Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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PROTAC BRD4 Degrader-13
CAS:<p>PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.</p>Formula:C68H85F2N11O17P2S2Color and Shape:SolidMolecular weight:1492.55PRO-HD1
<p>PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50</p>Purity:98%Color and Shape:Odour SolidPROTAC EED degrader-2
<p>PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.</p>Formula:C50H58FN11O6SPurity:98%Color and Shape:SolidMolecular weight:960.13TYD-68
<p>TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.</p>Color and Shape:Odour SolidBRD4 degrader AT1
CAS:<p>BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.</p>Formula:C48H58ClN9O5S3Purity:98%Color and Shape:SolidMolecular weight:972.68BAY-184
CAS:<p>BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.</p>Formula:C23H20N2O4SPurity:98.87%Color and Shape:SolidMolecular weight:420.48HDAC6-IN-56
<p>HDAC6-IN-56 (compound 18d) is an inhibitor of HDAC6, with an IC50 of 1.3 nM. This compound can inhibit the S phase and induce apoptosis in HCT-116 colon cancer cells.</p>Formula:C25H27ClN4O4SColor and Shape:SolidMolecular weight:514.14415PKC β pseudosubstrate
CAS:<p>Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).</p>Formula:C177H294N62O38S3Purity:98%Color and Shape:SolidMolecular weight:3994.84HDAC-IN-26
CAS:<p>HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.</p>Formula:C24H28FN5O3Color and Shape:SolidMolecular weight:453.518MS049 2HCl (1502816-23-0(free base))
<p>MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.</p>Formula:C15H26Cl2N2OPurity:99.9%Color and Shape:SolidMolecular weight:321.28Mersalyl
CAS:<p>Mersalyl is an organic mercurial diuretic.</p>Formula:C13H16HgNNaO6Color and Shape:SolidMolecular weight:505.854PROTAC BRD2/BRD4 degrader-1
<p>Compound 15: Potent PROTAC, selectively degrades BRD4/BRD2, has low toxicity, and is built of a BET inhibitor, linker, and CRBN ligand.</p>Formula:C39H38N6O9SPurity:98%Color and Shape:SolidMolecular weight:766.82PROTAC SMARCA2/4-degrader-26
<p>PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.</p>Formula:C38H47N9O5SColor and Shape:SolidMolecular weight:741.9(S,R,S)-AHPC-C5-COOH
CAS:<p>E3 ligase ligand-linker '(S,R,S)-AHPC-C5-COOH' for PROTACs, VH032 inhibits VHL/HIF-1α with 185 nM Kd, may aid anemia and ischemic disease research.</p>Formula:C29H42N4O5SPurity:98%Color and Shape:SolidMolecular weight:558.73PROTAC SMARCA2/4-degrader-27
CAS:<p>PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.</p>Formula:C49H58FN9O6SColor and Shape:SolidMolecular weight:920.11CBB1007 trihydrochloride (1379573-92-8 free base)
CAS:<p>CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).</p>Formula:C27H37Cl3N8O4Purity:98%Color and Shape:SoildMolecular weight:643.99SIRT1/2/3-IN-1
CAS:<p>Potent SIRT1/2/3-IN-1 inhibits SIRT1/2/3 with IC50: 0.54, 0.25, 0.72 μM; used in cancer research.</p>Formula:C46H63N9O8S2Color and Shape:SolidMolecular weight:934.18MZP-55
CAS:<p>MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)</p>Formula:C57H70ClN7O10SPurity:98%Color and Shape:SolidMolecular weight:1080.73JAK3-IN-15
<p>JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.</p>Color and Shape:Odour SolidGSK3735967
CAS:<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Formula:C25H31N7OSColor and Shape:SolidMolecular weight:477.62
