Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2611 products of "Chromatin/Epigenetics"
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SIRT1-IN-2
CAS:SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1) with an IC 50 of 1.6 μM [1].Formula:C13H15ClN2OColor and Shape:SolidMolecular weight:250.72Piribedil Maleate
CAS:Piribedil Maleate is a direct agonist of dopamine that acts by showing selectivity for the D3 subtype.Formula:C20H22N4O6Purity:98%Color and Shape:SolidMolecular weight:414.41AC430
CAS:AC430, a specific JAK2 inhibitor for cancer and autoimmune therapy, excels in preclinical trials with low doses. Developed by Ambit.Formula:C19H16FN5OColor and Shape:SolidMolecular weight:349.36HDAC-IN-44
CAS:HDAC-IN-44 is an HDAC inhibitor (IC50: 61.2 nM) with strong anti-cancer effects.Formula:C26H27BrN4O4Color and Shape:SolidMolecular weight:539.42NC-III-49-1
CAS:NC-III-49-1: potent BET inhibitor, binds BRD4/BRDT, inhibits cell growth, reduces c-Myc expression.Formula:C44H50N4O11S2Color and Shape:SoildMolecular weight:875.02BAY-6035-R-isomer
CAS:BAY-6035 is an inhibitor of the methylation of MEKK2 peptide.Formula:C22H28N4O3Color and Shape:SolidMolecular weight:396.48HDAC-IN-43
CAS:HDAC-IN-43: potent HDAC 1/3/6 inhibitor (IC50: 82 nM HDAC1, 45 nM HDAC3, 24 nM HDAC6); weak PI3K/mTOR (IC50: 3.6μM, 3.7μM); anti-proliferative.Formula:C22H28N6O4Color and Shape:SolidMolecular weight:440.5TFMB-(S)-2-HG
CAS:TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.Formula:C13H11F3O4Purity:98.07%Color and Shape:SolidMolecular weight:288.22Ref: TM-T24871
2mg34.00€5mg50.00€10mg79.00€25mg146.00€50mg227.00€100mg339.00€500mg713.00€1mL*10mM (DMSO)49.00€SYK/JAK-IN-1
CAS:SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.Formula:C24H26N8O3Color and Shape:SolidMolecular weight:474.52HDAC3 Inhibitor
CAS:HDAC3 inhibitor: allosteric, Ki=0.16 nM, favors HDAC3 over HDAC1/2, targets specific leukemia cells, EC50=36.37-151.7 nM.Formula:C20H23N3O2Color and Shape:SolidMolecular weight:337.42NSD3-IN-3
CAS:"NSD3-IN-3, a potent anticancer agent, inhibits NSD3 (IC50: 1.86 μM) and hampers H460 lung cancer cell growth."Formula:C15H17N5O2SColor and Shape:SolidMolecular weight:331.39MAT2A-IN-4
CAS:MAT2A-IN-4 can be used for the cancer research that is an inhibitor of methionine adenosyltransferase 2A (MAT2A)[1].Formula:C18H16ClN3OColor and Shape:SolidMolecular weight:325.79NSD3-IN-2
CAS:NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.Formula:C17H15N5OSColor and Shape:SolidMolecular weight:337.4Depudecin
CAS:Depudecin, a polyketide from Alternaria brassicicola, has an 11-carbon chain with two epoxides and six stereocenters, inhibits HDAC, and is anti-angiogenic.Formula:C11H16O4Color and Shape:SolidMolecular weight:212.24PRMT5-IN-10
CAS:PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.Formula:C13H17N5O4Color and Shape:SolidMolecular weight:307.31Dot1L-IN-2
CAS:Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectivelyFormula:C27H24N8OPurity:98%Color and Shape:SolidMolecular weight:476.53CBP/p300-IN-10
CAS:CBP/p300-IN-10, potent EP300/CREBBP inhibitor; IC50: 26 nM/39 nM. Potential for cancer research.Formula:C25H24F5N5O3Color and Shape:SolidMolecular weight:537.48OTS186935
CAS:OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).Formula:C25H26ClN5O2Purity:98%Color and Shape:SolidMolecular weight:463.96PF-00956980
CAS:PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.Formula:C18H26N6OColor and Shape:SolidMolecular weight:342.44BRM/BRG1 ATP Inhibitor-3
CAS:BRM/BRG1 ATP Inhibitor-3 targets BRM/BRG1 (IC50: 10.4/19.3 nM) for cancer/BAF disorder research.Formula:C26H25N5O2S2Color and Shape:SolidMolecular weight:503.64ZLD2218
CAS:ZLD2218, a potent inhibitor of BRD4 with an IC50 value of 107 nM, has been demonstrated to mitigate kidney injury and fibrosis through extensive studies.Formula:C22H18N4OColor and Shape:SolidMolecular weight:354.4CPI-1612
CAS:CPI-1612: Oral EP300/CBP HAT inhibitor, IC50 8.1 nM, has anticancer properties.Formula:C27H26N6OColor and Shape:SolidMolecular weight:450.53PRMT5-IN-C17
CAS:PRMT5-IN-C17 is a novel potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor.Formula:C18H17N3O4SColor and Shape:SolidMolecular weight:371.41GPI-15427
CAS:GPI-15427: a potent PARP-1 inhibitor, crosses the blood-brain barrier, boosts TMZ's effects on CNS tumors, and sensitizes cancer to radiotherapy.Formula:C20H20N4O2Color and Shape:SolidMolecular weight:348.4MIV-6
