Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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PROTAC BRD4 Degrader-9
CAS:<p>PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.</p>Formula:C59H71F2N9O15S4Color and Shape:SolidMolecular weight:1312.5BRD4 degrader-6
CAS:<p>BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.</p>Formula:C61H71BClN9O7S2Color and Shape:SolidMolecular weight:1152.67MS049 2HCl (1502816-23-0(free base))
<p>MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.</p>Formula:C15H26Cl2N2OPurity:99.9%Color and Shape:SolidMolecular weight:321.28ZXH-3-26
CAS:<p>ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.</p>Formula:C38H37ClN8O7SPurity:98.90% - 98.90%Color and Shape:SolidMolecular weight:785.27PRMT5-IN-12
CAS:<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Formula:C32H40N4O4Color and Shape:SolidMolecular weight:544.696PI3Kα/HDAC6-IN-1
<p>PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.</p>Formula:C27H30F3N7O6S2Purity:98%Color and Shape:SolidMolecular weight:669.7Sirtuin modulator 5
CAS:<p>Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.</p>Formula:C24H23N3O4Color and Shape:SolidMolecular weight:417.46MAK-683 hydrochloride
CAS:<p>MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.</p>Formula:C20H18ClFN6OPurity:97.02% - >99.99%Color and Shape:SolidMolecular weight:412.85GSK9311 hydrochloride
CAS:<p>GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).</p>Formula:C24H32ClN5O3Purity:98%Color and Shape:SolidMolecular weight:474Thalidomide-NH-CBP/p300 ligand 2
CAS:<p>Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).</p>Formula:C48H57F2N11O6Color and Shape:SolidMolecular weight:922.052SR-0813
CAS:<p>SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9.</p>Formula:C25H32N6O3SPurity:98.81%Color and Shape:SolidMolecular weight:496.62KAT6-IN-2
<p>KAT6-IN-2 is a potent inhibitor of KAT6, showing promise for use in cancer research.</p>Color and Shape:Odour SolidPROTAC BRD4 Degrader-30
<p>PROTACBRD4 degrader-30 is an ISOX-DUAL-based PROTAC degrader, targeting BRD4 with an IC50 value of 65 nM. It is used in research studies related to c-Myc oncoproteins and the pathophysiology of cancer cells.</p>Color and Shape:Odour SolidAnemonin (6CI)
CAS:<p>Anemonin, a furanone dimer from Buttercups, may help manage melanocytes and osteoarthritis.</p>Formula:C10H8O4Color and Shape:SolidMolecular weight:192.17GNE-987
CAS:<p>GNE-987 is a potent chimeric BET degrader, binding BRD4 BD1/BD2 at IC50: 4.7/4.4 nM & has a DC50: 0.03 nM in EOL-1 AML cells.</p>Formula:C56H67F2N9O8S2Purity:98%Color and Shape:SolidMolecular weight:1096.31MRS2698
CAS:<p>MRS2698: potent P2Y2 agonist, EC50 8 nM, >300x selectivity over P2Y4/P2Y6.</p>Formula:C9H16N3O13P3SPurity:98%Color and Shape:SolidMolecular weight:499.22PROTAC SMARCA2/4-degrader-25
<p>PROTAC SMARCA2/4-degrader-25 is a PROTAC that targets SMARCA2/4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2/4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.</p>Formula:C44H50N10O9S2Color and Shape:SolidMolecular weight:927.06PF-04577806
CAS:<p>PF-04577806: potent & selective PKC inhibitor, ATP competitive, blocks PKCα/βI/βII/γ/θ (IC50: 2.4-45.9 nM), may reverse diabetic retinal leakage.</p>Formula:C26H37N7O3Color and Shape:SolidMolecular weight:495.628JB300
CAS:<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Formula:C43H45ClFN7O10SColor and Shape:SolidMolecular weight:906.375EXQ-2d
<p>EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.</p>Formula:C18H17N3O3Color and Shape:SolidMolecular weight:323.35
