Formula:C19H16ClN3OS2
    Color and Shape:Solid
    Molecular weight:401.93

    Ref: TM-T78533

  • Tubulin polymerization-IN-52
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    Tubulin polymerization-IN-52

    CAS:
    <p>Tubulin polymerization-IN-52 (compound SC23) effectively inhibits tubulin polymerization, exhibiting an IC50 value of 2.9 μM [1].</p>
    Formula:C21H18F3N5O3
    Color and Shape:Solid
    Molecular weight:445.39

    Ref: TM-T79766

  • CNS-11
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    CNS-11

    CAS:
    <p>CNS-11, a compound that disaggregates tau fibrils, is utilized in Alzheimer's disease (AD) research [1].</p>
    Formula:C25H21N3O2
    Color and Shape:Solid
    Molecular weight:395.45

    Ref: TM-T84812

  • MK-6240
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    MK-6240

    CAS:
    <p>MK-6240: A tau PET tracer with high specificity for NFTs binding.</p>
    Formula:C16H11FN4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:278.28

    Ref: TM-T19429

  • Tubulin inhibitor 25
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    Tubulin inhibitor 25

    CAS:
    <p>Potent Tubulin inhibitor 25: IC50 0.98 μM, blocks HT29 cell growth, hinders cell migration &amp; microtubule formation, anti-angiogenic.</p>
    Formula:C26H22O8
    Color and Shape:Solid
    Molecular weight:462.45

    Ref: TM-T62922

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    Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2

    CAS:
    <p>Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 demonstrates serum stability and non-toxicity to neuronal cells, while selectively inhibiting the fibrilization of tau in</p>
    Formula:C38H65N11O9
    Color and Shape:Solid
    Molecular weight:819.99

    Ref: TM-T76217

  • PBB3
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    PBB3

    CAS:
    <p>PBB3 is a tau-specific PET tracer.</p>
    Formula:C17H15N3OS
    Color and Shape:Solid
    Molecular weight:309.39

    Ref: TM-T33890

  • THK-5105
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    THK-5105

    CAS:
    <p>THK-5105, a tau-binding arylquinoline, could be an 18F-PET imaging probe for Alzheimer's disease.</p>
    Formula:C20H21FN2O2
    Color and Shape:Solid
    Molecular weight:340.39

    Ref: TM-T61087

  • 3,4',5-Trismethoxybenzophenone
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    3,4',5-Trismethoxybenzophenone

    CAS:
    <p>3,4',5-Trismethoxybenzophenone (compound 16a) is an effective inhibitor of tubulin assembly, demonstrating a half-maximal inhibitory concentration (IC 50) of 2.6 µM [1].</p>
    Formula:C16H16O4
    Color and Shape:Solid
    Molecular weight:272.3

    Ref: TM-T84553