CAS:MIV-6 is an inhibitor of the menin-mixed lineage leukemia interaction.Formula:C27H35N3OColor and Shape:SolidMolecular weight:417.595WKS
CAS:5WKS, or ZINC97756584, is a G9a inhibitor targeting H3K9me2 for gene silencing research in autoimmune diseases and tumors.Formula:C24H36ClN5O2Purity:98%Color and Shape:SolidMolecular weight:462.03SIRT2-IN-10
CAS:SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases.Formula:C28H21N5OSColor and Shape:SolidMolecular weight:475.56SRI-42127
CAS:SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR that inhibits tumor growth and reduces neuropathic pain following nerve injury.Formula:C19H20N6OPurity:99.66%Color and Shape:SolidMolecular weight:348.4KCN1
CAS:KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.Formula:C26H27NO5SColor and Shape:SolidMolecular weight:465.56A2AAR/HDAC-IN-2
CAS:A2AAR/HDAC-IN-2: potent dual A2AAR/HDAC inhib., Ki 10.3 nM, IC50 18.5 nM, anti-tumor potential.Formula:C23H26N6O4Color and Shape:SolidMolecular weight:450.49CL67
CAS:CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.Formula:C38H42N10O2Color and Shape:SolidMolecular weight:670.81CTX-0124143
CAS:CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.Formula:C17H13FN2O3SPurity:98.24%Color and Shape:SolidMolecular weight:344.36PBRM1-BD2-IN-6
CAS:PBRM1-BD2-IN-6: potent PBRM1 inhibitor with 0.22 µM IC50, anti-cancer research potential.Formula:C16H15ClN2OColor and Shape:SolidMolecular weight:286.76PDAT
CAS:PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.Formula:C15H23N3Purity:98%Color and Shape:SolidMolecular weight:245.36Aurora Kinases-IN-3
CAS:Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.Formula:C20H16F3N3O4Color and Shape:SolidMolecular weight:419.35TM6008
CAS:TM6008 is an inhibitor of prolyl hydroxylase that protects against cell death after hypoxia.Formula:C21H17N5O3Purity:98%Color and Shape:SolidMolecular weight:387.39MAT2A inhibitor 3
CAS:MAT2A inhibitor 3 can be used in the cancer research.Formula:C16H14ClN3OColor and Shape:SolidMolecular weight:299.75SRTCX1003
CAS:SRTCX1003, a SIRT1 activator, suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.Formula:C23H23N5O3SColor and Shape:SolidMolecular weight:449.53JAK3i
CAS:JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.Formula:C18H15FN4O3Purity:98.61% - 99.81%Color and Shape:SolidMolecular weight:354.34MAT2A-IN-7
CAS:MAT2A-IN-7 inhibits MAT2A in various cancers, especially MTAP-deficient cancer cells, with potential for research use.Formula:C17H13ClF3N3O2Color and Shape:SolidMolecular weight:383.75SKF 91488 dihydrochloride
CAS:histamine N-methyltransferase inhibitorFormula:C7H19Cl2N3SPurity:98%Color and Shape:SolidMolecular weight:248.22ZIKV-IN-3
CAS:ZIKV-IN-3, an andrographolide derivative, inhibits ZIKV NS5 MTase (IC50: 18.34 μM) and replication. Used for Zika virus research.Formula:C39H41NO4Color and Shape:SolidMolecular weight:587.75ART-IN-1
CAS:ART-IN-1 (compound 7) is a selective inhibitor of PARP with IC 50 s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively [1].Formula:C14H13NO2SColor and Shape:SolidMolecular weight:259.32IHCH-3064
CAS:IHCH-3064: dual-action cancer immunotherapy, A2AR affinity (Ki 2.2 nM), selective HDAC1 inhibitor (IC50 80.2 nM).Formula:C25H21N9O2Color and Shape:SolidMolecular weight:479.49Povorcitinib
CAS:Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).Formula:C23H22F5N7OColor and Shape:SolidMolecular weight:507.469HDAC6/8/BRPF1-IN-1
CAS:HDAC6/8/BRPF1-IN-1 is a cancer-research inhibitor for HDAC6, HDAC8, BRPF1 with IC50: 344-908 nM and Kd: 175.2 nM.Formula:C18H17N3O5SColor and Shape:SolidMolecular weight:387.41Trotabresib
CAS:Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.Formula:C21H21NO4SPurity:99.86%Color and Shape:SolidMolecular weight:383.46Ref: TM-T36395
1mg92.00€5mg188.00€10mg311.00€25mg528.00€50mg755.00€100mg1,017.00€1mL*10mM (DMSO)215.00€BRD4 Inhibitor-26
BRD4 Inhibitor-26: blocks BRD4 (BD1 and BD2) with IC50 of 0.82 μM & 1.94 μM; used in ovarian cancer research.Formula:C29H27N5O6SColor and Shape:SolidMolecular weight:573.62I-BET151 dihydrochloride
CAS:I-BET 151 dihydrochloride is a BET bromodomain inhibitor that prevents BET from recruiting to chromatin.Formula:C23H23Cl2N5O3Purity:98%Color and Shape:SolidMolecular weight:488.37Vibsanin A
CAS:Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.Formula:C25H38O4Color and Shape:SolidMolecular weight:402.57
