Microtubule Associated
Microtubule-associated protein inhibitors target proteins that interact with microtubules, the structural components of the cell's cytoskeleton that are essential for cell division. These proteins regulate the stability and dynamics of microtubules during mitosis. Inhibiting microtubule-associated proteins can disrupt microtubule function, leading to cell cycle arrest and apoptosis, particularly in rapidly dividing cancer cells. These inhibitors are widely used in cancer research and drug development. At CymitQuimica, we offer a comprehensive range of high-quality microtubule-associated protein inhibitors to support your research in cell division, cytoskeletal dynamics, and cancer therapy.
Found 283 products of "Microtubule Associated"
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Alyssin
CAS:Alyssin: sulforaphane analog, antioxidant; boosts Nrf2 and phase II enzymes in cancer cells; lowers PAH metabolism, reducing cancer risk in vitro.Formula:C7H13NOS2Purity:98%Color and Shape:SolidMolecular weight:191.31Tubulin polymerization-IN-42
CAS:Tubulin polymerization-IN-42 (compound 10j), an indole-substituted furanone, inhibits tubulin polymerization and exhibits anti-cancer properties [1].Formula:C22H21NO5Color and Shape:SolidMolecular weight:379.41Cevipabulin
CAS:Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cellFormula:C18H18ClF5N6OPurity:99.53%Color and Shape:SolidMolecular weight:464.82IQTub4P
CAS:IQTub4P is a potent inhibitor of microtubules. IQTub4P exhibits cytotoxicity in HeLa cells (EC50: 170 nM).Formula:C19H18NNa2O8PColor and Shape:SolidMolecular weight:465.305Tau protein aggregation-IN-1
CAS:Tau Protein Aggregation-IN-1 (Compound 0c) serves as an inhibitor of Tau protein aggregation, applicable in research related to protein folding disordersFormula:C17H11BrN2O2Color and Shape:SolidMolecular weight:355.19Tau-aggregation and neuroinflammation-IN-1
CAS:Potent tau aggregate inhibitor, anti-inflammatory, low cytotoxicity, reverses memory impairment in rats.Formula:C25H20N2O7Purity:99.85%Color and Shape:SolidMolecular weight:460.44Sabeluzole
CAS:Sabeluzole (R-58735) has antiepileptic and cognitive enhancing properties and may be used in the study of Alzheimer's disease.Formula:C22H26FN3O2SPurity:98.51%Color and Shape:SolidMolecular weight:415.52Microtubule inhibitor 6
CAS:Compound 17o inhibits microtubules, toxic to NCI-H460, BxPC-3, HT-29 cells (IC50: 14.0, 6.6, 7.0 nM), blocks polymerization.Formula:C24H19FN2O5Color and Shape:SolidMolecular weight:434.42Tubulin inhibitor 29
CAS:Compound 3c, a tubulin inhibitor, blocks assembly at colchicine site with IC50 of 1.2 μM; anti-proliferative IC50 7.5 μM in MCF-7 cells.Formula:C12H8F2O2S2Color and Shape:SolidMolecular weight:286.32Tubulin inhibitor 31
Tubulin inhibitor 31: potent with 4 µM IC50, anti-proliferative, inhibits HUVEC migration.Formula:C22H19NO2Color and Shape:SolidMolecular weight:329.39Tubulin polymerization-IN-7
CAS:Tubulin aggregation-IN-7 is a potent tubulin aggregation inhibitor that has shown research potential for cancer diseases.Formula:C28H24N4O6SColor and Shape:SolidMolecular weight:544.58Tubulin polymerization-IN-30
CAS:Compound 6e inhibits tubulin polymerization, disrupts microtubules, halts G2/M phase, and targets HeLa, SGC-7901, A549 with low IC50.Formula:C22H25N5O3Color and Shape:SolidMolecular weight:407.47Anticancer agent 60
CAS:Anticancer agent 60 hinders HepG2 cell growth with IC50 of 4.13 μM and suppresses tumors in HepG2 mouse model.Formula:C27H33N5O4SColor and Shape:SolidMolecular weight:523.65AMXI-5001
