Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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JAK3-IN-9
CAS:<p>JAK3-IN-9, potent JAK3 inhibitor, IC50 of 1.7 nM, highly selective, low toxicity, orally bioavailable, shows anti-arthritis activity.</p>Formula:C17H23N5O4SColor and Shape:SolidMolecular weight:393.46PARP-2/1-IN-2
CAS:<p>PARP-2/1-IN-2, Veliparib's enantiomer, inhibits PARP-1/2 (Ki: 5/2 nM) with 3 nM EC50 in cell assay.</p>Formula:C13H16N4OColor and Shape:SolidMolecular weight:244.29ZLD10A
CAS:<p>ZLD10A is a highly potent and selective small molecule inhibitor of EZH2.</p>Formula:C37H48N4O4Purity:98%Color and Shape:SolidMolecular weight:612.8WAY-260022
CAS:<p>WAY-260022 is the norepinephrine transporter inhibitor.</p>Formula:C21H31F3N2O2Purity:97.61% - 99.41%Color and Shape:SolidMolecular weight:400.48LB-205
CAS:<p>LB-205 is a Zn 2+ dependent pan-inhibitor of class I and class II HDACs. It also has a long half-life in vivo.</p>Formula:C18H21N3O2SColor and Shape:SolidMolecular weight:343.44CBP/p300-IN-10
CAS:<p>CBP/p300-IN-10, potent EP300/CREBBP inhibitor; IC50: 26 nM/39 nM. Potential for cancer research.</p>Formula:C25H24F5N5O3Color and Shape:SolidMolecular weight:537.48INCB16562
CAS:<p>INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.</p>Formula:C19H11Cl2N5Color and Shape:SolidMolecular weight:380.23Guadecitabine
CAS:<p>Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.</p>Formula:C18H24N9O10PPurity:98%Color and Shape:SolidMolecular weight:557.41Aurora A/PKC-IN-1
CAS:<p>Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.</p>Formula:C16H14N6OSe2Color and Shape:SolidMolecular weight:464.24PRMT5-IN-10
CAS:<p>PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.</p>Formula:C13H17N5O4Color and Shape:SolidMolecular weight:307.31DDO-2093 dihydrochloride
<p>DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.</p>Formula:C29H39Cl3FN9O3Color and Shape:SolidMolecular weight:687.04Depudecin
CAS:<p>Depudecin, a polyketide from Alternaria brassicicola, has an 11-carbon chain with two epoxides and six stereocenters, inhibits HDAC, and is anti-angiogenic.</p>Formula:C11H16O4Color and Shape:SolidMolecular weight:212.24UNC0379 TFA
CAS:<p>UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.</p>Formula:C25H36F3N5O4Color and Shape:SolidMolecular weight:527.589Bromodomain inhibitor-8
CAS:<p>Bromodomain inhibitor-8 is an inhibitor of BET bromodomain used to treat autoimmune and inflammatory diseases.</p>Formula:C26H25ClN2O3Color and Shape:SolidMolecular weight:448.94F-amidine
CAS:<p>F-amidine is a bioavailable irreversible PAD4 inactivator.</p>Formula:C14H19FN4O2Color and Shape:SolidMolecular weight:294.32JNJ-9350
CAS:<p>JNJ-9350: SMOX inhibitor (IC50 0.01 μM), PAO inhibitor (IC50 0.79 μM), for cancer research.</p>Formula:C25H22N6OColor and Shape:SolidMolecular weight:422.48CPI-455 HCl
CAS:<p>CPI-455: specific KDM5A inhibitor, IC50=10±1nM, increases H3K4me3, reduces DTPs in cancer cells.</p>Formula:C16H15ClN4OPurity:98%Color and Shape:SolidMolecular weight:314.77ZL0454
CAS:<p>ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).</p>Formula:C18H22N4O3SPurity:98%Color and Shape:SolidMolecular weight:374.46S2101
CAS:<p>S2101 is a specific LSD1 histone demethylase inhibitor with an IC50 of 0.99 μM and a Ki of 0.61 μM, suitable for research into cancer and viral infections.</p>Formula:C16H16ClF2NOPurity:98%Color and Shape:SolidMolecular weight:311.75LEM-14-1189
CAS:<p>LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood diseases.</p>Formula:C35H34N6O5S2Purity:98.06%Color and Shape:SolidMolecular weight:682.81BRD4-BD1-IN-2
CAS:<p>BRD4-BD1-IN-2: Potent, selective BRD4-BD1 inhibitor, IC50=2.51µM; 20x less active on BD2; for cardiovascular/cancer research.</p>Formula:C20H15Br3N4O2Purity:99.39%Color and Shape:SolidMolecular weight:583.07PI3K/HDAC-IN-1
CAS:<p>PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).</p>Formula:C22H25FN4O4Purity:98%Color and Shape:SolidMolecular weight:428.46MAT2A-IN-4
CAS:<p>MAT2A-IN-4 can be used for the cancer research that is an inhibitor of methionine adenosyltransferase 2A (MAT2A)[1].</p>Formula:C18H16ClN3OColor and Shape:SolidMolecular weight:325.79SIRT5 inhibitor 2
CAS:<p>SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.</p>Formula:C18H12Cl2N2O3SPurity:99.38% - 99.87%Color and Shape:SolidMolecular weight:407.27MC4343
<p>MC4343, a potent dual inhibitor targeting both EZH2 and histone deacetylase, presents promising potential for cancer research applications.</p>Formula:C36H41N5O4Color and Shape:SolidMolecular weight:607.74Furamidine dihydrochloride
