Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2613 products of "Chromatin/Epigenetics"
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TMPA
CAS:TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.Formula:C21H32O6Purity:99.21%Color and Shape:SolidMolecular weight:380.48Ref: TM-T13173
1mg75.00€5mg164.00€10mg260.00€25mg440.00€50mg620.00€100mg964.00€1mL*10mM (DMSO)167.00€GSK-1268997
CAS:GSK-1268997 is a bio-active chemical.Formula:C21H23N7O3SPurity:99.33% - 99.81%Color and Shape:SolidMolecular weight:453.52TAK-285
CAS:TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Formula:C26H25ClF3N5O3Purity:99.73%Color and Shape:SolidMolecular weight:547.96Ref: TM-T6039
1mg38.00€5mg80.00€10mg120.00€25mg216.00€50mg354.00€100mg512.00€200mg727.00€1mL*10mM (DMSO)96.00€GW843682X
CAS:GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).Formula:C22H18F3N3O4SPurity:99.92%Color and Shape:SolidMolecular weight:477.46UNC0224
CAS:UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.Formula:C26H43N7O2Purity:99.80%Color and Shape:SolidMolecular weight:485.67MY-1B
CAS:MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.Formula:C22H18BrN3O2Purity:99.81% - >99.99%Color and Shape:SoildMolecular weight:436.3CPI-4203
CAS:CPI-4203 is a selective inhibitor of KDM5 demethylases.Formula:C16H14N4OColor and Shape:SolidMolecular weight:278.31BPTF-IN-1
CAS:BPTF-IN-1 (AU1), a BPTF bromodomain inhibitor with 2.8 μM affinity, shows higher selectivity over BRD4 and possesses antimalarial properties.Formula:C23H23FN6O3Color and Shape:SolidMolecular weight:450.47(Rac)-BAY1238097
CAS:(Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.Formula:C25H33N5O3Purity:98%Color and Shape:SolidMolecular weight:451.56NSC-311068
CAS:NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.Formula:C10H6N4O4SColor and Shape:SolidMolecular weight:278.24HDAC6-IN-11
CAS:HDAC6-IN-11 (Compound 9) is a cancer cell growth blocker, selectively inhibiting HDAC6 (>300-fold) with an IC50 of 20.7 nM.Formula:C19H16N2O4Color and Shape:SolidMolecular weight:336.34NCD38
CAS:NCD38 is a potent, selective LSD1 inhibitor.Formula:C37H37ClF3N3O4Purity:98.21% - 98.86%Color and Shape:SolidMolecular weight:680.16JAK-IN-11
CAS:JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.Formula:C23H22FN5O4SPurity:99.75%Color and Shape:SolidMolecular weight:483.52Aurora A/PKC-IN-1
CAS:Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.Formula:C16H14N6OSe2Color and Shape:SolidMolecular weight:464.24JNJ-9350
CAS:JNJ-9350: SMOX inhibitor (IC50 0.01 μM), PAO inhibitor (IC50 0.79 μM), for cancer research.Formula:C25H22N6OColor and Shape:SolidMolecular weight:422.48HPB
CAS:HPB is a selective HDAC6 deacetylase inhibitorFormula:C18H20N2O4Color and Shape:SolidMolecular weight:328.36ZIKV-IN-3
CAS:ZIKV-IN-3, an andrographolide derivative, inhibits ZIKV NS5 MTase (IC50: 18.34 μM) and replication. Used for Zika virus research.Formula:C39H41NO4Color and Shape:SolidMolecular weight:587.75NVS-BET-1
CAS:NVS-BET-1 is a BET bromodomain inhibitor. NVS-BET-1 can regulate keratinocyte plasticity.Formula:C22H21ClN4O2Color and Shape:SolidMolecular weight:408.88HIF-1α-IN-3
CAS:HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].Formula:C19H17N5O2Color and Shape:SolidMolecular weight:347.37PF-739
CAS:PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.Formula:C23H23ClN2O5Purity:98%Color and Shape:SolidMolecular weight:442.89HDAC-IN-29