CAS:AMXI-5001: potent oral parp1/2 inhibitor, blocks microtubules, strong anti-cancer effects, lower IC50s, and can shrink large tumors.Formula:C25H20FN5O3Color and Shape:SolidMolecular weight:457.46LY3372689
CAS:<p>LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor for tau protein-based disorders including Alzheimer's disease.</p>Formula:C16H22FN5O3SPurity:99.43% - 99.53%Color and Shape:SolidMolecular weight:383.44Tubulin inhibitor 8
CAS:<p>Tubulin inhibitor 8 blocks tubulin polymerization, stunts K562 cancer cell growth; IC50: 0.73 μM, 14 nM.</p>Formula:C21H14N2O3Purity:98.51% - 99.87%Color and Shape:SolidMolecular weight:342.35JH-VIII-157-02
CAS:JH-VIII-157-02 inhibits ALK, specifically EML4-ALK variants, with IC50s of 2 nM.Formula:C28H27N5O2Purity:99.58%Color and Shape:SolidMolecular weight:465.55Ref: TM-T15612
1mg116.00€5mg240.00€10mg358.00€25mg558.00€50mg753.00€100mg1,035.00€1mL*10mM (DMSO)246.00€Erbulozole
CAS:Erbulozole (R 55104) is a synthetic microtubule inhibitor with anti-invasive activity that induces Wernicke's encephalopathy-like neurotoxicity.Formula:C24H27N3O5SPurity:99.88%Color and Shape:SolidMolecular weight:469.55SB-216
CAS:<p>SB-216, a potent anti-cancer compound, inhibits tubulin polymerization and curbs growth in various cancer cells.</p>Formula:C17H18N4O2Purity:99.70%Color and Shape:SolidMolecular weight:310.35Rosabulin
CAS:<p>v Rosabulin (STA 5312) is an orally active microtubule inhibitor with potency.</p>Formula:C22H16N4O2SPurity:98.06%Color and Shape:SolidMolecular weight:400.45CID-663143
CAS:CID-663143 inhibits cancer cell growth and shows microtubule-binding activity.Formula:C19H18N4O2SPurity:99.68% - 99.77%Color and Shape:SolidMolecular weight:366.44Ref: TM-T23889
1mg52.00€5mg111.00€10mg163.00€25mg235.00€50mg333.00€100mg447.00€200mg592.00€1mL*10mM (DMSO)115.00€TCS 2210
CAS:TCS 2210 promotes neuronal differentiation in stem cells, boosting β-III tubulin and enolase markers.Formula:C18H17N3O3Purity:98.62%Color and Shape:SolidMolecular weight:323.35Ref: TM-T23446
1mg90.00€2mg123.00€5mg182.00€10mg274.00€25mg469.00€50mg643.00€100mg914.00€500mg1,833.00€1mL*10mM (DMSO)187.00€DM1-SMe
CAS:<p>DM1-SMe (DM1-SSMe) potently inhibits microtubules, 3-10x stronger than Maytansine with IC50s of 0.003-0.01 nM in human cancer cells.</p>Formula:C36H50ClN3O10S2Purity:99.61%Color and Shape:SolidMolecular weight:784.38Oxaline
CAS:Oxaline, a fungal alkaloid derived from Penicillium oxalicum, impedes tubulin polymerization, leading to cell cycle arrest at the M phase [1] [2].Formula:C24H25N5O4Color and Shape:SolidMolecular weight:447.49Valecobulin hydrochloride
CAS:Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516.Cost-effective and quality-assured.Formula:C26H29ClN6O5SPurity:99.52%Color and Shape:SolidMolecular weight:573.06Ref: TM-T13278
1mg88.00€5mg170.00€10mg259.00€25mg429.00€50mg605.00€100mg815.00€200mg1,093.00€1mL*10mM (DMSO)207.00€N-Deacetylcolchicine
CAS:Trimethylcolchicinic acid methyl ether (HAN 76504), an antimitotic agent, blocks microtubule assembly by attaching to tubulin and inhibiting its polymerization. It enhances tubulin's intrinsic GTPase activity, induces apoptosis across various normal and tumor cell lines, and activates the JNK/SAPK pathway. Currently unnamed, it is referred to by a provisional code name in line with MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming) for ease of communication.Formula:C20H23NO5Color and Shape:SolidMolecular weight:357.4Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2