CAS:<p>Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.</p>Formula:C18H18Cl2N4OPurity:98.16%Color and Shape:SolidMolecular weight:377.27KD 5170
CAS:<p>KD 5170, a pan inhibitor of histone deacetylases (HDACs), demonstrates widespread antitumor activity both in vitro and in vivo [1].</p>Formula:C20H25N3O5S2Color and Shape:SolidMolecular weight:451.561,2,3,4,5,6-Hexabromocyclohexane
CAS:<p>Inhibits JAK2 autophosphorylation; non-cytotoxic at 100μM; 1μM reduces activity by 50%, 50μM nearly abolishes it.</p>Formula:C6H6Br6Purity:98%Color and Shape:SolidMolecular weight:557.54Bromodomain inhibitor-9
CAS:<p>Bromodomain inhibitor-9 selectively targets BRD4-1 (Kd 12 nM), used in metabolic, inflammatory, fibrotic, and autoimmune disease studies.</p>Formula:C24H28N4O5SColor and Shape:SolidMolecular weight:484.57SYK/JAK-IN-1
CAS:<p>SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.</p>Formula:C24H26N8O3Color and Shape:SolidMolecular weight:474.52Tankyrase-IN-2
CAS:<p>Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively</p>Formula:C17H14F2N2O2Purity:98%Color and Shape:SolidMolecular weight:316.3NSC-311068
CAS:<p>NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.</p>Formula:C10H6N4O4SColor and Shape:SolidMolecular weight:278.24GNE-272
CAS:<p>GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.</p>Formula:C22H25FN6O2Color and Shape:SolidMolecular weight:424.47SD-1029
CAS:<p>SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.</p>Formula:C25H32Br2Cl2N2O3Color and Shape:SolidMolecular weight:639.256(5H)-Phenanthridinone
CAS:<p>6(5H)-Phenanthridinone suppresses PARP1/2, reduces RDM4 cell growth, downregulates pro-inflammatory genes, and alleviates EAE symptoms in rats.</p>Formula:C13H9NOColor and Shape:SolidMolecular weight:195.22NCC-149
CAS:<p>NCC-149 is a HDAC8 inhibitor.</p>Formula:C16H14N4O2SColor and Shape:SolidMolecular weight:326.37MS-1020
CAS:<p>MS-1020 inhibits JAK3/STAT3, blocks active JAK3, suppresses JAK3/STAT5 signaling, and targets STAT3 in certain cells.</p>Formula:C21H18N2O3Purity:98%Color and Shape:SolidMolecular weight:346.38AC-93253 iodide
CAS:<p>AC-93253 iodide is a selective inhibitor of SIRT2. It significantly enhances the acetylation of tubulin p53 and histone H4.</p>Formula:C23H25IN2SPurity:98%Color and Shape:SolidMolecular weight:488.43Jaspamycin
CAS:<p>Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.</p>Formula:C12H12N4O5Color and Shape:SolidMolecular weight:292.25Ac-Lys-AMC
CAS:<p>Ac-Lys-AMC (Hexanamide) is a fluorescent substrate for histone deacetylase HDACs.</p>Formula:C18H23N3O4Purity:98%Color and Shape:SolidMolecular weight:345.39(R)-UT-155
CAS:<p>(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.</p>Formula:C20H15F4N3O2Color and Shape:SolidMolecular weight:405.35ZYJ-34v
CAS:<p>ZYJ-34v is an oral histone deacetylase inhibitor (HDACi) with potent antitumor activities.</p>Formula:C27H35N3O6Purity:98%Color and Shape:SolidMolecular weight:497.58TUL01101
CAS:<p>TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.</p>Formula:C22H25F2N5O2Color and Shape:SolidMolecular weight:429.46ARTD10/PARP10-IN-1
CAS:<p>ARTD10/PARP10-IN-1 is a PARP inhibitor that inhibits ARTD8/PARP14 and has anticancer and antitumour activity for the study of prostate cancer.</p>Formula:C12H12N2O4Purity:99.14%Color and Shape:SolidMolecular weight:248.23BPTF-IN-1
CAS:<p>BPTF-IN-1 (AU1), a BPTF bromodomain inhibitor with 2.8 μM affinity, shows higher selectivity over BRD4 and possesses antimalarial properties.</p>Formula:C23H23FN6O3Color and Shape:SolidMolecular weight:450.47CPI-4203
CAS:<p>CPI-4203 is a selective inhibitor of KDM5 demethylases.</p>Formula:C16H14N4OColor and Shape:SolidMolecular weight:278.31LSD1-IN-13
CAS:<p>LSD1-IN-13, an oral LSD1 blocker (IC50: 24.43 nM), boosts CD86 (EC50: 470 nM), and triggers AML cell line differentiation.</p>Formula:C23H29N3O2SColor and Shape:SolidMolecular weight:411.56BI-9321
CAS:<p>BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.</p>Formula:C22H21FN4Purity:98%Color and Shape:SolidMolecular weight:360.43SHP2/HDAC-IN-1
CAS:<p>SHP2/HDAC-IN-1: dual SHP2/HDAC inhibitor, IC50: 20.4 nM/25.3 nM, boosts antitumor immunity, aids cancer immunotherapy research.</p>Formula:C34H35Cl2N7O3Color and Shape:SolidMolecular weight:660.59Acefylline piperazine
CAS:<p>Acefylline piperazine, a less toxic theophylline derivative, treats asthma and bronchitis by bronchodilation, stimulating respiration and CNS.</p>Formula:C9H10N4O4·xC4H10N2Color and Shape:SolidMolecular weight:562.54
