HSP
HSP (Heat Shock Protein) inhibitors target HSPs, a family of molecular chaperones that assist in protein folding, stability, and protection against stress-induced damage. HSPs are often upregulated in cancer cells, helping them survive under stressful conditions such as hypoxia and chemotherapy. Inhibiting HSPs can disrupt these protective mechanisms, leading to cell death. HSP inhibitors are therefore valuable in cancer therapy and research into stress responses. At CymitQuimica, we provide a comprehensive range of high-quality HSP inhibitors to support your research in protein homeostasis, stress responses, and oncology.
Found 176 products for "HSP".
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JD-13
CAS:JD-13 is a selective GPR119 agonist; promotes insulin and GLP-1 release; glucose homeostasis; diabetes research tool.Formula:C25H32N4O3Purity:99.32% - 99.69%Color and Shape:White SolidMolecular weight:436.56Alvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Formula:C34H49F3N4O10Color and Shape:SolidMolecular weight:730.34008HEMTAC WEE1 degrader-1
CAS:HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Formula:C57H71N15O6Color and Shape:SolidMolecular weight:1062.27HA15-Biotin
CAS:HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.Formula:C37H45N7O5S3Color and Shape:SolidMolecular weight:763.99TRAP1-IN-1
CAS:TRAP1-IN-1 is a selective TRAP1 inhibitor, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.Formula:C45H39F7N2O4P2Purity:98%Color and Shape:White SolidMolecular weight:866.74Hsp110-STAT3 interaction-IN-2
Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).Formula:C24H18F3N5O3Color and Shape:SolidMolecular weight:481.43A17 peptide
CAS:A17 peptide is an Hsp70-targeting peptide. It binds to the ATP-binding domain of Hsp70, specifically inhibiting its chaperone activity. This enhances cellular sensitivity to chemotherapeutic drugs, such as those inducing apoptosis via Cisplatin. A17 peptide is applicable in cancer chemotherapy research, including studies on multiple myeloma.Formula:C76H105N19O20SColor and Shape:SolidMolecular weight:1636.83CCT245232
CAS:CCT245232 is a potent HSF1 inhibitor, possibly used for researching cancer.Formula:C27H23N3O4Color and Shape:SolidMolecular weight:453.49PU-H71
CAS:PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.Formula:C18H21IN6O2SPurity:98.31% - 99.93%Color and Shape:White SolidMolecular weight:512.37Palmitic acid-1-13C
CAS:Palmitic acid-13C, a 16-C saturated fatty acid internal standard for GC/LC-MS, is prevalent in plasma lipids and influences protein acylation and COX-2 levels.Formula:C16H32O2Color and Shape:SolidMolecular weight:257.422Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Formula:C22H30N6O2SPurity:98.98%Color and Shape:White SolidMolecular weight:442.58Alvespimycin hydrochloride
CAS:Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.Formula:C32H48N4O8·HClPurity:99.85% - 99.94%Color and Shape:Purple SolidMolecular weight:653.21VER49009
CAS:VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).Formula:C19H18ClN3O4Purity:99.24% - >99.99%Color and Shape:White SolidMolecular weight:387.82Ref: TM-T2268
1mg57.00€2mg80.00€1mL*10mM (DMSO)90.00€5mg105.00€10mg164.00€25mg268.00€50mg447.00€100mg610.00€YUM70
CAS:YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.Formula:C21H19ClN2O4Purity:97.25%Color and Shape:White SolidMolecular weight:398.84Ref: TM-T8901
1mg46.00€1mL*10mM (DMSO)90.00€5mg92.00€10mg128.00€25mg250.00€50mg369.00€100mg525.00€200mg710.00€HSF1A
CAS:HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.Formula:C21H19N3O2S2Purity:98.89%Color and Shape:SolidMolecular weight:409.52Ref: TM-T4125
1mg52.00€2mg94.00€1mL*10mM (DMSO)123.00€5mg132.00€10mg195.00€25mg439.00€50mg642.00€100mg888.00€XL888
CAS:XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.Formula:C29H37N5O3Purity:99.18%Color and Shape:SolidMolecular weight:503.64Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Formula:C29H31NO7Purity:95.32% - 99.67%Color and Shape:SolidMolecular weight:505.56Ref: TM-TQ0131
500µg155.00€1mg187.00€5mg410.00€1mL*10mM (DMSO)449.00€10mg710.00€25mg1,381.00€50mg2,352.00€HM03 trihydrochloride
CAS:HM03 trihydrochloride is a potent and selective inhibitor of HSPA5, also known as Bip or Grp78. It exhibits anticancer activity.Formula:C26H30Cl4N4O2Color and Shape:SolidMolecular weight:572.35Teprenone
CAS:Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).Formula:C23H38OPurity:99.1% - 99.96%Color and Shape:SolidMolecular weight:330.55MK2-IN-1 hydrochloride
CAS:MK2-IN-1 hydrochloride (MK 25) selectively inhibits MK2 with IC50 of 0.11 μM, non-ATP competitive.Formula:C27H26Cl2N4O2Purity:97.32%Color and Shape:SolidMolecular weight:509.43