CAS:Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 demonstrates serum stability and non-toxicity to neuronal cells, while selectively inhibiting the fibrilization of tau inFormula:C38H65N11O9Color and Shape:SolidMolecular weight:819.99Anticancer agent 40
CAS:Anticancer agent 3e targets SKBR-3, SKOV-3, PC-3, U-87 (IC50 ~0.95 nM) and HDF cells (IC50: 2.13 nM).Formula:C25H29NO6Color and Shape:SolidMolecular weight:439.5THK-5105
CAS:THK-5105, a tau-binding arylquinoline, could be an 18F-PET imaging probe for Alzheimer's disease.Formula:C20H21FN2O2Color and Shape:SolidMolecular weight:340.39Tubulin polymerization-IN-52
CAS:Tubulin polymerization-IN-52 (compound SC23) effectively inhibits tubulin polymerization, exhibiting an IC50 value of 2.9 μM [1].Formula:C21H18F3N5O3Color and Shape:SolidMolecular weight:445.39JG-23
CAS:JG-23, a 4-chloro-modified analog, effectively induces t-tau degradation and demonstrates robust metabolic stability, exhibiting an extended half-life (T1/2) ofFormula:C19H16ClN3OS2Color and Shape:SolidMolecular weight:401.93ASN90
CAS:ASN90 is a specific, orally active inhibitor of the O-GlcNAcase (OGA) enzyme, demonstrating an IC50 of 10.2 nM.Formula:C17H21N5O3SColor and Shape:SolidMolecular weight:375.45MK-6240
CAS:MK-6240: A tau PET tracer with high specificity for NFTs binding.Formula:C16H11FN4Purity:98%Color and Shape:SolidMolecular weight:278.28Antitumor agent-67
CAS:Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells.Formula:C45H47NO13Color and Shape:SolidMolecular weight:809.85CNS-11
CAS:CNS-11, a compound that disaggregates tau fibrils, is utilized in Alzheimer's disease (AD) research [1].Formula:C25H21N3O2Color and Shape:SolidMolecular weight:395.453,4',5-Trismethoxybenzophenone
CAS:3,4',5-Trismethoxybenzophenone (compound 16a) is an effective inhibitor of tubulin assembly, demonstrating a half-maximal inhibitory concentration (IC 50) of 2.6 µM [1].Formula:C16H16O4Color and Shape:SolidMolecular weight:272.3Dolastatinol
CAS:Dolastatinol, a synthetic analog of Dolastatin 10, serves as a potent low-nanomolar inhibitor of tubulin polymerization.Formula:C43H70N6O7SColor and Shape:SolidMolecular weight:815.12PBB3
CAS:PBB3 is a tau-specific PET tracer.Formula:C17H15N3OSColor and Shape:SolidMolecular weight:309.39Tubulin inhibitor 25
CAS:Potent Tubulin inhibitor 25: IC50 0.98 μM, blocks HT29 cell growth, hinders cell migration & microtubule formation, anti-angiogenic.Formula:C26H22O8Color and Shape:SolidMolecular weight:462.45Tasidotin hydrochloride
CAS:Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.Formula:C32H59ClN6O5Purity:98%Color and Shape:SolidMolecular weight:643.30Monomethyl auristatin E intermediate-17
CAS:MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).Formula:C27H35NO7SMolecular weight:517.63PROTAC α-synuclein degrader 6
CAS:<p>PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.</p>Formula:C37H39N5O9SMolecular weight:729.80PM-060184
CAS:PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.Formula:C31H45N3O7Purity:98%Color and Shape:SolidMolecular weight:571.7Tubulin polymerization-IN-32
Tubulin polymerization-IN-32: a cancer cell growth inhibitor used for research in cancers like lymphoma.Formula:C29H30N2O7Color and Shape:SolidMolecular weight:518.56Tubulin polymerization-IN-8
CAS:Compound IIc inhibits tubulin polymerization, arrests cell cycle at G2/M in HCT116 cells, IC50 12.7 μM, potential for cancer research.Formula:C21H24N4O4SColor and Shape:SolidMolecular weight:428.5Utrophin modulator 1
