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Microtubule Associated

Microtubule Associated

Microtubule-associated protein inhibitors target proteins that interact with microtubules, the structural components of the cell's cytoskeleton that are essential for cell division. These proteins regulate the stability and dynamics of microtubules during mitosis. Inhibiting microtubule-associated proteins can disrupt microtubule function, leading to cell cycle arrest and apoptosis, particularly in rapidly dividing cancer cells. These inhibitors are widely used in cancer research and drug development. At CymitQuimica, we offer a comprehensive range of high-quality microtubule-associated protein inhibitors to support your research in cell division, cytoskeletal dynamics, and cancer therapy.

Found 283 products of "Microtubule Associated"

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  • TCS 2210
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    TCS 2210

    CAS:
    TCS 2210 promotes neuronal differentiation in stem cells, boosting β-III tubulin and enolase markers.
    Formula:C18H17N3O3
    Purity:98.62%
    Color and Shape:Solid
    Molecular weight:323.35

    Ref: TM-T23446

  • DM1-SMe
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    DM1-SMe

    CAS:
    <p>DM1-SMe (DM1-SSMe) potently inhibits microtubules, 3-10x stronger than Maytansine with IC50s of 0.003-0.01 nM in human cancer cells.</p>
    Formula:C36H50ClN3O10S2
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:784.38

    Ref: TM-T21408

  • THK-5105
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    THK-5105

    CAS:
    THK-5105, a tau-binding arylquinoline, could be an 18F-PET imaging probe for Alzheimer's disease.
    Formula:C20H21FN2O2
    Color and Shape:Solid
    Molecular weight:340.39

    Ref: TM-T61087

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    Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2

    CAS:
    <p>Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 demonstrates serum stability and non-toxicity to neuronal cells, while selectively inhibiting the fibrilization of tau in</p>
    Formula:C38H65N11O9
    Color and Shape:Solid
    Molecular weight:819.99

    Ref: TM-T76217

  • ASN90
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    ASN90

    CAS:
    ASN90 is a specific, orally active inhibitor of the O-GlcNAcase (OGA) enzyme, demonstrating an IC50 of 10.2 nM.
    Formula:C17H21N5O3S
    Color and Shape:Solid
    Molecular weight:375.45

    Ref: TM-T79829

  • 3,4',5-Trismethoxybenzophenone
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    3,4',5-Trismethoxybenzophenone

    CAS:
    3,4',5-Trismethoxybenzophenone (compound 16a) is an effective inhibitor of tubulin assembly, demonstrating a half-maximal inhibitory concentration (IC 50) of 2.6 µM [1].
    Formula:C16H16O4
    Color and Shape:Solid
    Molecular weight:272.3

    Ref: TM-T84553

  • JG-23
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    JG-23

    CAS:
    JG-23, a 4-chloro-modified analog, effectively induces t-tau degradation and demonstrates robust metabolic stability, exhibiting an extended half-life (T1/2) of
    Formula:C19H16ClN3OS2
    Color and Shape:Solid
    Molecular weight:401.93

    Ref: TM-T78533

  • Valecobulin hydrochloride
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    Valecobulin hydrochloride

    CAS:
    <p>Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516.Cost-effective and quality-assured.</p>
    Formula:C26H29ClN6O5S
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:573.06

    Ref: TM-T13278

  • N-Deacetylcolchicine
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    N-Deacetylcolchicine

    CAS:
    Trimethylcolchicinic acid methyl ether (HAN 76504), an antimitotic agent, blocks microtubule assembly by attaching to tubulin and inhibiting its polymerization. It enhances tubulin's intrinsic GTPase activity, induces apoptosis across various normal and tumor cell lines, and activates the JNK/SAPK pathway. Currently unnamed, it is referred to by a provisional code name in line with MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming) for ease of communication.
    Formula:C20H23NO5
    Color and Shape:Solid
    Molecular weight:357.4

    Ref: TM-T85194

  • MK-6240
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    MK-6240

    CAS:
    MK-6240: A tau PET tracer with high specificity for NFTs binding.
    Formula:C16H11FN4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:278.28

    Ref: TM-T19429

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    Dolastatinol

    CAS:
    Dolastatinol, a synthetic analog of Dolastatin 10, serves as a potent low-nanomolar inhibitor of tubulin polymerization.
    Formula:C43H70N6O7S
    Color and Shape:Solid
    Molecular weight:815.12

    Ref: TM-T74148

  • CNS-11
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    CNS-11

    CAS:
    CNS-11, a compound that disaggregates tau fibrils, is utilized in Alzheimer's disease (AD) research [1].
    Formula:C25H21N3O2
    Color and Shape:Solid
    Molecular weight:395.45

    Ref: TM-T84812

  • Tubulin inhibitor 25
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    Tubulin inhibitor 25

    CAS:
    Potent Tubulin inhibitor 25: IC50 0.98 μM, blocks HT29 cell growth, hinders cell migration & microtubule formation, anti-angiogenic.
    Formula:C26H22O8
    Color and Shape:Solid
    Molecular weight:462.45

    Ref: TM-T62922

  • Oxaline
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    Oxaline

    CAS:
    Oxaline, a fungal alkaloid derived from Penicillium oxalicum, impedes tubulin polymerization, leading to cell cycle arrest at the M phase [1] [2].
    Formula:C24H25N5O4
    Color and Shape:Solid
    Molecular weight:447.49

    Ref: TM-T85040

  • Tubulin polymerization-IN-52
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    Tubulin polymerization-IN-52

    CAS:
    Tubulin polymerization-IN-52 (compound SC23) effectively inhibits tubulin polymerization, exhibiting an IC50 value of 2.9 μM [1].
    Formula:C21H18F3N5O3
    Color and Shape:Solid
    Molecular weight:445.39

    Ref: TM-T79766

  • PBB3
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    PBB3

    CAS:
    PBB3 is a tau-specific PET tracer.
    Formula:C17H15N3OS
    Color and Shape:Solid
    Molecular weight:309.39

    Ref: TM-T33890

  • Anticancer agent 40
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    Anticancer agent 40

    CAS:
    Anticancer agent 3e targets SKBR-3, SKOV-3, PC-3, U-87 (IC50 ~0.95 nM) and HDF cells (IC50: 2.13 nM).
    Formula:C25H29NO6
    Color and Shape:Solid
    Molecular weight:439.5

    Ref: TM-T62523

  • Antitumor agent-67
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    Antitumor agent-67

    CAS:
    Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells.
    Formula:C45H47NO13
    Color and Shape:Solid
    Molecular weight:809.85

    Ref: TM-T83001

  • Isodienestrol
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    Isodienestrol

    CAS:
    Isodienestrol, a derivative of Diethylstilbestrol, acts as a microtubule (Microtubule) inhibitor. It is utilized in cancer research.
    Formula:C18H18O2
    Color and Shape:Solid
    Molecular weight:266.33

    Ref: TM-T211675

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    Monomethyl auristatin E intermediate-17

    CAS:
    MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).
    Formula:C27H35NO7S
    Molecular weight:517.63

    Ref: TM-T208363