Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2602 products of "Chromatin/Epigenetics"
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(1S,2R)-Tranylcypromine hydrochloride
CAS:(1S,2R)-Tranylcypromine hydrochloride ((1S,2R)-SKF 385), a potent antidepressant, functions by inhibiting both MAO and LSD1.Formula:C9H12ClNColor and Shape:SolidMolecular weight:169.651CAY10669
CAS:CAY10669 inhibits PCAF (IC50 = 662 μM), is twice as potent as anacardic acid, and reduces H4 acetylation in HepG2 cells at 30-60 μM.Formula:C20H22O4Color and Shape:SolidMolecular weight:326.39BAY1238097
CAS:BAY1238097 is a BET inhibitor with anticancer activity and antiproliferative activity for the study of advanced refractory malignancies.Formula:C25H33N5O3Purity:98.1% - 98.79%Color and Shape:SolidMolecular weight:451.56Ref: TM-T12660L
1mg49.00€5mg101.00€10mg172.00€25mg355.00€50mg620.00€100mg1,044.00€200mg1,404.00€1mL*10mM (DMSO)113.00€UNC6212 (Kme2)
UNC6212 (Kme2), a dimethyllysine (Kme2)-containing ligand, has a K D for CBX5 of 5.7 μM .Formula:C39H53N7O11Color and Shape:SolidMolecular weight:795.88OM-137
CAS:OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.Formula:C13H14N4O3SColor and Shape:SolidMolecular weight:306.34BAY-598 R-isomer
CAS:BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.Formula:C22H20Cl2F2N6O3Color and Shape:SolidMolecular weight:525.34PS432
CAS:PS432 inhibits atypical PKCs, targets PIF-pocket, reduces tumors in mice sans side effects.Formula:C25H19ClN2O5SPurity:98%Color and Shape:SolidMolecular weight:494.95CMP-5 hydrochloride
CAS:CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.Formula:C21H22ClN3Purity:98%Color and Shape:SolidMolecular weight:351.87PBRM1-BD2-IN-1
CAS:PBRM1-BD2-IN-1: Selective PBRM1 inhibitor with Kd 0.7μM, IC50 0.2μM, useful in cancer research.Formula:C17H19ClN2OColor and Shape:SolidMolecular weight:302.8HDAC3-IN-T326
CAS:HDAC3-IN-T326: potent, selective HDAC3 inhibitor, boosts NF-κB acetylation, activates latent HIV gene expression.Formula:C21H18N6O3SPurity:98%Color and Shape:SolidMolecular weight:434.47BF1
CAS:BF1 is an inhibitor of HAT (histone acetyltransferase) active both in vitro and in vivo.Formula:C12H12ClN3SColor and Shape:SolidMolecular weight:265.76Dimethyl-bisphenol A
CAS:DMBPA inhibits HIF-1α, promotes its degradation by detaching Hsp90, and reduces Vegfa mRNA expression.Formula:C17H20O2Color and Shape:SolidMolecular weight:256.34PARP-2/1-IN-2
CAS:PARP-2/1-IN-2, Veliparib's enantiomer, inhibits PARP-1/2 (Ki: 5/2 nM) with 3 nM EC50 in cell assay.Formula:C13H16N4OColor and Shape:SolidMolecular weight:244.29IACS-9571 hydrochloride
CAS:IACS-9571 hydrochloride: potent TRIM24/BRPF1 inhibitor; IC50 = 8 nM (TRIM24); Kd = 31 nM (TRIM24), 14 nM (BRPF1).Formula:C32H43ClN4O8SColor and Shape:SolidMolecular weight:679.22TC-E 5001
CAS:dual tankyrase (TNKS) inhibitorFormula:C20H19N5O3SPurity:98%Color and Shape:SolidMolecular weight:409.46aPKC-I
CAS:aPKC-I specifically inhibits PKCζ/i, blocks VEGF effects, and prevents IR-induced permeability in cells and live models.Formula:C15H17NO4SColor and Shape:SolidMolecular weight:307.36DDO-2093 dihydrochloride
DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.Formula:C29H39Cl3FN9O3Color and Shape:SolidMolecular weight:687.04p32 Inhibitor M36
CAS:p32 inhibitor M36 is an inhibitor of p32 mitochondrial protein. It binds directly to p32 and inhibits the p32 association with LyP-1.Formula:C23H28N8O2Purity:98%Color and Shape:SolidMolecular weight:448.52BET-BAY 002 (S enantiomer)
CAS:The S-enantiomer of BET-BAY 002, referred to as BET-BAY 002 S enantiomer, is a potent inhibitor of BET (Bromodomain and Extra-Terminal motif proteins).Formula:C22H18ClN5OPurity:98%Color and Shape:SolidMolecular weight:403.86NAT2-IN-1
CAS:NAT2-IN-1 (APA) is a selective inhibitor of the drug metabolism enzyme N-acetyltransferase 2 (NAT2), capable of targeting and eliminating cells with slow NAT2Formula:C19H20N4O3Color and Shape:SolidMolecular weight:352.39Bromodomain IN-1
CAS:Bromodomain IN-1 is an inhibitor of Bromodomain.Formula:C22H23ClN4O3SPurity:98%Color and Shape:SolidMolecular weight:458.96JAK3/BTK-IN-2
CAS:JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.
Formula:C25H32N8O2Purity:99.64% - 99.87%Color and Shape:SolidMolecular weight:476.57SC-10
CAS:SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.Formula:C17H22ClNO2SPurity:99.24% - 99.58%Color and Shape:SolidMolecular weight:339.88DM-01
CAS:DM-01 is a potent and selective inhibitor of EZH2.Formula:C23H24F3N3O2Color and Shape:SolidMolecular weight:431.45UNC0379 TFA
CAS:UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.Formula:C25H36F3N5O4Color and Shape:SolidMolecular weight:527.589BRD4884
CAS:BRD4884 is a highly selective and efficient HDAC1 and HDAC2 inhibitor that also inhibits HDAC3, used in research on neurological disorders.Formula:C18H19FN2O2Purity:99.19% - 99.21%Color and Shape:SolidMolecular weight:314.35Tinostamustine HCl
CAS:Tinostamustine (EDO-S101) is an alkylating HDACi fusion molecule, enhancing potency and overcoming drug resistance.Formula:C19H29Cl3N4O2Color and Shape:SolidMolecular weight:451.82Helenalin Acetate
CAS:Helenalin Acetate: anti-inflammatory, anti-cancer, hinders C/EBPß and p300 cooperation.Formula:C17H20O5Purity:98%Color and Shape:SolidMolecular weight:304.34F-amidine
CAS:F-amidine is a bioavailable irreversible PAD4 inactivator.Formula:C14H19FN4O2Color and Shape:SolidMolecular weight:294.32CCT077791
CAS:CCT077791 is a potent inhibitor of p300 and PCAF histone acetyltransferase activity for cancer research.Formula:C9H5ClN2O3SPurity:98.60%Color and Shape:SolidMolecular weight:256.67PB118
PB118 clears Aβ, boosts phagocytosis, enhances tubulin networks, reduces p-tau & inflammation in AD; HDAC6 IC50: 5.6 nM.Formula:C18H19FN2O2Color and Shape:SoildMolecular weight:314.35HDAC/CK2-IN-1
CAS:HDAC/CK2-IN-1 (compound 38) acts as an inhibitor of HDAC1 (IC 50 = 1.46 μM), HDAC6 (IC 50 = 0.66 μM), and CK2 (IC 50 = 3.67 μM). It demonstrates promising antiproliferative effects on various cell lines, including Jurkat, MCF-7, HCT-116, and HL-60.Formula:C15H18Br4N4O2Color and Shape:SolidMolecular weight:605.95Farnesylthiotriazole
CAS:Farnesylthiotriazole is a persistent PKC activator agent.Formula:C17H27N3SPurity:98%Color and Shape:SolidMolecular weight:305.48Tenovin-D3