UM1 upregulates utrophin, has EC50 of 0.11 μM, useful in DMD research.Formula:C22H18N6OColor and Shape:SolidMolecular weight:382.42Antitubulin agent 1
Antitubulin agents-1 disrupts microtubules, ups α-tubulin acetylation, and has anticancer properties.Formula:C21H19N3O3Color and Shape:SolidMolecular weight:361.39OXS007417
OXS007417 induces AML cell differentiation at 48 nM EC50 and shows potent in vivo antitumor effects.Formula:C20H14F3N3OColor and Shape:SolidMolecular weight:369.34Epothilone E
CAS:Epothilone E, a derivative of epothilone, functions by inhibiting microtubule protein activity, thereby halting cell division and exhibiting anti-tumorFormula:C26H39NO7SColor and Shape:SolidMolecular weight:509.66JC168
CAS:JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.Formula:C26H40O7Color and Shape:SolidMolecular weight:464.592AMXI-5001 hydrochloride
AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.Formula:C25H21ClFN5O3Color and Shape:SolidMolecular weight:493.92Tubulin polymerization-IN-35
Tubulin-IN-35 inhibits oxazolylisoindole microtubule formation, targeting VL51 marginal zone lymphoma.Formula:C31H35N3O5Color and Shape:SolidMolecular weight:529.63Tau ligand-1
CAS:Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.Formula:C17H16FN3OColor and Shape:SolidMolecular weight:297.327TTBK1/2-IN-1
CAS:TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.Formula:C17H16N4OColor and Shape:SolidMolecular weight:292.335Icafolin-methyl
CAS:Icafolin-methyl is a plant-specific herbicide that acts as an inhibitor of tubulin polymerization. In plants, it metabolizes into the carboxylic acid icafolin, potentially inhibiting plant tubulin polymerization by binding to β-tubulin.Formula:C18H18F2N2O5Color and Shape:SolidMolecular weight:380.343Tubulin polymerization-IN-75
CAS:Tubulin polymerization-IN-75 (Compound 6) is an inhibitor of tubulin polymerization, with an IC50 value of 30 μM. It effectively suppresses the proliferation of cancer cells Huh7 and 293T, demonstrating IC50 values of 14.3 μM and 13.8 μM, respectively.Formula:C14H11NOColor and Shape:SolidMolecular weight:209.243Tubulin inhibitor 15
Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 15 exhibits cytotoxicity in HepG2 cells [1].Formula:C16H12FNO2Color and Shape:SolidMolecular weight:269.27Dictyostatin
CAS:Dictyostatin: potent microtubule stabilizer & anticancer agent with antiproliferative effects; researched for tauopathies.Formula:C32H52O6Color and Shape:SolidMolecular weight:532.75AMG28
CAS:AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.Formula:C20H20N4OColor and Shape:SolidMolecular weight:332.399Tubulin inhibitor 19
Tubulin inhibitor 19 (9b), a potent indole chalcone, strongly blocks tubulin, valuable in cancer studies.Formula:C21H23NO5Color and Shape:SolidMolecular weight:369.41TPI-287
CAS:TPI 287: synthetic taxane; may halt cancer by stabilizing microtubules, blocking cell division, inducing apoptosis.Formula:C46H63NO15Color and Shape:SolidMolecular weight:869.99Sagopilone
CAS:Sagopilone: synthetic epothilone, inhibits cell division and induces apoptosis, effective in MDR tumors, not P-gp substrate.Formula:C30H41NO6SColor and Shape:SolidMolecular weight:543.71Antitumor agent-200
CAS:Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.Formula:C19H21FN2O3SeColor and Shape:SolidMolecular weight:423.34Myoseverin B
CAS:Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.Formula:C27H32N6O2Color and Shape:SolidMolecular weight:472.582Tubulin inhibitor 16
Tubulin inhibitor 16 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 16 exhibits cytotoxicity in HepG2 cells [1].Formula:C16H12FNO2Color and Shape:SolidMolecular weight:269.27Alfalone
