Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2612 products of "Chromatin/Epigenetics"
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INCB059872
CAS:INCB059872: potent, oral, selective LSD1 inhibitor for myeloid leukemia research.Formula:C23H34N2O3Color and Shape:SolidMolecular weight:386.536PROTAC BET degrader-2
CAS:PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).Formula:C41H42N10O6Purity:98%Color and Shape:SolidMolecular weight:770.84HDAC-IN-80
HDAC-IN-80 (compound 5) is a selective inhibitor of class I HDAC.Color and Shape:Odour SolidDot1L-IN-1 TFA
Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).Formula:C34H37ClF3N9O4SColor and Shape:SolidMolecular weight:760.23PROTAC TYK2 degrader-1
CAS:PROTAC TYK2 degrader-1 (CPD-155) functions as a selective degrader of TYK2, demonstrating a degradation maximum (D max) greater than 60%. This compound effectively targets TYK2 for degradation, utilizing a linker to connect the TYK2 ligand with the VHL ligand Thalidomide, each color-coded for identification.Formula:C40H41N13O7Molecular weight:815.84EZH2-IN-19
CAS:EZH2-IN-19 (compound N40) is a potent inhibitor of the wild-type enhancer of zeste homolog 2 (EZH2), with an IC50 of 0.32 nM. It plays a significant role in cancer research.Formula:C40H55N7O3Molecular weight:681.91RK 286D
CAS:RK 286D is an indolocarbazole antibiotic.Formula:C26H23N3O4Color and Shape:SolidMolecular weight:441.48Menin-KMT2A-IN-1
Menin–KMT2A-IN-1 (Compound 20) is an inhibitor of menin–KMT2A, binding to menin with an IC50 of 8 nM, and disrupting the interaction between menin and lysine methyltransferase 2A (KMT2A). It inhibits hERG channels with an IC50 of 65 μM and suppresses MV4-11 cells with an IC50 of 74 nM. Furthermore, Menin–KMT2A-IN-1 exhibits favorable pharmacokinetic properties in CD-1 mice, with an oral bioavailability of 74%.Formula:C28H35FN6O3Color and Shape:SolidMolecular weight:522.61Fibrostatin C
CAS:Fibrostatin C is an inhibitor of prolyl 4-hydroxylase. It is produced by Streptomyces catenulae subsp.Formula:C18H19NO8SColor and Shape:SolidMolecular weight:409.41PROTAC MPS1 degrader 1
PROTAC MPS1 degrader 1 (Compound 19) acts as a potent degrader of Monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB, with DC50 values of 17.7, 108.7, and 570.3 nM respectively. It is utilized in the study of acute myeloid leukemia. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase)Formula:C41H46N12O7Color and Shape:SolidMolecular weight:818.88mUNO
CAS:mUNO is a tumor-homing peptide (mUNO, sequence: "CSPGAK") that specifically binds to murine CD206, targeting tumor-associated macrophages that express CD206/MRC1. Additionally, mUNO can interact with human recombinant CD206.Formula:C22H39N7O8SColor and Shape:SolidMolecular weight:561.652PROTAC SMARCA2 degrader-26
CAS:PROTAC SMARCA2 degrader-26 (compound 45) is an effective degrader of SMARCA2 using the PROTAC technology. It induces degradation of SMARCA2 and SMARCA4 in VCaP cells, with degradation percentages of 94% and 57%, respectively. Additionally, PROTAC SMARCA2 degrader-26 demonstrates antiproliferative activity.Formula:C46H54N8O5SColor and Shape:SolidMolecular weight:831.04UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.Formula:C47H70N6O8Purity:98%Color and Shape:SolidMolecular weight:847.09TYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.Formula:C23H21FN4O2Color and Shape:SolidMolecular weight:404.16485HDAC/CD13-IN-1
HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μMFormula:C27H41Cl2N5O4Purity:98%Color and Shape:SolidMolecular weight:570.55PRMT5-IN-4
CAS:PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.Formula:C11H13N3O4SColor and Shape:SolidMolecular weight:283.3Izilendustat
CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Formula:C22H28ClN3O4Purity:99.95%Color and Shape:SolidMolecular weight:433.93Ref: TM-T64336
5mg43.00€10mg60.00€25mg103.00€50mg166.00€100mg259.00€200mg378.00€1mL*10mM (DMSO)47.00€Cath-L-dBET1
Cath-L-dBET1 is a PROTAC degrader targeting BRD4. It has an IC50 value of 2.8 μM in MDA-MB-231 cells. Activated by cathepsin L (Cath-L), Cath-L-dBET1 recruits E3 ubiquitin ligase to degrade BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable for antitumor research.Color and Shape:Odour Solid(rel)-Tranylcypromine D5 hydrochloride
CAS:(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride.Formula:C9H12ClNPurity:98%Color and Shape:SolidMolecular weight:174.682Tubulin/HDAC-IN-3
Tubulin/HDAC-IN-3 (compound 12a) serves as a potent dual inhibitor of tubulin polymerization and HDAC1/8, exhibiting IC50 values of 5.4 μM for tubulinFormula:C28H28N2O10Color and Shape:SolidMolecular weight:552.53
