Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2612 products of "Chromatin/Epigenetics"
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Thalidomide-NH-CBP/p300 ligand 2
CAS:Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).Formula:C48H57F2N11O6Color and Shape:SolidMolecular weight:922.052PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8: BRD4 inhibitor with IC50s of 1.1/1.4 nM for BD1/BD2, degrades BRD4 in PC3 cells.Color and Shape:LiquidUNC10142
UNC10142 (Compound 44) is a small-molecule antagonist of CHD1, with a binding IC50 value of 1.7 μM. It induces a dose-dependent reduction in the viability of PTEN-deficient prostate cancer cells.Formula:C33H52N6O3Color and Shape:SolidMolecular weight:580.8Eldocasiran
CAS:Eldocasiran, a micro-RNA-193a-3p analogue, exhibits anticancer properties. It is utilized in cancer research [1].Formula:C423H529N161O305P42Color and Shape:SolidMolecular weight:14049.5SIRT1-IN-1
CAS:SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Formula:C14H16N2OPurity:99.58%Color and Shape:SolidMolecular weight:228.29Ref: TM-T9648
1mg92.00€5mg192.00€10mg295.00€25mg505.00€50mg708.00€100mg964.00€200mg1,288.00€1mL*10mM (DMSO)195.00€XF067-68
CAS:XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Formula:C52H59F4N9O7SColor and Shape:SolidMolecular weight:1030.14AUR1545
CAS:AUR1545 is a selective KAT2A/KAT2B degradator, inhibitory against AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.Formula:C41H50BrN9O5Purity:98.84%Color and Shape:SolidMolecular weight:828.8KB02-JQ1
CAS:KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.Formula:C38H43Cl2N7O6SPurity:98%Color and Shape:SoildMolecular weight:796.77CB1R/AMPK modulator 1
Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R.Formula:C25H22Cl2N6O3SPurity:98%Color and Shape:SolidMolecular weight:557.45SR-0813
CAS:SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9.Formula:C25H32N6O3SPurity:98.81%Color and Shape:SolidMolecular weight:496.62Ref: TM-T40229
1mg39.00€5mg86.00€10mg124.00€25mg253.00€50mg384.00€100mg532.00€200mg705.00€1mL*10mM (DMSO)94.00€[Ala107]MBP(104-118)
CAS:Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).Formula:C67H104N20O19Purity:98%Color and Shape:SolidMolecular weight:1493.68PROTAC_ERRα
CAS:PROTAC_ERRα is a potent, selective degrader of ERRα, efficiently facilitating its proteasomal degradation.Formula:C46H47F3N6O9S2Color and Shape:SolidMolecular weight:949.03CBB1007 trihydrochloride (1379573-92-8 free base)
CAS:CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Formula:C27H37Cl3N8O4Purity:98%Color and Shape:SoildMolecular weight:644.0Ref: TM-T10699L2
2mg131.00€5mg187.00€10mg283.00€50mg665.00€100mg1,034.00€200mgTo inquire500mgTo inquire1mL*10mM (DMSO)264.00€PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Formula:C55H60FN11O8SPurity:98%Color and Shape:SolidMolecular weight:1054.2GNE-987
CAS:GNE-987 is a potent chimeric BET degrader, binding BRD4 BD1/BD2 at IC50: 4.7/4.4 nM & has a DC50: 0.03 nM in EOL-1 AML cells.Formula:C56H67F2N9O8S2Purity:98%Color and Shape:SolidMolecular weight:1096.31dBAZ2
dBAZ2 is a pioneering PROTAC degrader targeting BAZ2A and BAZ2B, with DC50 values of 180 nM for BAZ2A and 250 nM for BAZ2B.Formula:C54H64FN11O5S2Color and Shape:SolidMolecular weight:1030.29TDI-012804
TDI-012804 is a TNKS2 inhibitor that selectively inhibits endogenous TNKS2 protein within cells. It enhances the expression of AXIN1 protein in Tnks1 heterozygous (Tnks1HET) and knockout (Tnks1KO) cells. TDI-012804 suppresses the proliferation of ApcQ1405X/Tnks1KO organoids with an EC50 of 59.1 nM and exhibits selective toxicity towards Tnks1KO AKP-G12D and AKP-G13D organoids.Color and Shape:Odour SolidEXQ-2d
EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.Formula:C18H17N3O3Color and Shape:SolidMolecular weight:323.35HAT-SIL-TG-1&AT
HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.Formula:C60H69N17O11SColor and Shape:SolidMolecular weight:1236.36HDAC-IN-26
CAS:HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.Formula:C24H28FN5O3Color and Shape:SolidMolecular weight:453.518
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