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Chromatin/Epigenetics

Chromatin/Epigenetics

Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.

Subcategories of "Chromatin/Epigenetics"

Found 2235 products of "Chromatin/Epigenetics"

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  • Thalidomide-NH-CBP/p300 ligand 2
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    Thalidomide-NH-CBP/p300 ligand 2

    CAS:
    <p>Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).</p>
    Formula:C48H57F2N11O6
    Color and Shape:Solid
    Molecular weight:922.052

    Ref: TM-T40142

  • Go6976
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    Go6976

    CAS:
    <p>Go6976 is a PKC inhibitor, widely used in research to probe PKC functions in health and disease.</p>
    Formula:C24H18N4O
    Purity:95.89%
    Color and Shape:Off-White To Yellow Solid
    Molecular weight:378.43

    Ref: TM-T6515

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    JAK3-IN-15

    <p>JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200631

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    Antidiabetic agent 7

    <p>Antidiabetic agent 7 (Compound 5m) functions as a potent hyperglycemia inhibitor. It effectively stimulates GLUT4 translocation in skeletal muscle cells by activating the AMPK-dependent pathway. Additionally, this compound is capable of reducing blood glucose levels and exhibits favorable pharmacokinetic properties. Antidiabetic agent 7 is suitable for research related to antihyperglycemic treatments.</p>
    Formula:C27H21Cl2N5O3
    Color and Shape:Solid
    Molecular weight:534.39

    Ref: TM-T205369

  • AUR1545
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    AUR1545

    CAS:
    <p>AUR1545 is a selective KAT2A/KAT2B degradator exhibiting inhibitory activity against cancer models including AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.</p>
    Formula:C41H50BrN9O5
    Purity:98.84%
    Color and Shape:Solid
    Molecular weight:828.8

    Ref: TM-T205224

  • BRD4 degrader-6
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    BRD4 degrader-6

    CAS:
    <p>BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.</p>
    Formula:C61H71BClN9O7S2
    Color and Shape:Solid
    Molecular weight:1152.67

    Ref: TM-T206915

  • mTOR/HDAC-IN-1
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    mTOR/HDAC-IN-1

    CAS:
    <p>mTOR/HDAC-IN-1, a dual inhibitor for mTOR &amp; HDAC1 with IC50s 0.49 &amp; 0.91 nM, potential anti-cancer agent.</p>
    Formula:C23H23N11O3
    Color and Shape:Solid
    Molecular weight:501.5

    Ref: TM-T63399

  • PROTAC SMARCA2/4 degrader-36
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    PROTAC SMARCA2/4 degrader-36

    CAS:
    <p>PROTACSMARCA2/4 degrader-36 (Compound 29) is a potent dual degrader targeting SMARCA2 and SMARCA4, exhibiting DC50 values of 0.22 nM and 0.85 nM, respectively. Additionally, PROTACSMARCA2/4 degrader-36 demonstrates antiproliferative activity.</p>
    Formula:C53H62ClN9O4S
    Color and Shape:Solid
    Molecular weight:956.635

    Ref: TM-T204281

  • JB300
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    JB300

    CAS:
    <p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>
    Formula:C43H45ClFN7O10S
    Color and Shape:Solid
    Molecular weight:906.375

    Ref: TM-T204223

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    PROTAC BRD4 Degrader-8

    <p>PROTAC BRD4 Degrader-8: BRD4 inhibitor with IC50s of 1.1/1.4 nM for BD1/BD2, degrades BRD4 in PC3 cells.</p>
    Color and Shape:Liquid

    Ref: TM-T36628

  • UNC4976
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    UNC4976

    <p>UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.</p>
    Formula:C47H70N6O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:847.09

    Ref: TM-T13255

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    Eldocasiran

    CAS:
    <p>Eldocasiran, a micro-RNA-193a-3p analogue, exhibits anticancer properties. It is utilized in cancer research [1].</p>
    Formula:C423H529N161O305P42
    Color and Shape:Solid
    Molecular weight:14049.5

    Ref: TM-T74574

  • SIRT1-IN-1
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    SIRT1-IN-1

    CAS:
    <p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>
    Formula:C14H16N2O
    Purity:99.58%
    Color and Shape:Solid
    Molecular weight:228.29

    Ref: TM-T9648

  • GSK3735967
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    GSK3735967

    CAS:
    <p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>
    Formula:C25H31N7OS
    Color and Shape:Solid
    Molecular weight:477.62

    Ref: TM-T74887

  • FKBP12 PROTAC dTAG-7
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    FKBP12 PROTAC dTAG-7

    CAS:
    <p>dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.</p>
    Formula:C63H79N5O19
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1210.32

    Ref: TM-T11292

  • Myelin Basic Protein
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    Myelin Basic Protein

    CAS:
    <p>Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.</p>
    Formula:C60H103N21O17
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1390.59

    Ref: TM-TP1650

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    CB1R/AMPK modulator 1

    <p>Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R.</p>
    Formula:C25H22Cl2N6O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:557.45

    Ref: TM-T79649

  • MAK-683 hydrochloride
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    MAK-683 hydrochloride

    CAS:
    <p>MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.</p>
    Formula:C20H18ClFN6O
    Purity:97.02% - >99.99%
    Color and Shape:Solid
    Molecular weight:412.85

    Ref: TM-T9681

  • GSK9311 hydrochloride
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    GSK9311 hydrochloride

    CAS:
    <p>GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).</p>
    Formula:C24H32ClN5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:474

    Ref: TM-T13715

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    HDAC1-IN-9

    <p>HDAC1-IN-9 (13c) is an HDAC1 inhibitor. It inhibits the HDAC1 enzyme with an IC50 value of 1.07 µM. This compound exhibits the strongest antiproliferative activity against HT-29 (human colon adenocarcinoma cells), with an IC50 of 1.78 μM. In HCT-116 (human colon cancer cells), HDAC1-IN-9 significantly induces apoptosis. Additionally, HDAC1-IN-9 possesses antiangiogenic properties, reducing the expression levels of VEGFR-2 and phosphorylated VEGFR-2 (pVEGFR-2) by approximately 80%.</p>
    Formula:C17H17N3O3
    Color and Shape:Solid
    Molecular weight:311.34

    Ref: TM-T205384