Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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GSK737
CAS:<p>GSK737 is a dual inhibitor of BRD4 BD1 and BD2, exhibiting pIC50 values of 5.3 and 7.3, respectively.</p>Formula:C20H21N5O2Purity:98%Color and Shape:SolidMolecular weight:363.41AAPK-25
CAS:<p>AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.</p>Formula:C21H13Cl2N3O2SPurity:97.05%Color and Shape:SolidMolecular weight:442.32Demethyleneberberine chloride
CAS:<p>Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-</p>Formula:C19H18ClNO4Purity:98%Color and Shape:SolidMolecular weight:359.8Amelparib
CAS:<p>Amelparib (JPI-289) is an inhibitor of the poly-ADP-ribose polymerase.</p>Formula:C19H25N3O3Purity:98%Color and Shape:SolidMolecular weight:343.42BATCP
CAS:<p>BATCP is an inhibitor of histone deacetylases (HDAC) [1].</p>Formula:C23H28F3N3O6Color and Shape:SolidMolecular weight:499.487AKB-6899
CAS:<p>AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated</p>Formula:C14H11FN2O4Purity:97.87%Color and Shape:SolidMolecular weight:290.25Sirt2-IN-5
CAS:<p>Sirt2-IN-5 is a potent inhibitor of SIRT2.</p>Formula:C26H27Cl2N5O3Color and Shape:SolidMolecular weight:528.43MARK-IN-1
CAS:<p>MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).</p>Formula:C22H23F2N7OSPurity:98%Color and Shape:SolidMolecular weight:471.53XDM-CBP
CAS:<p>XDM-CBP is an effective and selective CBP/p300 bromodomain inhibitor.</p>Formula:C21H22N2O4Purity:98%Color and Shape:SolidMolecular weight:366.41DY-46-2
CAS:<p>DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.</p>Formula:C19H22N6O5SPurity:99.12% - 99.12%Color and Shape:SolidMolecular weight:446.48Prolyl Hydroxylase inhibitor 1
CAS:<p>Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).</p>Formula:C19H18ClN5O4Purity:98%Color and Shape:SolidMolecular weight:415.83K-756
CAS:<p>K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).</p>Formula:C24H27N5O3Purity:99.81%Color and Shape:SolidMolecular weight:433.5QL-1200186
CAS:<p>QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production following</p>Formula:C26H27N7O3Purity:98%Color and Shape:SolidMolecular weight:485.54JAK kinase-IN-1
CAS:<p>JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32</p>Formula:C17H19F2N7OSPurity:98%Color and Shape:SolidMolecular weight:407.44JAK-IN-25
CAS:<p>JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.</p>Formula:C19H17N5O4Purity:98%Color and Shape:SolidMolecular weight:379.37JAK-IN-17
<p>"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."</p>Formula:C33H38F2N6O8Color and Shape:SolidMolecular weight:684.69GSK-A
CAS:<p>GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.</p>Formula:C21H25N5O2Color and Shape:SolidMolecular weight:379.46BChE/HDAC6-IN-1
CAS:<p>BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6.</p>Formula:C34H43N5O5Purity:98%Color and Shape:SolidMolecular weight:601.74KDM2B-IN-1
CAS:<p>KDM2B-IN-1: Potent, specific KDM2B histone demethylase inhibitor for hyperproliferative disease research.</p>Formula:C21H30N4O2SColor and Shape:SolidMolecular weight:402.56HDAC/HSP90-IN-3
CAS:<p>HDAC/HSP90-IN-3, a dual inhibitor targeting fungal Hsp90 (IC50: 0.83 μM) & HDAC (IC50: 0.91 μM), counters azole-resistant C. albicans.</p>Formula:C26H33N5O6Color and Shape:SolidMolecular weight:511.57RK-701
CAS:<p>RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.</p>Formula:C26H30N4O3Color and Shape:SolidMolecular weight:446.54Aurora kinase inhibitor-8
CAS:<p>Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.</p>Formula:C30H29N7O3Color and Shape:SolidMolecular weight:535.6EPZ-030456
CAS:<p>EPZ-030456 is an effective and selective inhibitor of the SMYD3.</p>Formula:C28H34ClN5O4SColor and Shape:SolidMolecular weight:572.12PF-06679142
CAS:<p>PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.</p>Formula:C20H17F2NO3Purity:98%Color and Shape:SolidMolecular weight:357.35CC-90005
CAS:<p>CC-90005 is a potent, selective oral PKC-θ inhibitor with an IC50 of 8 nM, preferential over PKC-δ, and inhibits T cell activation.</p>Formula:C21H27F2N7O2Color and Shape:SolidMolecular weight:447.48PRMT5-IN-16
CAS:<p>PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.</p>Formula:C25H34N8O2Color and Shape:SolidMolecular weight:478.59Tyk2-IN-9