CAS:Tenovin-D3 is a sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner.Formula:C22H27Cl3N4O3SPurity:98%Color and Shape:SolidMolecular weight:533.9ML399
CAS:ML399 inhibits menin–MLL interaction, selectively blocking oncogenic MLL signaling in leukemia cells, supporting functional genomics and therapeutic research.Formula:C27H28FN3O2Purity:97.84% - 98.20%Color and Shape:SolidMolecular weight:445.53Dot1L-IN-5
CAS:Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].Formula:C23H19ClF2N8O5SColor and Shape:SolidMolecular weight:592.96HIF-1α-IN-3
CAS:HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].Formula:C19H17N5O2Color and Shape:SolidMolecular weight:347.37(R)-BAY1238097
CAS:(R)-BAY1238097 is a selective inhibitor against the binding of BET proteins to histones, used in acute myeloid leukemia (AML) and multiple myeloma (MM) studies.Formula:C25H33N5O3Purity:98.77%Color and Shape:SolidMolecular weight:451.56Ref: TM-T13442
1mg49.00€5mg101.00€10mg172.00€25mg355.00€50mg620.00€100mg1,044.00€200mg1,404.00€1mL*10mM (DMSO)113.00€CAY10721
CAS:CAY10721 inhibits SIRT3 (39% at 200 μM), linked to OSCC and breast cancer; lowers OSCC growth, enhances radio/chemo sensitivity.Formula:C18H13N3O3SColor and Shape:SolidMolecular weight:351.38JNJ-9350
CAS:JNJ-9350: SMOX inhibitor (IC50 0.01 μM), PAO inhibitor (IC50 0.79 μM), for cancer research.Formula:C25H22N6OColor and Shape:SolidMolecular weight:422.48CSV0C018875 Hydrochloride
CAS:CSV0C018875 Hydrochloride: Novel G9a inhibitor with low toxicity, effective in enzyme/cell assays, outperforms BIX-0129.Formula:C18H18Cl2N2OColor and Shape:SolidMolecular weight:349.255HIF-IN-33
CAS:HIF-IN-33 is an inhibitor of HIF pathway.Formula:C21H17F3N4O2Purity:98%Color and Shape:SolidMolecular weight:414.38Bizine
CAS:Bizine, a Phenelzine analogue, selectively inhibits LSD1 (Ki=59 nM), modulates histone methylation in cancer, and may have neuroprotective uses.Formula:C18H23N3OColor and Shape:SolidMolecular weight:297.39Y02224
CAS:Y02224 is a BET inhibitor. It shows the reasonable antiproliferative effect on leukemia cells.Formula:C20H17BrN2O4SPurity:98%Color and Shape:SolidMolecular weight:461.33MC4343
MC4343, a potent dual inhibitor targeting both EZH2 and histone deacetylase, presents promising potential for cancer research applications.Formula:C36H41N5O4Color and Shape:SolidMolecular weight:607.74TK4b
CAS:TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) & 19.40 nM (JAK2).Formula:C21H22N2O2Color and Shape:SolidMolecular weight:334.41BET-BAY 002
CAS:BET-BAY 002 is an effective BET bromodomain inhibitor demonstrating efficacy in vivo and in vitro against multiple myeloma and leukaemia models.Formula:C22H18ClN5OColor and Shape:SolidMolecular weight:403.86UMB-136
CAS:UMB-136 is a bromodomain BRD4 inhibitor that acts by significantly inducing HIV-1 reactivation.Formula:C24H27N5O2Purity:98%Color and Shape:SolidMolecular weight:417.5Fagaronine chloride
CAS:Fagaronine chloride is a potent inhibitor of Topoisomerases I.Formula:C21H20ClNO4Color and Shape:SolidMolecular weight:385.84M133
CAS:M133 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.Formula:C23H24N4OS2Color and Shape:SolidMolecular weight:436.59
