Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2613 products of "Chromatin/Epigenetics"
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POI ligand 1
POI ligand 1 serves as a template for the non-selective HDAC inhibitor Vorinostat. It functions as a target protein ligand (PROTAC target protein ligand) in the creation of PROTAC HDAC degraders with anti-tumor properties. Additionally, POI ligand 1 is utilized in the synthesis of FF2049.Formula:C14H21N3O3Color and Shape:SolidMolecular weight:279.335SJ1008030
CAS:SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.
Formula:C42H43N13O7SColor and Shape:SolidMolecular weight:873.94Retreversine
CAS:Retreversine serves as an inactive control counterpart to Reversine, a pioneering class of ATP-competitive Aurora kinase inhibitor.Formula:C21H27N7OColor and Shape:SolidMolecular weight:393.49Malantide
CAS:Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Formula:C72H124N22O21Purity:98%Color and Shape:SolidMolecular weight:1633.89HDAC-IN-26
CAS:HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.Formula:C24H28FN5O3Color and Shape:SolidMolecular weight:453.518Pep2m, myristoylated
CAS:Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Formula:C63H118N18O14SPurity:98%Color and Shape:SolidMolecular weight:1383.8PROTAC SMARCA2/4-degrader-26
PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.Formula:C38H47N9O5SColor and Shape:SolidMolecular weight:741.9Axltide
CAS:Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Formula:C63H107N19O20S2Purity:98%Color and Shape:SolidMolecular weight:1514.77MZP-55
CAS:MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)Formula:C57H70ClN7O10SPurity:98%Color and Shape:SolidMolecular weight:1080.73SGC3027
SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.Formula:C41H47ClN6O6SPurity:98%Color and Shape:SolidMolecular weight:787.37PROTAC SMARCA2/4-degrader-27
CAS:PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.Formula:C49H58FN9O6SColor and Shape:SolidMolecular weight:920.11RJW100
CAS:RJW100 is a potent LRH-1 & SF-1 agonist with pEC50 of 6.6 & 7.5, also activates miR-200c promoter.Formula:C28H34OPurity:99.45%Color and Shape:SolidMolecular weight:386.57Dot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Color and Shape:Odour SolidIzilendustat
CAS:Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Formula:C22H28ClN3O4Purity:99.95%Color and Shape:SolidMolecular weight:433.93Ref: TM-T64336
5mg43.00€10mg60.00€25mg103.00€50mg166.00€100mg259.00€200mg378.00€1mL*10mM (DMSO)47.00€PRMT5 ligand 1
CAS:PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.Formula:C20H26N6O2Color and Shape:SolidMolecular weight:382.459Biotinylated-JQ1
CAS:Biotin-JQ1 is a bromodomain BRD4 binder; inhibits MM1.S cell growth with EC50 of 0.4μM.Formula:C39H53ClN8O6S2Color and Shape:SolidMolecular weight:829.47ML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Color and Shape:Odour SolidCath-L-dBET1
Cath-L-dBET1 is a PROTAC degrader targeting BRD4. It has an IC50 value of 2.8 μM in MDA-MB-231 cells. Activated by cathepsin L (Cath-L), Cath-L-dBET1 recruits E3 ubiquitin ligase to degrade BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable for antitumor research.Color and Shape:Odour SolidAURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Formula:C28H32FN9O2Color and Shape:SolidMolecular weight:545.61(rel)-Tranylcypromine D5 hydrochloride
CAS:(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride.Formula:C9H12ClNPurity:98%Color and Shape:SolidMolecular weight:174.682SIRT1/2/3-IN-1
CAS:Potent SIRT1/2/3-IN-1 inhibits SIRT1/2/3 with IC50: 0.54, 0.25, 0.72 μM; used in cancer research.Formula:C46H63N9O8S2Color and Shape:SolidMolecular weight:934.18PROTAC SMARCA2/4-degrader-31
CAS:PROTAC SMARCA2/4-degrader-31 (Compound I-280) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in A549 cells and SMARCA4 in MV411 cells, both with a degradation concentration (DC50) of less than 100 nM.Formula:C44H51N11O4Color and Shape:SolidMolecular weight:797.95Neuropeptide DF2
CAS:Neuropeptide DF2 is an FMRFamide-related neuropeptide from crayfish.Formula:C44H67N15O10Purity:98%Color and Shape:SolidMolecular weight:966.1MS2133
MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.Formula:C58H66ClF3N14O11S2Color and Shape:SolidMolecular weight:1290.41175DAO-dBET1
DAO-dBET1, a dual-action PROTAC incorporating the PROTAC degrader dBET1, effectively serves as a potent BRD4 degrader and exhibits a DC50 value of 277 nM in the presence of CoCl2. Additionally, DAO-dBET1 inhibits hypoxia and Cath-L activation with an IC50 value of 281 nM.Color and Shape:Odour SolidNF-κB/HIF-1α-IN-1
NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.Formula:C24H27N7O4Color and Shape:SolidMolecular weight:477.21245ZINC000014708529
