CymitQuimica logo
PLK

PLK

PLK (Polo-like Kinase) inhibitors target PLKs, a family of serine/threonine kinases that are essential for various stages of cell division, including mitotic entry, spindle assembly, and cytokinesis. PLKs are critical for the proper execution of the cell cycle, and their dysregulation is often associated with cancer. Inhibiting PLKs can induce cell cycle arrest and apoptosis in cancer cells, making these inhibitors important tools in cancer research and therapy. At CymitQuimica, we offer a range of high-quality PLK inhibitors to support your research in mitosis, cell cycle control, and oncology.

Found 28 products of "PLK"

Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
products per page.
  • Centrinone-B
    Targetmol
    + Info

    Centrinone-B

    CAS:
    <p>Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.</p>
    Formula:C27H27F2N7O5S2
    Purity:98.71%
    Color and Shape:Solid
    Molecular weight:631.67

    Ref: TM-T14926

  • TC-S 7005
    Targetmol
    + Info

    TC-S 7005

    CAS:
    <p>TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).</p>
    Formula:C21H17N3O3
    Purity:99.516%
    Color and Shape:Solid
    Molecular weight:359.38

    Ref: TM-T17008

  • Poloxin-2
    Targetmol
    + Info

    Poloxin-2

    CAS:
    <p>Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.</p>
    Formula:C16H15NO3
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:269.3

    Ref: TM-T25969

  • Plogosertib
    Targetmol
    + Info

    Plogosertib

    CAS:
    <p>Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.</p>
    Formula:C34H48N8O3
    Purity:99.22% - 99.85%
    Color and Shape:Solid
    Molecular weight:616.797

    Ref: TM-T71399

  • PLK1-IN-11
    Targetmol
    + Info

    PLK1-IN-11

    CAS:
    <p>PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.</p>
    Formula:C12H11N5O
    Color and Shape:Solid
    Molecular weight:241.249

    Ref: TM-T205548

  • PLK1-IN-5
    Targetmol
    + Info

    PLK1-IN-5

    CAS:
    <p>PLK1-IN-5, a potent PLK1 inhibitor, has an IC50 of less than 500 nM and demonstrates anticancer effects (WO2008113711A1; compound I-4) [1].</p>
    Formula:C28H39N7O3
    Color and Shape:Solid
    Molecular weight:521.65

    Ref: TM-T87222

  • IIP0943
    Targetmol
    + Info

    IIP0943

    CAS:
    <p>IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.</p>
    Formula:C26H28N6O3S
    Color and Shape:Solid
    Molecular weight:504.604

    Ref: TM-T206115

  • CD 10899
    Targetmol
    + Info

    CD 10899

    CAS:
    <p>CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].</p>
    Formula:C34H50N8O4
    Color and Shape:Solid
    Molecular weight:634.81

    Ref: TM-T86023