Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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Vafidemstat
CAS:<p>Vafidemstat (ORY-2001) is a lysine-histone demethylase (LSD1)/MAO-B inhibitor for the study of neurological disorders.</p>Formula:C19H20N4O2Purity:99.53%Color and Shape:SolidMolecular weight:336.39CD235
CAS:<p>CD235 is a structurally similar analog of CD161. CD161 is an orally bioavailable inhibitor of BET bromodomain.</p>Formula:C26H20FN5O2Purity:98%Color and Shape:SolidMolecular weight:453.47GSK-3484862
CAS:<p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>Formula:C19H19N5OSPurity:99.87% - 99.963%Color and Shape:SolidMolecular weight:365.45YM-08
CAS:<p>YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].</p>Formula:C19H17N3OS2Purity:98%Color and Shape:SolidMolecular weight:367.49MAK683-CH2CH2COOH
CAS:<p>MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.</p>Formula:C23H21FN6O3Purity:98%Color and Shape:SolidMolecular weight:448.45(1s,4s)-Menin-MLL inhibitor-23
<p>(1s,4s)-Menin-MLL Inhibitor-23, an enantiomer of Menin-MLL Inhibitor-23 (Example 99A), functions as an inhibitor of the menin-MLL interaction [1].</p>Formula:C36H53FN6O4Color and Shape:SolidMolecular weight:652.84PHD2/HDACs-IN-1
CAS:<p>PHD2/HDACs-IN-1: strong PHD2/HDAC inhibitor (IC50: 1.15-26.60 μM), low-toxicity, protects kidneys from cisplatin-induced AKI.</p>Formula:C18H19N9O4Color and Shape:SolidMolecular weight:425.4BRD-IN-3
CAS:<p>BRD-IN-3 is a highly potent PCAF bromodomain (BRD) inhibitor (IC50: 7 nM). It also exhibits activity against GCN5 and FALZ.</p>Formula:C21H25N5O3Purity:98%Color and Shape:SolidMolecular weight:395.45SMYD3-IN-1
CAS:<p>SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).</p>Formula:C28H31ClN4O3Purity:98%Color and Shape:SolidMolecular weight:507.02TCS HDAC6 20b
CAS:<p>TCS HDAC6 20b (HDAC6-IN-7) is an HDAC6 inhibitor that blocks the growth of breast cancer cells and can be used in cancer research.</p>Formula:C26H44N2O4SPurity:>99.99%Color and Shape:SolidMolecular weight:480.7KDM4-IN-2
CAS:<p>KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.</p>Formula:C25H26N6OPurity:98%Color and Shape:SolidMolecular weight:426.51MK-0626
CAS:<p>MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.</p>Formula:C22H24F2N6O2Purity:99.47% - >99.99%Color and Shape:SolidMolecular weight:442.46Tankyrase-IN-5
CAS:<p>Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2, with half-maximal inhibitory</p>Formula:C17H18N2O2Purity:98%Color and Shape:SolidMolecular weight:282.34PRMT5-IN-28
CAS:<p>PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processes</p>Formula:C18H19ClN4O5Purity:98%Color and Shape:SolidMolecular weight:406.82Brepocitinib
CAS:<p>Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).</p>Formula:C18H21F2N7OPurity:99.82%Color and Shape:SolidMolecular weight:389.4JAK-IN-5
CAS:<p>JAK-IN-5 is a JAK inhibitor.</p>Formula:C27H31FN6OPurity:98.1% - 99.37%Color and Shape:SolidMolecular weight:474.57PHD-IN-2
CAS:<p>PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of</p>Formula:C26H27N7O4Purity:98%Color and Shape:SolidMolecular weight:501.54PRMT5-IN-29
CAS:<p>PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].</p>Formula:C18H20Cl3N5O5Purity:98%Color and Shape:SolidMolecular weight:492.74PRMT5-IN-25
CAS:<p>PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1</p>Formula:C24H21F3N6OPurity:98%Color and Shape:SolidMolecular weight:466.46PARP7-IN-15
CAS:<p>PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].</p>Formula:C23H24F6N6O4Purity:98%Color and Shape:SolidMolecular weight:562.46KDM5-C70
CAS:<p>KDM5-C70 is an ethyl ester derivative of KDM5-C49.</p>Formula:C17H28N4O3Purity:97.63% - 99.86%Color and Shape:SolidMolecular weight:336.43Pim-1 kinase inhibitor 5
CAS:<p>Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-</p>Formula:C22H13Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:406.26Sirtuin-1 inhibitor 1
CAS:<p>Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.</p>Formula:C20H17N3O2Purity:99.1%Color and Shape:SolidMolecular weight:331.37BRD7-IN-1
CAS:<p>BRD7-IN-1, a BI7273 derivative, forms PROTAC VZ185, targeting BRD7/9 with DC50s of 4.5/1.8 nM via VHL ligand linkage.</p>Formula:C22H28Cl2N4O3Purity:98.95%Color and Shape:SolidMolecular weight:467.39Aurora Kinases-IN-4
CAS:<p>Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.</p>Formula:C26H28N8OPurity:98%Color and Shape:SolidMolecular weight:468.55Physachenolide C
CAS:<p>Physachenolide C, a selective BET inhibitor, induces apoptosis and arrests the cell cycle at the G0-G1 phase, exhibiting antitumor activity [1].</p>Formula:C30H40O9Purity:98%Color and Shape:SolidMolecular weight:544.63PHD2-IN-1
CAS:<p>PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].</p>Formula:C21H23ClN4O5Purity:98%Color and Shape:SolidMolecular weight:446.88BET-IN-16
