Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2441 products of "Chromatin/Epigenetics"
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Y06137
CAS:<p>Y06137, selective BET inhibitor, Kd 81 nM for BRD4(1), researched for castration-resistant prostate cancer treatment.</p>Formula:C27H32N4O2Purity:99.85%Color and Shape:SolidMolecular weight:444.57TY-011
CAS:TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Formula:C18H16ClN5Color and Shape:SolidMolecular weight:337.81AJI-214
CAS:AJI-214 functions as a dual-target inhibitor that specifically blocks Aurora kinase A and JAK2. By directly inhibiting Aurora kinase A, AJI-214 prevents mitotic progression and cell polarity in T cells while concurrently suppressing JAK2 activation to reduce STAT3 phosphorylation. This inhibition decreases the differentiation of TH1 and TH17 cells. AJI-214 is utilized in research focused on the modulation of immune responses and the prevention of graft-versus-host disease (GVHD).Formula:C17H13ClFN5OColor and Shape:SolidMolecular weight:357.77G-631
CAS:G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.Formula:C19H22F2N6O3Color and Shape:SolidMolecular weight:420.41PARP1/2-IN-4
CAS:PARP1/2-IN-4 (compound 3) is an inhibitor of PARP1/2.Formula:C23H30FN5O6Color and Shape:SolidMolecular weight:491.51(Rac)-RG108
CAS:<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Formula:C19H14N2O4Color and Shape:SolidMolecular weight:334.326BRD4-IN-7
CAS:BRD4-IN-7, also known as compound 120, acts as a BRD4 inhibitor.Formula:C29H24F2N4O3Color and Shape:SolidMolecular weight:514.52PRMT5-IN-50
CAS:PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.Formula:C26H23F3N6OColor and Shape:SolidMolecular weight:492.496BRD4 Inhibitor-33
CAS:BRD4 Inhibitor-33 (example 13), a potent inhibitor of BRD4, is applicable in research related to both acute and chronic kidney diseases [1].Formula:C24H20N4O2Color and Shape:SolidMolecular weight:396.44PRMT5-IN-49
CAS:PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.Formula:C19H22N2O2Color and Shape:SolidMolecular weight:310.39NSD2-PWWP1-IN-2
CAS:NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.Formula:C29H30N4Color and Shape:SolidMolecular weight:434.575NVS-BPTF-1
CAS:NVS-BPTF-1 is a specific inhibitor of bromodomain and PHD finger containing transcription factor (BPTF), exhibiting a dissociation constant (K_D) of 71 nM [1].Formula:C26H28FN7O3SColor and Shape:SolidMolecular weight:537.61SRI-43265
CAS:SRI-43265 (compound 40) inhibits the dimerization of human antigen R protein (HuR), which is involved in cancer and inflammation pathogenesis [1].Formula:C19H20N6OColor and Shape:SolidMolecular weight:348.4HYDAMTIQ
CAS:HYDAMTIQ, a PARP-1/2 inhibitor (IC 50 : 29-38 nM), exhibits a range of pharmacological effects including anticancer, anti-inflammatory, and ischemic protective properties. It effectively reduces pulmonary PARP activity and alleviates symptoms such as allergen-induced cough and dyspnea while also diminishing bronchial hyperresponsiveness to methacholine. Moreover, HYDAMTIQ shows potent tumor suppressor activity in various cancers such as ovarian, breast, prostate, pancreatic, and glioblastoma multiforme. Demonstrating in vivo efficacy, HYDAMTIQ has been tested in animal models for conditions like cerebral ischemia, asthma, and cancer [1].Formula:C14H14N2O2SColor and Shape:SolidMolecular weight:274.34PRMT5-IN-37
CAS:PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.Formula:C21H15F4N5O2Color and Shape:SolidMolecular weight:445.37STR-V-53
CAS:STR-V-53, an HDAC inhibitor (IC50 in nM), increases histone acetylation in tumor cells by inhibiting these enzymes, thereby regulating gene expression. STR-V-53 inhibits tumor growth and induces apoptosis [1].Formula:C21H30N4O8Color and Shape:SolidMolecular weight:466.48YEATS4 binder-1
YEATS4 binder-1(4e) is an effective and selective compound that targets the KAc recognition site within the YEATS structural domain, exhibiting a bindingFormula:C23H34N4O3Color and Shape:SolidMolecular weight:414.54CARM1-IN-3 dihydrochloride
CARM1-IN-3 dihydrochloride (17b) is a potent CARM1 inhibitor (IC50: 0.07 μM) with selectivity over CARM3 (IC50 >25 μM).Formula:C24H34Cl2N4O2Color and Shape:SolidMolecular weight:481.46HDAC3-IN-3
CAS:HDAC3-IN-3 (compound 31), a potent inhibitor of HDAC3, holds potential for cancer research [1].Formula:C26H22N4O2Color and Shape:SolidMolecular weight:422.48BRD4 Inhibitor-32
CAS:BRD4 Inhibitor-32 (example 15), a BRD4 inhibitor, is applicable in research pertaining to both acute and chronic kidney disease [1].Formula:C26H25N3O3Color and Shape:SolidMolecular weight:427.5
