Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2612 products of "Chromatin/Epigenetics"
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PROTAC BRD2/BRD4 degrader-1
Compound 15: Potent PROTAC, selectively degrades BRD4/BRD2, has low toxicity, and is built of a BET inhibitor, linker, and CRBN ligand.Formula:C39H38N6O9SPurity:98%Color and Shape:SolidMolecular weight:766.82PKC β pseudosubstrate
CAS:Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).Formula:C177H294N62O38S3Purity:98%Color and Shape:SolidMolecular weight:3994.84SIM1
SIM1, a potent PROTAC®Degrader, preferentially degrades BET proteins (BRD4, BRD2, BRD3) and induces apoptosis in prostate cancer cells.Color and Shape:LiquidCW-3308
CW-3308 is an orally active PROTAC that targets BRD9. It is composed of the PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine. The coupling of the E3 ubiquitin ligase ligand with the linker results in the conjugate Thalidomide-pyrrolidine-C-azaspiro.Formula:C45H48N6O8Color and Shape:SolidMolecular weight:800.9PROTAC SMARCA2/4-degrader-26
PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.Formula:C38H47N9O5SColor and Shape:SolidMolecular weight:741.9Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS:Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.Formula:C56H110N22O14Purity:98%Color and Shape:SolidMolecular weight:1315.61SW2_110A acetate
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).Formula:C44H64N6O9Purity:98%Color and Shape:SoildMolecular weight:821.013β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS:3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.
Formula:C30H52O4Color and Shape:SolidMolecular weight:476.742ZIP
CAS:Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.Formula:C90H154N30O17Purity:98%Color and Shape:SolidMolecular weight:1928.4SAH-EZH2
CAS:EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.Formula:C155H256N48O40Purity:98%Color and Shape:SolidMolecular weight:3432.05PRMT5 ligand 1
CAS:PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.Formula:C20H26N6O2Color and Shape:SolidMolecular weight:382.459HDAC6 degrader-3
CAS:HDAC6 degrader-3: potent, selective, degrades HDAC6 at 19.4 nM, weakens HDAC1 at 0.647 μM, induces α-tubulin hyperacetylation.Formula:C41H41F4N7O11Color and Shape:SolidMolecular weight:883.8BRD4 degrader-6
CAS:BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.Formula:C61H71BClN9O7S2Color and Shape:SolidMolecular weight:1152.67BAY-184
CAS:BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.Formula:C23H20N2O4SPurity:98.87%Color and Shape:SolidMolecular weight:420.48N-Desmethyltamoxifen
CAS:N-Desmethyltamoxifen, tamoxifen's main human metabolite, regulates AML cell ceramide metabolism and is a more potent PKC inhibitor than tamoxifen.Formula:C25H27NOPurity:98%Color and Shape:SolidMolecular weight:357.49PRMT5-IN-12
CAS:PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formula:C32H40N4O4Color and Shape:SolidMolecular weight:544.696PRMT5-IN-9
CAS:PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.Formula:C25H23F3N6OColor and Shape:SolidMolecular weight:480.495PROTAC BRD4 Degrader-9
CAS:PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.Formula:C59H71F2N9O15S4Color and Shape:SolidMolecular weight:1312.5PROTAC SMARCA2/4 degrader-36
CAS:PROTACSMARCA2/4 degrader-36 (Compound 29) is a potent dual degrader targeting SMARCA2 and SMARCA4, exhibiting DC50 values of 0.22 nM and 0.85 nM, respectively. Additionally, PROTACSMARCA2/4 degrader-36 demonstrates antiproliferative activity.Formula:C53H62ClN9O4SColor and Shape:SolidMolecular weight:956.635R8-T198wt
CAS:Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.Formula:C111H211N59O26SPurity:98%Color and Shape:SolidMolecular weight:2820.33
