Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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O-Desmethyl Midostaurin
CAS:<p>O-Desmethyl Midostaurin is the active Midostaurin metabolite via cytochrome P450 liver enzyme metabolism.</p>Formula:C34H28N4O4Purity:98%Color and Shape:SolidMolecular weight:556.61SMARCA2-IN-6
CAS:<p>SMARCA2-IN-6 is a potent inhibitor of SMARCA2 (also known as BRM), exhibiting an IC50 of less than 5 nM against both SMARCA2 and SMARCA4. Additionally, this compound suppresses the expression of the KRT80 gene in H1299 cells with an IC50 of 26 nM and inhibits the proliferation of SKMEL5 cells carrying a BRG1 mutation with an IC50 value of 13 nM.</p>Formula:C10H8ClF2N5OSColor and Shape:SolidMolecular weight:319.72MS8511
CAS:<p>MS8511: Selective, irreversible G9a/GLP inhibitor. IC50: 100 nM (G9a), 140 nM (GLP). Lowers H3K9me2, anti-proliferative. Useful in cancer/AD/PWS research.</p>Formula:C28H41N5O3Color and Shape:SolidMolecular weight:495.66PARP7-IN-12
CAS:<p>PARP7-IN-12, a potent inhibitor targeting PARP7, exhibits an IC50 of 7.836 nM. This compound is applicable in cancer research.</p>Formula:C23H27ClF3N5O5Color and Shape:SolidMolecular weight:545.94FNDR-20123
<p>FNDR-20123: First safe, effective anti-malarial HDAC inhibitor for Plasmodium (IC50: 31 nM) & human HDACs, with nanomolar potency across several subtypes.</p>Formula:C21H24ClN5O2Color and Shape:SolidMolecular weight:413.9CBP/p300-IN-16
<p>CBP/p300-IN-16 (compound 1) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.61 μM) and LK2 H3K27 (IC50: 2.24 μM).</p>Formula:C26H31N3O4Color and Shape:SolidMolecular weight:449.54SIRT1-IN-5
CAS:<p>SIRT1-IN-5 (215) is a modulator of the NAD-dependent protein deacetylase SIRT1.</p>Formula:C21H17N3O3SColor and Shape:SolidMolecular weight:391.443Tyk2-IN-3
CAS:<p>Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).</p>Formula:C25H24N6O3S2Purity:98%Color and Shape:SolidMolecular weight:520.63BET-IN-1
<p>BET-IN-1 is a potent inhibitor of BET, exhibiting good brain permeability and a reasonable metabolic stability.</p>Formula:C23H24ClFN4O3SColor and Shape:SolidMolecular weight:490.98JAK3-IN-11
CAS:<p>JAK3-IN-11: potent oral JAK3 inhibitor (IC50=1.7 nM), noncytotoxic, >588-fold selectivity, blocks T-cell growth; useful in autoimmune research.</p>Formula:C23H23N5O2Color and Shape:SolidMolecular weight:401.46CARM1-IN-3 dihydrochloride
<p>CARM1-IN-3 dihydrochloride (17b) is a potent CARM1 inhibitor (IC50: 0.07 μM) with selectivity over CARM3 (IC50 >25 μM).</p>Formula:C24H34Cl2N4O2Color and Shape:SolidMolecular weight:481.46KDOAM-25 trihydrochloride
<p>KDOAM-25 trihydrochloride selectively inhibits KDM5 enzymes, boosts H3K4 methylation, and suppresses MM1S cell growth.</p>Formula:C15H28Cl3N5O2Color and Shape:SolidMolecular weight:416.77LSD1-IN-19
<p>LSD1-IN-19 is a potent, selective LSD1 inhibitor with Ki of 0.108 μM and 72h IC50 values of 0.17-0.40 μM.</p>Formula:C33H42N6O2Color and Shape:SolidMolecular weight:554.73CFT8634
CAS:<p>CFT8634 degrades BRD9, for synovial sarcoma and SMARCB1 tumor research, from patent WO2021178920A1.</p>Formula:C37H45F3N6O5Color and Shape:SolidMolecular weight:710.79P300 bromodomain-IN-1
<p>P300 bromodomain-IN-1 blocks c-Myc, induces G1/G0 arrest, apoptosis. Potent EP300 inhibitor (IC50: 49 nM).</p>Formula:C29H31ClN4O4Color and Shape:SolidMolecular weight:535.03SCH-1473759
CAS:<p>SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).</p>Formula:C20H26N8OSPurity:98%Color and Shape:SolidMolecular weight:426.54QCA570
CAS:<p>QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).</p>Formula:C39H33N7O4SPurity:98%Color and Shape:SolidMolecular weight:695.79Londamocitinib
CAS:<p>Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.</p>Formula:C28H31F2N7O4SPurity:98.64% - 99.56%Color and Shape:SolidMolecular weight:599.65MAO A/HDAC-IN-1
<p>MAO A/HDAC-IN-1 is an effective monoamine oxidase A (MAO A) and HDAC dual inhibitor, which can be used for glioma research.</p>Formula:C21H24ClN3O3Color and Shape:SolidMolecular weight:401.89BRD4 D1-IN-2
<p>BRD4 D1-IN-2 (compound 26), a BRD4 D1 inhibitor, IC50 <0.092 μM, 15 nM affinity, >500x selectivity over BRD2 D1/BRD4 D2.</p>Formula:C33H39F3N6OColor and Shape:SolidMolecular weight:592.7