CAS:Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.Formula:C17H14O5Color and Shape:SolidMolecular weight:298.29Tubulin polymerization-IN-63
CAS:Tubulin polymerization-IN-63 (compound 6) is an inhibitor of tubulin polymerization. It exhibits an IC50 value of 0.29 μM against MES-SA cells, making it suitable for use in cancer research.Formula:C20H24ClCuN5O2SColor and Shape:SolidMolecular weight:497.5Tubulin polymerization-IN-77
CAS:Tubulin polymerization-IN-77 (Compound 15c) is a microtubule polymerization inhibitor that exhibits anti-glioblastoma activity by hindering microtubule polymerization. It demonstrates significant blood-brain barrier permeability, effectively induces G2/M phase arrest in GBM cells, and triggers apoptosis, while also markedly inhibiting tumor cell migration.Formula:C22H19BrF3NO7Color and Shape:SolidMolecular weight:546.288Tubulin inhibitor 22
Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.Formula:C20H17BrFNO4Color and Shape:SolidMolecular weight:434.26TACC3 inhibitor 2
CAS:TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.Formula:C20H22FN5O2Color and Shape:SolidMolecular weight:383.419Auristatin S
CAS:AuristatinS is a potent anti-tumor agent that serves as an Auristatin payload. It effectively reduces the bystander effect and decreases off-target toxicity. In the Karpas/KarpasBVR cell model, AuristatinS exhibits excellent tolerability. It can be used as the cytotoxic component in antibody-drug conjugates (ADCs) for treating various types of cancer.Formula:C38H65N5O8Color and Shape:SolidMolecular weight:719.95Lisavanbulin
CAS:<p>Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.</p>Formula:C26H29N9O3Color and Shape:SolidMolecular weight:515.57Tubulin polymerization-IN-34
"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."Formula:C31H35N3O6Color and Shape:SolidMolecular weight:545.63Tubulin polymerization-IN-74
CAS:Tubulin polymerization-IN-74 (compound 11) is an inhibitor of tubulin polymerization, with an IC50 value of 15 μM. It is applicable to cancer research.Formula:C14H11NSColor and Shape:SolidMolecular weight:225.309TTBK1/2-IN-3
CAS:TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).Formula:C21H22N4OColor and Shape:SolidMolecular weight:346.426Isodienestrol
CAS:Isodienestrol, a derivative of Diethylstilbestrol, acts as a microtubule (Microtubule) inhibitor. It is utilized in cancer research.Formula:C18H18O2Color and Shape:SolidMolecular weight:266.33Symplostatin 1
CAS:Symplostatin 1 is a dolastatin 10 analog from the marine cyanobacterium Symploca hydnoides.Formula:C43H70N6O6SColor and Shape:SolidMolecular weight:799.12Tubulin polymerization-IN-33
Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.Formula:C27H28N2O6Color and Shape:SolidMolecular weight:476.52Ombrabulin
CAS:Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.Formula:C21H26N2O6Purity:98%Color and Shape:SolidMolecular weight:402.44Tau tracer 2
CAS:Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].Formula:C15H9FN4Color and Shape:SolidMolecular weight:264.263Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate
CAS:Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T65302 and the CAS number is 20367-38-8.Formula:C9H8ClN3O2Color and Shape:SolidMolecular weight:225.63Cevipabulin fumarate
CAS:Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).Formula:C22H22ClF5N6O5Purity:98%Color and Shape:SolidMolecular weight:580.89
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