Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2612 products of "Chromatin/Epigenetics"
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SAMS
CAS:SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).Formula:C74H131N29O18S2Purity:98%Color and Shape:SolidMolecular weight:1779.15PROTAC HDAC6 degrader 3
PROTACHDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader of HDAC6, with an IC50 of 686 nM and a DC50 of 171 nM. It enhances the acetylation of α-tubulin. [Pink: ligand for target protein; Blue: ligand for E3ligaseVHL.]Formula:C46H56F2N10O9SColor and Shape:SolidMolecular weight:963.06SIRT1/2/3-IN-1
CAS:Potent SIRT1/2/3-IN-1 inhibits SIRT1/2/3 with IC50: 0.54, 0.25, 0.72 μM; used in cancer research.Formula:C46H63N9O8S2Color and Shape:SolidMolecular weight:934.18JAK-STAT Compound Library
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;Color and Shape:Odour SolidRef: TM-L3700
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquirePROTAC BRD4 Degrader-5
CAS:PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.Formula:C50H62ClN9O8S2Color and Shape:SolidMolecular weight:1016.67SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Formula:C24H29ClN8O4SPurity:98.68%Color and Shape:SolidMolecular weight:561.06PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Formula:C50H58FN11O6SPurity:98%Color and Shape:SolidMolecular weight:960.13PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Formula:C55H60FN11O8SPurity:98%Color and Shape:SolidMolecular weight:1054.2KAT6-IN-2
KAT6-IN-2 is a potent inhibitor of KAT6, showing promise for use in cancer research.Color and Shape:Odour SolidHSP90/LSD1-IN-1
HSP90/LSD1-IN-1 (compound 6) is a dual inhibitor of HSP90 and LSD1. This compound effectively inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI50 values of 0.24 μM and 0.30 μM, respectively.Color and Shape:Odour SolidTB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Color and Shape:Odour SolidPim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Color and Shape:Odour SolidPRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Color and Shape:Odour SolidMT1
CAS:MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).Formula:C54H66Cl2N10O9S2Color and Shape:SolidMolecular weight:1134.2CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Color and Shape:SolidMNK/PIM-IN-1
CAS:MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.Formula:C27H27FN6O2Color and Shape:SolidMolecular weight:486.551CBP/p300-IN-8
CAS:CBP/p300-IN-8 strongly inhibits CBP/P300 bromodomains; CBP IC50=0.01-0.1μM, BRD4 IC50=1-1000μM.Formula:C27H31N3O4Color and Shape:SolidMolecular weight:461.562BRD4 degrader-6
CAS:BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.Formula:C61H71BClN9O7S2Color and Shape:SolidMolecular weight:1152.67BRD7-IN-1 free base
CAS:BRD7-IN-1, a BI7273 derivative, transforms into PROTAC VZ185 (targets BRD7/9 with 4.5/1.8 nM DC50s) via a VHL linker.Formula:C22H26N4O3Purity:98%Color and Shape:SolidMolecular weight:394.473β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS:3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.
Formula:C30H52O4Color and Shape:SolidMolecular weight:476.742
