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PLK

PLK

PLK (Polo-like Kinase) inhibitors target PLKs, a family of serine/threonine kinases that are essential for various stages of cell division, including mitotic entry, spindle assembly, and cytokinesis. PLKs are critical for the proper execution of the cell cycle, and their dysregulation is often associated with cancer. Inhibiting PLKs can induce cell cycle arrest and apoptosis in cancer cells, making these inhibitors important tools in cancer research and therapy. At CymitQuimica, we offer a range of high-quality PLK inhibitors to support your research in mitosis, cell cycle control, and oncology.

Found 29 products for "PLK".

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  • Cyclapolin 9
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    Cyclapolin 9

    CAS:
    Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.
    Formula:C9H4F3N3O4S
    Purity:99.64%
    Color and Shape:Yellow Solid
    Molecular weight:307.21

    Ref: TM-T22700

  • Poloxin-2
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    Poloxin-2

    CAS:
    Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.
    Formula:C16H15NO3
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:269.3

    Ref: TM-T25969

  • TC-S 7005
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    TC-S 7005

    CAS:
    TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
    Formula:C21H17N3O3
    Purity:99.51%
    Color and Shape:Solid
    Molecular weight:359.38

    Ref: TM-T17008

  • Plogosertib
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    Plogosertib

    CAS:
    Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.
    Formula:C34H48N8O3
    Purity:99.22% - 99.42%
    Color and Shape:White Solid
    Molecular weight:616.797

    Ref: TM-T71399

  • IIP0943
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    IIP0943

    CAS:
    IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.
    Formula:C26H28N6O3S
    Color and Shape:Solid
    Molecular weight:504.604

    Ref: TM-T206115

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    Y207-5465

    CAS:
    Y207–5465 is a potent and highly selective inhibitor of PLK2 with an IC50 value of 584.3 nM. It exhibits limited anticancer activity in HT-29 and HCT-116 cell lines. Y207–5465 is applicable for cancer research.
    Formula:C20H16N4O3
    Molecular weight:360.37

    Ref: TM-T214775

  • CD 10899
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    CD 10899

    CAS:
    CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].
    Formula:C34H50N8O4
    Color and Shape:Solid
    Molecular weight:634.81

    Ref: TM-T86023

  • PLK1-IN-11
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    PLK1-IN-11

    CAS:
    PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.
    Formula:C12H11N5O
    Color and Shape:Solid
    Molecular weight:241.2486

    Ref: TM-T205548

  • PLK1-IN-5
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    PLK1-IN-5

    CAS:
    PLK1-IN-5, a potent PLK1 inhibitor, has an IC50 of less than 500 nM and demonstrates anticancer effects (WO2008113711A1; compound I-4) [1].
    Formula:C28H39N7O3
    Color and Shape:Solid
    Molecular weight:521.65

    Ref: TM-T87222