Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2612 products of "Chromatin/Epigenetics"
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SGC3027
SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.Formula:C41H47ClN6O6SPurity:98%Color and Shape:SolidMolecular weight:787.37Y16526
Y16526 is a potent inhibitor of the CBP/p300 bromodomain (CBP/p300bromodomain) with an IC50 of 0.03 μM. Y16524 shows potential for research in acute myeloid leukemia (AML).Formula:C30H34FN5O4Color and Shape:SolidMolecular weight:547.62BRCA1-IN-1
CAS:BRCA1-IN-1 is a novel small-molecule-like inhibitor of BRCA1 (IC50: 0.53 μM; Ki: 0.71 μM).Formula:C27H33F2N4O6PPurity:98%Color and Shape:SolidMolecular weight:578.54DAO-dBET1
DAO-dBET1, a dual-action PROTAC incorporating the PROTAC degrader dBET1, effectively serves as a potent BRD4 degrader and exhibits a DC50 value of 277 nM in the presence of CoCl2. Additionally, DAO-dBET1 inhibits hypoxia and Cath-L activation with an IC50 value of 281 nM.Color and Shape:Odour Solid(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS:(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.Formula:C41H46N6O6SColor and Shape:SolidMolecular weight:750.91HDAC6 degrader-3
CAS:HDAC6 degrader-3: potent, selective, degrades HDAC6 at 19.4 nM, weakens HDAC1 at 0.647 μM, induces α-tubulin hyperacetylation.Formula:C41H41F4N7O11Color and Shape:SolidMolecular weight:883.8BRD4 degrader-6
CAS:BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.Formula:C61H71BClN9O7S2Color and Shape:SolidMolecular weight:1152.67SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formula:C41H46N12O5SColor and Shape:SolidMolecular weight:818.95Ep300/CREBBP-IN-4
CAS:Ep300/CREBBP-IN-4, an Ep300 & CREBBP inhibitor; IC50: 0.024μM & 0.064μM. For cancer research.Formula:C23H22F3N5O3Color and Shape:SolidMolecular weight:473.45HSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Purity:98%Color and Shape:Odour SolidHDAC-IN-68 hydrochloride
HDAC-IN-68 (hydrochloride) (Compound 29) is an HDACs inhibitor with an IC50 value of 0.04 μM and induces microtubule fragmentation by activating katanin, a microtubule-severing protein. It is applicable in cancer research.Formula:C27H25ClN8O6Molecular weight:592.15856SARS-CoV-2-IN-87
SARS-CoV-2-IN-87 (compound 138968421) is an effective inhibitor of the SARS-CoV-2 methyltransferases (nsp14 and nsp16).Formula:C26H40O6Molecular weight:448.28249MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Color and Shape:Odour SolidMalantide TFA
Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.Formula:C74H125F3N22O23Color and Shape:SolidMolecular weight:1747.91PRMT5-IN-9
CAS:PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.Formula:C25H23F3N6OColor and Shape:SolidMolecular weight:480.4953',4'-Dimethoxyflavone
CAS:3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities.Formula:C17H14O4Purity:98.05%Color and Shape:SolidMolecular weight:282.29MARK4 inhibitor 2
MARK4 Inhibitor 2 is a potent inhibitor of Microtubule Affinity-Regulating Kinase 4 (MARK4), exhibiting a Kₘ of 6.3×10⁷ and an IC₅₀ of 0.82 μM.Formula:C34H30N4O3Purity:98%Color and Shape:SolidMolecular weight:542.63PROTAC HDAC6 degrader 6
PROTACHDAC6 degrader 6 (Compound 12) is a selective photochemical targeting chimera (PHOTACs), a subset of PROTACs, designed to target HDAC6. Its activity is specifically activated to its cis-state upon irradiation with 390 nm light, resulting in a degradation maximum (Dmax) of approximately 50%.Color and Shape:Odour SolidFluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Color and Shape:SolidPROTAC SMARCA2/4-degrader-28
CAS:PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.Formula:C54H68ClN9O11S2Color and Shape:SolidMolecular weight:1118.75