CAS:<p>Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.</p>Formula:C20H17N9Purity:98%Color and Shape:SolidMolecular weight:383.41OM-1700
CAS:<p>OM-1700 inhibits tankyrase 1 (IC50=127 nM) and 2 (IC50=14 nM); hinders colon cancer cell growth, COLO 320DM (GI50=650 nM).</p>Formula:C25H23FN6O2Color and Shape:SolidMolecular weight:458.49FD1024
CAS:<p>FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.</p>Formula:C21H20F2N4O2SPurity:98%Color and Shape:SolidMolecular weight:430.47NMS-P515
CAS:<p>NMS-P515 is an effective, orally active, and stereospecific PARP-1 inhibitor (Kd: 16 nM and an IC50: 27 nM (in Hela cells)). It has anti-tumor activity.</p>Formula:C21H29N3O2Purity:98%Color and Shape:SolidMolecular weight:355.47CARM1-IN-3
CAS:<p>CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM for</p>Formula:C24H32N4O2Purity:98%Color and Shape:SolidMolecular weight:408.54RK-0133114
<p>RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.</p>Formula:C26H30N4O3Color and Shape:SolidMolecular weight:446.54JQKD82 dihydrochloride
CAS:<p>JQKD82 (JADA82) dihydrochloride, a cell-permeable and selective inhibitor of KDM5, enhances H3K4me3 levels, making it effective for multiple myeloma research [1].</p>Formula:C27H42Cl2N4O5Color and Shape:SolidMolecular weight:573.55QQN-00358
CAS:<p>QQN-00358 is a novel potent and selective tankyrase (TNKS) inhibitor.</p>Formula:C26H24F3N3O4Color and Shape:SolidMolecular weight:499.48PARP1-IN-7
CAS:<p>PARP1-IN-7 functions as an anticancer agent by inhibiting poly(ADP-ribose) polymerase-1 (PARP1).</p>Formula:C24H23N5OColor and Shape:SolidMolecular weight:397.47MS31
CAS:<p>MS31 is a potent and highly affinity inhibitor of spindlin 1 (SPIN1).</p>Formula:C20H27N3O2Purity:98%Color and Shape:SolidMolecular weight:341.45Upadacitinib tartrate
CAS:<p>Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.</p>Formula:C21H33F3N6O11Purity:98%Color and Shape:SolidMolecular weight:602.521CBP/p300-IN-15
CAS:<p>CBP/p300-IN-15 inhibits p300 (IC50: 2.5 nM) & CBP (28 nM), affects OVCAR-3 (EC50: 0.865 μM) & A2780 cells (2.71 μM) for ovarian cancer research.</p>Formula:C26H28N4O5Color and Shape:SolidMolecular weight:476.52Ro 32-0432 hydrochloride
CAS:<p>Ro 32-0432 is a selective, ATP-competitive, oral pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε.</p>Formula:C28H28N4O2Purity:98%Color and Shape:SolidMolecular weight:452.55BET-IN-9
CAS:<p>BET-IN-9 is a BET inhibitor[1].</p>Formula:C22H24N4O3Color and Shape:SolidMolecular weight:392.45PIM-IN-2
CAS:<p>PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .</p>Formula:C19H22N4O2Purity:98%Color and Shape:SolidMolecular weight:338.4SP-2-225
CAS:<p>SP-2-225, a selective inhibitor of HDAC6, augments the production of cancer-associated antigens and enhances macrophage antigen cross-presentation to T cells,</p>Formula:C28H34N2O3Purity:98%Color and Shape:SolidMolecular weight:446.58MARK-IN-2
CAS:<p>MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).</p>Formula:C18H18ClF2N5OSPurity:98%Color and Shape:SolidMolecular weight:425.88PIN1 inhibitor 2
CAS:<p>PIN1 inhibitor 2, compound 12, impedes PIN1, shows promise in breast cancer study, and has IC50 of 9.55 μM in MCF7 cells.</p>Formula:C16H21N3S2Color and Shape:SolidMolecular weight:319.49CBB1007
CAS:<p>CBB1007 is a potent, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).</p>Formula:C27H34N8O4Purity:98%Color and Shape:SolidMolecular weight:534.61AMPK activator 7
CAS:<p>AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.</p>Formula:C23H22F3N3O5Color and Shape:SolidMolecular weight:477.43PARP7-probe-1
CAS:<p>PARP7-probe-1: biotinylated, chemiluminescent PARP7 active site probe for research use.</p>Formula:C36H49F3N8O5SColor and Shape:SolidMolecular weight:762.89PRT543
CAS:<p>PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.</p>Formula:C17H17ClN4O4Color and Shape:SolidMolecular weight:376.79JAK-IN-24
CAS:<p>JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.</p>Formula:C20H25N5O2Color and Shape:SolidMolecular weight:367.44EZH2-IN-14
CAS:<p>EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.</p>Formula:C31H39N7O2Color and Shape:SolidMolecular weight:541.69
