Microtubule Associated
Microtubule-associated protein inhibitors target proteins that interact with microtubules, the structural components of the cell's cytoskeleton that are essential for cell division. These proteins regulate the stability and dynamics of microtubules during mitosis. Inhibiting microtubule-associated proteins can disrupt microtubule function, leading to cell cycle arrest and apoptosis, particularly in rapidly dividing cancer cells. These inhibitors are widely used in cancer research and drug development. At CymitQuimica, we offer a comprehensive range of high-quality microtubule-associated protein inhibitors to support your research in cell division, cytoskeletal dynamics, and cancer therapy.
Found 274 products of "Microtubule Associated"
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Denibulin HCl
CAS:Denibulin (MN-029) disrupts tumor blood vessels by inhibiting microtubule assembly, enhancing radiation and cisplatin efficacy.Formula:C18H20ClN5O3SColor and Shape:SolidMolecular weight:421.9Centmitor-1
CAS:Centmitor-1 is a novel mitotic inducer that modulates the positive end of microtubules and reduces microtubule dynamics.Formula:C22H16BrN3O3Color and Shape:SolidMolecular weight:450.28CAY10701
CAS:CAY10701, a 7-deazahypoxanthine, impedes cell growth (GI50: 9-38 nM) while sparing normal fibroblasts (>1,500-fold), and shrinks mouse colorectal tumors.Formula:C24H19N3O2Color and Shape:SolidMolecular weight:381.43CHM-1-P-Na
CAS:CHM-1-P-Na is used as a hydrophilic prodrug of CHM-1.Formula:C16H11FNNaO6PColor and Shape:SolidMolecular weight:386.227Mivobulin
CAS:Mivobulin is an inhibitor of tubulin .Formula:C17H19N5O2Purity:98%Color and Shape:SolidMolecular weight:325.37Cevipabulin
CAS:Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cellFormula:C18H18ClF5N6OPurity:99.53%Color and Shape:SolidMolecular weight:464.82Tau-aggregation and neuroinflammation-IN-1
CAS:Potent tau aggregate inhibitor, anti-inflammatory, low cytotoxicity, reverses memory impairment in rats.Formula:C25H20N2O7Purity:99.85%Color and Shape:SolidMolecular weight:460.44CCB02
CAS:CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity.Formula:C14H9N3OPurity:98.38%Color and Shape:SolidMolecular weight:235.24Ref: TM-T10704
1mg73.00€5mg161.00€10mg245.00€25mg480.00€50mg735.00€100mg999.00€1mL*10mM (DMSO)172.00€S516
CAS:S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.Formula:C21H19N5O4SPurity:98%Color and Shape:SolidMolecular weight:437.47Tubulin inhibitor 8
CAS:Tubulin inhibitor 8 blocks tubulin polymerization, stunts K562 cancer cell growth; IC50: 0.73 μM, 14 nM.
Formula:C21H14N2O3Purity:98.51% - 99.87%Color and Shape:SolidMolecular weight:342.35TCS 2210
CAS:TCS 2210 promotes neuronal differentiation in stem cells, boosting β-III tubulin and enolase markers.Formula:C18H17N3O3Purity:98.62%Color and Shape:SolidMolecular weight:323.35Ref: TM-T23446
1mg86.00€2mg116.00€5mg172.00€10mg259.00€25mg444.00€50mg610.00€100mg867.00€500mg1,738.00€1mL*10mM (DMSO)177.00€LY3372689
CAS:LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor for tau protein-based disorders including Alzheimer's disease.
Formula:C16H22FN5O3SPurity:99.43% - 99.53%Color and Shape:SolidMolecular weight:383.44Rosabulin
CAS:v Rosabulin (STA 5312) is an orally active microtubule inhibitor with potency.Formula:C22H16N4O2SPurity:98.86%Color and Shape:SolidMolecular weight:400.45Ref: TM-T16788
1mg92.00€5mg230.00€10mg344.00€25mg623.00€50mg888.00€100mg1,341.00€1mL*10mM (DMSO)251.00€CID-663143
CAS:CID-663143 inhibits cancer cell growth and shows microtubule-binding activity.Formula:C19H18N4O2SPurity:99.68% - 99.77%Color and Shape:SolidMolecular weight:366.44Ref: TM-T23889
1mg50.00€5mg105.00€10mg155.00€25mg224.00€50mg315.00€100mg424.00€200mg560.00€1mL*10mM (DMSO)109.00€SB-216
CAS:SB-216, a potent anti-cancer compound, inhibits tubulin polymerization and curbs growth in various cancer cells.