CAS:<p>BET-IN-16 (Comp I), a bromodomain and extra-terminal (BET) inhibitor, demonstrates anticancer activity by impeding the growth of prostate cancer cells.</p>Formula:C31H25N5O3Purity:98%Color and Shape:SolidMolecular weight:515.56Antitumor agent-101
CAS:<p>Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of 8.5 nM for G9a and 5.5 nM for</p>Formula:C26H38N6O3Purity:98%Color and Shape:SolidMolecular weight:482.62SJ1461
CAS:<p>SJ1461 is a potent, orally active inhibitor of the BET family, selectively targeting and inhibiting BRD2 (BD1), BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) with</p>Formula:C21H18ClN7OS2Purity:98%Color and Shape:SolidMolecular weight:484CBP-IN-1
CAS:<p>CBP-IN-1 (compound 12) acts as a potent CBP inhibitor exhibiting an IC50 of 1.5 nM and additionally suppresses CBP BRET and BRD4(1) with IC50 values of 690 nM</p>Formula:C27H33F2N7OPurity:98%Color and Shape:SolidMolecular weight:509.59Eleven-Nineteen-Leukemia Protein IN-2
CAS:<p>Eleven-Nineteen-Leukemia Protein IN-2 (compound 23), an ENL inhibitor, exhibits an IC50 of 10.7 nM and is utilized for leukemia research [1].</p>Formula:C22H23N5O2Purity:98%Color and Shape:SolidMolecular weight:389.45LSD1-UM-109
CAS:<p>LSD1-UM-109 is a highly potent and reversible inhibitor of LSD1, demonstrating an IC50 of 3.1 nM.</p>Formula:C29H27FN6Purity:98%Color and Shape:SolidMolecular weight:478.56Bromodomain inhibitor-12
CAS:<p>Bromodomain Inhibitor-12 (example 303) is a research compound utilized in the study of autoimmune and inflammatory diseases [1].</p>Formula:C28H38N4O5Purity:98%Color and Shape:SolidMolecular weight:510.63MAT2A-IN-10
CAS:<p>MAT2A-IN-10 (Compound 28), an orally active inhibitor of MAT2A, exhibits an IC50 of 26 nM and is utilized in cancer research [1].</p>Formula:C27H24F2N6O4Purity:98%Color and Shape:SolidMolecular weight:534.51PIM1-IN-4
CAS:<p>PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.</p>Formula:C27H25BrCl2CuN6OPurity:98%Color and Shape:SolidMolecular weight:663.88Eleven-Nineteen-Leukemia Protein IN-3
CAS:<p>ENL YEATS inhibitor Eleven-Nineteen-Leukemia Protein IN-3, IC50 15.4 nM, orally active, suppresses MYC, stabilizes ENL in vitro.</p>Formula:C28H27N5O2Purity:98%Color and Shape:SolidMolecular weight:465.55MAT2A-IN-12
CAS:<p>MAT2A Allosteric Inhibitor 2 is a potent, selective inhibitor exhibiting an IC50 of 5 nM and demonstrates nanomolar efficacy (IC50 = 5 μM) in proliferation</p>Formula:C20H17NO3Purity:98%Color and Shape:SolidMolecular weight:319.35CBP/p300-IN-21
CAS:<p>CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibits</p>Formula:C19H16ClNO4Purity:98%Color and Shape:SolidMolecular weight:357.79BRD4 Inhibitor-28
CAS:<p>BRD4 Inhibitor-28 (Compound 18), an orally active molecule, selectively inhibits the bromodomains of BRD4 (BRD4-BD1 and BRD4-BD2) with IC50 values of 15 and 55</p>Formula:C23H21N3O3Purity:98%Color and Shape:SolidMolecular weight:387.43Bromodomain inhibitor-12 (edisylate)
CAS:<p>Bromodomain Inhibitor-12 Edisylate (example 303) serves as a bromodomain inhibitor applicable to autoimmune and inflammatory disease research [1].</p>Formula:C30H44N4O11S2Purity:98%Color and Shape:SolidMolecular weight:700.82HIF-2α-IN-9
CAS:<p>HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes within</p>Formula:C12H13F5O4S2Purity:98%Color and Shape:SolidMolecular weight:380.35(S,R)-CFT8634
CAS:<p>(S,R)-CFT8634 is a selective and orally active BRD9 protein degrader with potential for researching BRD9-mediated disorders, such as abnormal cellular</p>Formula:C37H45F3N6O5Purity:98%Color and Shape:SolidMolecular weight:710.79FM-479
CAS:<p>FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.</p>Formula:C25H26N6O2Purity:98%Color and Shape:SolidMolecular weight:442.523WM-586
CAS:<p>WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.</p>Formula:C20H20F3N5O3SPurity:98%Color and Shape:SolidMolecular weight:467.47JG-2016
CAS:<p>JG-2016, as a histone acetyltransferase 1 inhibitor, inhibits growth of human cancer cell lines and inhibits enzymatic activity in cellulose.</p>Formula:C18H21ClN4O3Purity:99.00% - 99.37%Color and Shape:SolidMolecular weight:376.84GSK217
CAS:<p>GSK217 is a potent and selective inhibitor of the bromo and extraterminal domain (BET) second bromodomain (BD2) with high solubility, utilized in oncology and</p>Formula:C20H20N6OPurity:98%Color and Shape:SolidMolecular weight:360.41AGI-25696
CAS:<p>AGI-25696 inhibits MATA2, blocking MTAP-deleted tumor growth, potential for cancer research.</p>Formula:C27H18N4OPurity:98.40% - 99.74%Color and Shape:SolidMolecular weight:414.46JAK-IN-31
CAS:<p>JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,</p>Formula:C21H19N7O2S2Purity:98%Color and Shape:SolidMolecular weight:465.55ABBV-712
CAS:<p>ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases</p>Formula:C24H28N4O5Purity:98%Color and Shape:SolidMolecular weight:452.5