CAS:HDAC-IN-29 (compound 13b) is a potent pan- HDAC inhibitor with antitumor activity.Formula:C20H23N3O4SColor and Shape:SolidMolecular weight:401.48EML741
CAS:EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.Formula:C31H49N5O2Purity:98%Color and Shape:SolidMolecular weight:523.75HDAC1-IN-4
CAS:HDAC1-IN-4 is a potent inhibitor of Plasmodium falciparum HDAC1 (PfHDAC1) with low cytotoxicity and antimalarial effects (IC50<5 nM).Formula:C21H24BrClN6O2Color and Shape:SolidMolecular weight:507.82YUKA1
CAS:YUKA1, a cell-permeable KDM5A inhibitor with a weak effect on KDM5C, increase H3K4me3 and inhibit the proliferation, prevent drug-resistant.Formula:C13H16N4O2SPurity:99.85%Color and Shape:SolidMolecular weight:292.36Ref: TM-T17278
1mg105.00€5mg250.00€10mg409.00€25mg802.00€50mg1,224.00€100mg1,783.00€200mg2,457.00€1mL*10mM (DMSO)268.00€Setin-1
CAS:Setin-1 is the most potent Set7 inhibitor that acts by inhibiting the KMTase G9a.Formula:C29H21F3N2O2Purity:98%Color and Shape:SolidMolecular weight:486.48GSK 525768A
CAS:GSK 525768A, the inactive enantiomer of GSK525762A, exhibits no activity towards BET.Formula:C22H22ClN5O2Color and Shape:SolidMolecular weight:423.9OXFBD03
CAS:OXFBD03 is the bromodomain and extra terminal domain bromodomain family member BRD4(1) inhibitor.Formula:C20H19NO4Purity:98%Color and Shape:SolidMolecular weight:337.37LY 170198
CAS:LY 170198 is a protein kinase C inhibitor.Formula:C22H25N5O5Purity:98%Color and Shape:SolidMolecular weight:439.46DHPCC-9
CAS:DHPCC-9 is an inhibitor of Pim kinase.Formula:C15H10N2OColor and Shape:SolidMolecular weight:234.25DC_501
CAS:DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.Formula:C25H23Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:452.38DCE_254
CAS:DCE_254 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.Formula:C21H17N9OSPurity:98%Color and Shape:SolidMolecular weight:443.48Langkamide
CAS:Langkamide is a HIF-2 inhibitor with EC₅₀ values of 14.0 uM.Formula:C16H17NO5Purity:98%Color and Shape:SolidMolecular weight:303.31Aurora kinase inhibitor-10
CAS:Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.Formula:C21H19F5N6O4SColor and Shape:SolidMolecular weight:546.47BF1
CAS:BF1 is an inhibitor of HAT (histone acetyltransferase) active both in vitro and in vivo.Formula:C12H12ClN3SColor and Shape:SolidMolecular weight:265.76Farnesylthiotriazole
CAS:Farnesylthiotriazole is a persistent PKC activator agent.Formula:C17H27N3SPurity:98%Color and Shape:SolidMolecular weight:305.48Tenovin-D3
CAS:Tenovin-D3 is a sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner.Formula:C22H27Cl3N4O3SPurity:98%Color and Shape:SolidMolecular weight:533.9ML399
CAS:ML399 inhibits menin–MLL interaction, selectively blocking oncogenic MLL signaling in leukemia cells, supporting functional genomics and therapeutic research.Formula:C27H28FN3O2Purity:97.84% - 98.20%Color and Shape:SolidMolecular weight:445.53HIF-IN-33
CAS:HIF-IN-33 is an inhibitor of HIF pathway.Formula:C21H17F3N4O2Purity:98%Color and Shape:SolidMolecular weight:414.38BET-BAY 002
CAS:BET-BAY 002 is an effective BET bromodomain inhibitor demonstrating efficacy in vivo and in vitro against multiple myeloma and leukaemia models.Formula:C22H18ClN5OColor and Shape:SolidMolecular weight:403.86Fagaronine chloride