ZINC000014708529 is a potent SIRT7 inhibitor exhibiting high affinity for SIRT7 and is utilized in cancer research [1].Color and Shape:Odour SolidPROTAC MPS1 degrader 2
PROTAC MPS1 Degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB with DC50 values of 42.0, 2.1, and 154.0 nM respectively. It is utilized in the research of acute myeloid leukemia.Formula:C41H41N11O8SColor and Shape:SolidMolecular weight:847.90PROTAC MPS1 degrader 1
PROTAC MPS1 degrader 1 (Compound 19) acts as a potent degrader of Monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB, with DC50 values of 17.7, 108.7, and 570.3 nM respectively. It is utilized in the study of acute myeloid leukemia. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase)Formula:C41H46N12O7Color and Shape:SolidMolecular weight:818.88E67-2
CAS:E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Formula:C21H36N6O2Color and Shape:SolidMolecular weight:404.559PROTAC BRD4-binding moiety 1
CAS:BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.Formula:C23H21N3O2Purity:98%Color and Shape:SolidMolecular weight:371.43OKI-006
CAS:OKI-006 is an oral HDAC inhibitor with potential for cancer research, derived from largazole.Formula:C21H30N4O5S2Color and Shape:SolidMolecular weight:482.62(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS:(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.Formula:C41H46N6O6SColor and Shape:SolidMolecular weight:750.91KDM4 ligand-1
KDM4ligand-1 is a ligand targeting the protein (histone lysine demethylase KDM4) in PROTACs. It can be utilized for the synthesis of PROTACs.Color and Shape:Odour SolidHSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Purity:98%Color and Shape:Odour SolidPROTAC SMARCA2/4-degrader-30
CAS:Compound I-291, also known as PROTAC SMARCA2/4-degrader-30, targets the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.Formula:C44H51N11O4Color and Shape:SolidMolecular weight:797.95(+)-JQ-1-aldehyde
(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].Color and Shape:SolidZSNI-21
ZSNI-21 is a dual inhibitor targeting ADAM17 and HDAC2. It effectively suppresses the proliferation of Bel-7402 cells and exhibits significant anti-metastatic properties against HCC-LM3 cells, making it a promising candidate for hepatocellular carcinoma (HCC) research.Formula:C26H25N3O5Color and Shape:SolidMolecular weight:459.49Delcasertib acetate
Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.Formula:C122H203N45O36S2Purity:98.92%Color and Shape:SolidMolecular weight:2940.33Ref: TM-T11740L
1mg166.00€2mg213.00€5mg313.00€10mg442.00€25mg642.00€50mg880.00€100mg1,179.00€200mg1,594.00€Nicotinamide riboside tartrate
CAS:NRT is an oral NAD+ precursor, boosts NAD+, activates SIRT1/3, provides vitamin B3, enhances metabolism, and may mitigate Alzheimer's.Formula:C15H20N2O11Color and Shape:SolidMolecular weight:404.33dBET23
CAS:dBET23 is a BRD4 degrader.Formula:C43H45ClN8O9SColor and Shape:SolidMolecular weight:885.38EP300/CBP ligand 2
EP300/CBP ligand 2 (compound S19) serves as a specific ligand for the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). It plays a critical role in PROTAC technology by acting as a target protein ligand. By linking to an E3 ubiquitin ligase ligand via the PROTAC Linker, it facilitates the synthesis of PROTAC molecules capable of targeted protein degradation. For instance, when EP300/CBP ligand 2 is connected to the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc, it results in the formation of the PROTAC molecule dCE-2.Formula:C20H18N6OColor and Shape:SolidMolecular weight:358.4EPZ-719
CAS:EPZ-719 is a selective and orally available SETD2 inhibitor (IC50 = 0.005 μM), with anti-cancer activity, and can be used for hematological malignancies.Formula:C22H31FN4O3SPurity:99.95%Color and Shape:SolidMolecular weight:450.57Ref: TM-T40318
1mg177.00€5mg385.00€10mg618.00€25mg1,305.00€50mg2,088.00€100mg5,670.00€1mL*10mM (DMSO)383.00€PRMT1-IN-1
CAS:PRMT1-IN-1 is a PRMT1 inhibitor.
Formula:C20H7Br6NO5Color and Shape:SolidMolecular weight:820.702MRTX9768 hydrochloride
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.Color and Shape:SolidHDAC11-IN-1
HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.Formula:C43H63F3N6O6S2Color and Shape:SolidMolecular weight:881.12ACBI2
CAS:ACBI2: potent, oral VHL PROTAC, EC50=7nM; degrades SMARCA2, DC50=1nM in RKO cells; for lung cancer research.Formula:C56H68BrFN8O5SColor and Shape:SolidMolecular weight:1064.16CARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Formula:C27H35ClN6O3Color and Shape:SolidMolecular weight:527.06α-Hydroxyglutaric Acid
CAS:α-Hydroxyglutaric Acid is a natural product for research related to life sciences. The catalog number is T36624 and the CAS number is 2889-31-8.Formula:C5H8O5Color and Shape:SolidMolecular weight:148.114