Formula:C17H18N4O2Purity:99.70%Color and Shape:SolidMolecular weight:310.35Erbulozole
CAS:Erbulozole (R 55104) is a synthetic microtubule inhibitor with anti-invasive activity that induces Wernicke's encephalopathy-like neurotoxicity.Formula:C24H27N3O5SPurity:99.88%Color and Shape:SolidMolecular weight:469.55MK-6240
CAS:MK-6240: A tau PET tracer with high specificity for NFTs binding.Formula:C16H11FN4Purity:98%Color and Shape:SolidMolecular weight:278.28Oxaline
CAS:Oxaline, a fungal alkaloid derived from Penicillium oxalicum, impedes tubulin polymerization, leading to cell cycle arrest at the M phase [1] [2].Formula:C24H25N5O4Color and Shape:SolidMolecular weight:447.49ASN90
CAS:ASN90 is a specific, orally active inhibitor of the O-GlcNAcase (OGA) enzyme, demonstrating an IC50 of 10.2 nM.Formula:C17H21N5O3SColor and Shape:SolidMolecular weight:375.45THK-5105
CAS:THK-5105, a tau-binding arylquinoline, could be an 18F-PET imaging probe for Alzheimer's disease.Formula:C20H21FN2O2Color and Shape:SolidMolecular weight:340.39PBB3
CAS:PBB3 is a tau-specific PET tracer.Formula:C17H15N3OSColor and Shape:SolidMolecular weight:309.39CNS-11
CAS:CNS-11, a compound that disaggregates tau fibrils, is utilized in Alzheimer's disease (AD) research [1].Formula:C25H21N3O2Color and Shape:SolidMolecular weight:395.453,4',5-Trismethoxybenzophenone
CAS:3,4',5-Trismethoxybenzophenone (compound 16a) is an effective inhibitor of tubulin assembly, demonstrating a half-maximal inhibitory concentration (IC 50) of 2.6 µM [1].Formula:C16H16O4Color and Shape:SolidMolecular weight:272.3Dolastatinol
CAS:Dolastatinol, a synthetic analog of Dolastatin 10, serves as a potent low-nanomolar inhibitor of tubulin polymerization.Formula:C43H70N6O7SColor and Shape:SolidMolecular weight:815.12Anticancer agent 40
CAS:Anticancer agent 3e targets SKBR-3, SKOV-3, PC-3, U-87 (IC50 ~0.95 nM) and HDF cells (IC50: 2.13 nM).Formula:C25H29NO6Color and Shape:SolidMolecular weight:439.5Tubulin polymerization-IN-52
CAS:Tubulin polymerization-IN-52 (compound SC23) effectively inhibits tubulin polymerization, exhibiting an IC50 value of 2.9 μM [1].Formula:C21H18F3N5O3Color and Shape:SolidMolecular weight:445.39JG-23
CAS:JG-23, a 4-chloro-modified analog, effectively induces t-tau degradation and demonstrates robust metabolic stability, exhibiting an extended half-life (T1/2) ofFormula:C19H16ClN3OS2Color and Shape:SolidMolecular weight:401.93N-Deacetylcolchicine
CAS:Trimethylcolchicinic acid methyl ether (HAN 76504), an antimitotic agent, blocks microtubule assembly by attaching to tubulin and inhibiting its polymerization. It enhances tubulin's intrinsic GTPase activity, induces apoptosis across various normal and tumor cell lines, and activates the JNK/SAPK pathway. Currently unnamed, it is referred to by a provisional code name in line with MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming) for ease of communication.Formula:C20H23NO5Color and Shape:SolidMolecular weight:357.4Antitumor agent-67
CAS:Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells.Formula:C45H47NO13Color and Shape:SolidMolecular weight:809.85Tubulin inhibitor 25
CAS:Potent Tubulin inhibitor 25: IC50 0.98 μM, blocks HT29 cell growth, hinders cell migration & microtubule formation, anti-angiogenic.Formula:C26H22O8Color and Shape:SolidMolecular weight:462.45Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2
CAS:Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 demonstrates serum stability and non-toxicity to neuronal cells, while selectively inhibiting the fibrilization of tau inFormula:C38H65N11O9Color and Shape:SolidMolecular weight:819.99Valecobulin hydrochloride