CAS:Fagaronine chloride is a potent inhibitor of Topoisomerases I.Formula:C21H20ClNO4Color and Shape:SolidMolecular weight:385.84MT477
CAS:MT477 inhibits PKC-α, impairs Ras/ERK1/2 phosphorylation, induces apoptosis, and reduces proliferation in various cancer cells.Formula:C31H30N2O12S3Color and Shape:SolidMolecular weight:718.77Lobelane Hydrochloride
CAS:Lobelane Hydrochloride is a vesicular monoamine transporter-2 (VMAT2) inhibitor.Formula:C22H30ClNColor and Shape:SolidMolecular weight:343.93SirReal-1
CAS:SirReal-1 is an effective and selective inhibitor of Sirt2.Formula:C18H18N4OS2Purity:98%Color and Shape:SolidMolecular weight:370.49Prospasmine
CAS:Prospasmine is an anticholinergic.Formula:C17H28ClNO2Purity:98%Color and Shape:SolidMolecular weight:313.87KF 13218
CAS:KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.Formula:C20H20N2O3Purity:98%Color and Shape:SolidMolecular weight:336.38Hns 32
CAS:Hns 32 possesses antiarrhythmic properties in dog and guinea pig hearts. It also has vasodilator action.Formula:C24H29N3Purity:98%Color and Shape:SolidMolecular weight:359.51Rucaparib camsylate
CAS:Rucaparib camsylate, a PARP-1, -2, -3 inhibitor (Ki=1.4 nM for PARP-1) & H6PD blocker, may treat resistant prostate cancer.Formula:C19H18FN3O·xC10H16O4SColor and Shape:SolidHIF-PHD-IN-2
CAS:HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].Formula:C17H15N5O3SColor and Shape:SolidMolecular weight:369.4Y08284
CAS:Y08284: selective CBP bromodomain inhibitor, IC50: 4.21 nM, oral. Halts prostate cancer cell growth; anti-tumor.Formula:C26H25FN4O4Color and Shape:SolidMolecular weight:476.5GSK926
CAS:GSK926 is a selective, SAM-competitive, and cell-active EZH2 inhibitor.Formula:C29H35N7O2Color and Shape:SolidMolecular weight:513.63Y06036
CAS:Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).Formula:C16H15BrN2O5SPurity:99.97%Color and Shape:SolidMolecular weight:427.27CREBBP-IN-9
CAS:CREBBP-IN-9, a CREBBP inhibitor, acts on the bromodomain of the protein.Formula:C16H15N5O2SPurity:98%Color and Shape:SolidMolecular weight:341.39Bizine
CAS:Bizine, a Phenelzine analogue, selectively inhibits LSD1 (Ki=59 nM), modulates histone methylation in cancer, and may have neuroprotective uses.Formula:C18H23N3OColor and Shape:SolidMolecular weight:297.39M133
CAS:M133 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.Formula:C23H24N4OS2Color and Shape:SolidMolecular weight:436.59Peficitinib hydrobromide
CAS:Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.Formula:C18H23BrN4O2Color and Shape:SolidMolecular weight:407.312H8-A5
CAS:H8-A5, a HDAC8 inhibitor, shows antiproliferation activity in MDA-MB-231 cancer cells.Formula:C14H9F3N2O2SPurity:98%Color and Shape:SolidMolecular weight:326.29Arazine
CAS:Arazine, a cell-permeable G protein modulator, is an isoprenylcysteine methyltransferase substrate.Formula:C20H33NO3SPurity:90%Color and Shape:SolidMolecular weight:367.55Thi-DPPY
CAS:Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.Formula:C28H28ClN5O4SColor and Shape:SolidMolecular weight:566.07MS453
CAS:MS453 is a potent and selective SETD8 inhibitor with an IC50 value of 804 nM.Formula:C20H27N5O3Color and Shape:SolidMolecular weight:385.46HIF-1/2α-IN-2
CAS:HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.Formula:C16H11FN4O2SColor and Shape:SolidMolecular weight:342.35SIRT2-IN-11