CAS:Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516.Cost-effective and quality-assured.Formula:C26H29ClN6O5SPurity:99.52%Color and Shape:SolidMolecular weight:573.06Ref: TM-T13278
1mg84.00€5mg161.00€10mg245.00€25mg406.00€50mg572.00€100mg772.00€200mg1,035.00€1mL*10mM (DMSO)197.00€Tubulin polymerization-IN-32
Tubulin polymerization-IN-32: a cancer cell growth inhibitor used for research in cancers like lymphoma.Formula:C29H30N2O7Color and Shape:SolidMolecular weight:518.56Antitumor agent-200
CAS:Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.Formula:C19H21FN2O3SeColor and Shape:SolidMolecular weight:423.34Tubulin inhibitor 22
Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.Formula:C20H17BrFNO4Color and Shape:SolidMolecular weight:434.26Tubulin inhibitor 15
Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 15 exhibits cytotoxicity in HepG2 cells [1].Formula:C16H12FNO2Color and Shape:SolidMolecular weight:269.27TTBK1/2-IN-3
CAS:TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).Formula:C21H22N4OColor and Shape:SolidMolecular weight:346.426PM-060184
CAS:PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.Formula:C31H45N3O7Purity:98%Color and Shape:SolidMolecular weight:571.7Tubulin polymerization-IN-8
CAS:Compound IIc inhibits tubulin polymerization, arrests cell cycle at G2/M in HCT116 cells, IC50 12.7 μM, potential for cancer research.Formula:C21H24N4O4SColor and Shape:SolidMolecular weight:428.5Epothilone E
CAS:Epothilone E, a derivative of epothilone, functions by inhibiting microtubule protein activity, thereby halting cell division and exhibiting anti-tumorFormula:C26H39NO7SColor and Shape:SolidMolecular weight:509.66AMXI-5001 hydrochloride
AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.Formula:C25H21ClFN5O3Color and Shape:SolidMolecular weight:493.92PROTAC α-synuclein degrader 6
CAS:PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.Formula:C37H39N5O9SMolecular weight:729.80Monomethyl auristatin E intermediate-17
CAS:MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).Formula:C27H35NO7SMolecular weight:517.63TACC3 inhibitor 2
CAS:TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.Formula:C20H22FN5O2Color and Shape:SolidMolecular weight:383.419Tubulin polymerization-IN-77
CAS:Tubulin polymerization-IN-77 (Compound 15c) is a microtubule polymerization inhibitor that exhibits anti-glioblastoma activity by hindering microtubule polymerization. It demonstrates significant blood-brain barrier permeability, effectively induces G2/M phase arrest in GBM cells, and triggers apoptosis, while also markedly inhibiting tumor cell migration.Formula:C22H19BrF3NO7Color and Shape:SolidMolecular weight:546.288Tubulin polymerization-IN-63
CAS:Tubulin polymerization-IN-63 (compound 6) is an inhibitor of tubulin polymerization. It exhibits an IC50 value of 0.29 μM against MES-SA cells, making it suitable for use in cancer research.Formula:C20H24ClCuN5O2SColor and Shape:SolidMolecular weight:497.5TPI-287
CAS:TPI 287: synthetic taxane; may halt cancer by stabilizing microtubules, blocking cell division, inducing apoptosis.Formula:C46H63NO15Color and Shape:SolidMolecular weight:869.99Tubulin polymerization-IN-34
"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."Formula:C31H35N3O6Color and Shape:SolidMolecular weight:545.63Sagopilone
CAS:Sagopilone: synthetic epothilone, inhibits cell division and induces apoptosis, effective in MDR tumors, not P-gp substrate.Formula:C30H41NO6SColor and Shape:SolidMolecular weight:543.71