CAS:SIRT2-IN-11 (AEM1), a SIRT2 inhibitor (IC50 18.5μM), induces apoptosis and affects p53, used in cancer research.Formula:C21H22N2OColor and Shape:SolidMolecular weight:318.41Galegine hydrochloride
CAS:Galegine hydrochloride, from G. officinalis, leads to weight loss, activates AMPK in various cells, and has antibacterial properties.Formula:C6H14ClN3Color and Shape:SolidMolecular weight:163.651,2-Didecanoylglycerol
CAS:1,2-Didecanoylglycerol has functions as bioregulator of protein kinase C in human platelets.Formula:C23H44O5Color and Shape:SolidMolecular weight:400.59KDM2B-IN-3
CAS:KDM2B-IN-3, from patent WO2016112284A1 as compound 183c, potently inhibits histone demethylase KDM2B, with cancer research potential.Formula:C25H30N2O2Color and Shape:SolidMolecular weight:390.52JNJ-7925476 free base
CAS:JNJ-7925476 is an TRI antidepressant agent.Formula:C20H19NPurity:98%Color and Shape:SolidMolecular weight:273.37PRMT5-IN-2
CAS:PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.Formula:C17H16ClFN4O4Purity:98%Color and Shape:SolidMolecular weight:394.78J1075
CAS:J1075 is an histone deacetylase 8 (HDAC8) inhibitor.Formula:C9H6ClNO2SPurity:98%Color and Shape:SolidMolecular weight:227.67S-Aristeromycinylhomocysteine
CAS:S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase.Formula:C15H22N6O4SColor and Shape:SolidMolecular weight:382.44(R)-OR-S1
CAS:(R)-OR-S1 is a SAM-competitive, highly selective, orally bioavailable dual inhibitor of EZH1/2.Formula:C26H34BrN3O4Purity:98%Color and Shape:SolidMolecular weight:532.47Acefylline piperazine
CAS:Acefylline piperazine, a less toxic theophylline derivative, treats asthma and bronchitis by bronchodilation, stimulating respiration and CNS.Formula:C9H10N4O4·xC4H10N2Color and Shape:SolidMolecular weight:562.54MI-3
CAS:MI-3 (Menin-MLL Inhibitor) (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM).Formula:C18H25N5S2Purity:98.66% - 99.61%Color and Shape:SolidMolecular weight:375.55ZLD10A
CAS:ZLD10A is a highly potent and selective small molecule inhibitor of EZH2.Formula:C37H48N4O4Purity:98%Color and Shape:SolidMolecular weight:612.8WAY-260022
CAS:WAY-260022 is the norepinephrine transporter inhibitor.Formula:C21H31F3N2O2Purity:97.61% - 99.41%Color and Shape:SolidMolecular weight:400.48BNS
CAS:BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.Formula:C18H16N2O6S2Purity:98%Color and Shape:SolidMolecular weight:420.46NR-160
CAS:NR-160 is a selective HDAC6 inhibitor (IC50=0.03μM), weaker on HDAC1-4,8, toxic to 7 cancer lines, boosts bortezomib and anthracycline effects.Formula:C25H21F3N6O3Color and Shape:SolidMolecular weight:510.47Ro 31-8830
CAS:Ro 31-8830, a derivative of Ro 31-8425, has in vivo anti-inflammatory activity.Formula:C28H28N4O2Purity:98%Color and Shape:SolidMolecular weight:452.55S2101
CAS:S2101 is a specific LSD1 histone demethylase inhibitor with an IC50 of 0.99 μM and a Ki of 0.61 μM, suitable for research into cancer and viral infections.Formula:C16H16ClF2NOPurity:98%Color and Shape:SolidMolecular weight:311.75LEM-14-1189
CAS:LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood diseases.Formula:C35H34N6O5S2Purity:98.06%Color and Shape:SolidMolecular weight:682.81BRD4-BD1-IN-2
CAS:BRD4-BD1-IN-2: Potent, selective BRD4-BD1 inhibitor, IC50=2.51µM; 20x less active on BD2; for cardiovascular/cancer research.
Formula:C20H15Br3N4O2Purity:99.39%Color and Shape:SolidMolecular weight:583.07NCGC00247743
CAS:NCGC00247743 is an inhibitor of histone lysine demethylase KDM4.Formula:C24H29N3O2Purity:98%Color and Shape:SolidMolecular weight:391.51ST7710AA1
CAS:ST7710AA1 inhibits PARP-1, effectively targets in vitro, and overcomes Pgp-associated multidrug resistance.Formula:C20H22N4OColor and Shape:SolidMolecular weight:334.41SIRT5 inhibitor 2
CAS:SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.Formula:C18H12Cl2N2O3SPurity:99.38% - 99.87%Color and Shape:SolidMolecular weight:407.27JAK-IN-18
CAS:"JAK-IN-18: potent JAK inhibitor for eye, skin, respiratory disease research (WO2018204238A1, comp 1)."Formula:C27H28F2N6O3Color and Shape:SolidMolecular weight:522.55INCB054329 Racemate
CAS:INCB054329 Racemate is an inhibitor of BET protein.Formula:C19H16N4O3Purity:98%Color and Shape:SolidMolecular weight:348.36AMPK activator 12
CAS:AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.Formula:C23H24BrNO2Purity:99.55%Color and Shape:SolidMolecular weight:426.35RSC-133
CAS:promotes the reprogramming of human somatic cells to pluripotent stem cellsFormula:C18H15N3O2Purity:98%Color and Shape:SolidMolecular weight:305.33BET-IN-2
CAS:BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1).Formula:C23H29N3OPurity:98%Color and Shape:SolidMolecular weight:363.5INO-1001 methanesulfonate
CAS:INO-1001 methanesulfonate is a strong PARP inhibitor with chemosensitization and radiosensitization effects.Formula:C24H29N3O7S2Color and Shape:SolidMolecular weight:535.63UMB-136
CAS:UMB-136 is a bromodomain BRD4 inhibitor that acts by significantly inducing HIV-1 reactivation.Formula:C24H27N5O2Purity:98%Color and Shape:SolidMolecular weight:417.5(R)-BAY1238097
CAS:(R)-BAY1238097 is a selective inhibitor against the binding of BET proteins to histones, used in acute myeloid leukemia (AML) and multiple myeloma (MM) studies.Formula:C25H33N5O3Purity:98.77%Color and Shape:SolidMolecular weight:451.56Ref: TM-T13442
1mg49.00€5mg101.00€10mg172.00€25mg355.00€50mg620.00€100mg1,044.00€200mg1,404.00€1mL*10mM (DMSO)113.00€D 595
CAS:D595 is a phenethylamine-type calcium channel blocker. The most potent phenylethylamine with respect to negative inotropy was D595 (EC50: 794 nmol/l).Formula:C25H32Cl2N2O2Purity:98%Color and Shape:SolidMolecular weight:463.44KDM5-C49
CAS:KDM5-C49 is a potent and selective inhibitor of KDM5, which regulates cell proliferation and stem cell self-renewal and differentiation.Formula:C15H24N4O3Purity:98%Color and Shape:SolidMolecular weight:308.38RET-IN-19
CAS:RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.Formula:C28H28N6O4SColor and Shape:SolidMolecular weight:544.62AMPK activator 8
CAS:AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.Formula:C25H21ClN2O6Color and Shape:SolidMolecular weight:480.9DFPM
CAS:DFPM activates plant resistance, inhibits root growth, reduces Col-0 root cell viability, and is light-sensitive in water.Formula:C16H15Cl2NOSColor and Shape:SolidMolecular weight:340.27Metformin icosapent
CAS:Metformin icosapent activates AMPK, enhancing insulin sensitivity and reducing glucose absorption for better glycemic control.Formula:C24H41N5O2Color and Shape:SolidMolecular weight:431.62CK2/PIM1-IN-1
CAS:CK2/PIM1-IN-1 inhibits CK2 & PIM1 (IC50s: 3.787 & 4.327 μM), aimed for cancer research.Formula:C15H9NO4S2Purity:98%Color and Shape:SolidMolecular weight:331.37EZH2-IN-3
CAS:EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.Formula:C27H28ClN5O2Purity:98%Color and Shape:SolidMolecular weight:490UL04
CAS:UL04 is an inhibitor of CREBBP bromodomain.Formula:C18H17NO5Color and Shape:SolidMolecular weight:327.33TNKS-IN-41
CAS:TNKS-IN-41 highly potent and selective inhibitor of tankyrase.Formula:C24H22N10O2Purity:98%Color and Shape:SolidMolecular weight:482.5
