Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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TC-A 2317 hydrochloride
CAS:<p>TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.</p>Formula:C19H29ClN6OPurity:98%Color and Shape:SolidMolecular weight:392.93TC-AC28
CAS:<p>TC-AC28 is a novel potent and selective Brd2(2) ligand.</p>Formula:C23H21N5O3Purity:98%Color and Shape:SolidMolecular weight:415.44Nesuparib
CAS:<p>Nesuparib, a potent PARP/TNKS1 inhibitor, has antitumor properties and potential for treating various diseases.</p>Formula:C23H24N6OPurity:99.71%Color and Shape:SolidMolecular weight:400.48GSK4028
CAS:<p>GSK4028 is the enantiomeric negative control of GSK4027, a PCAF/GCN5 bromodomain chemical probe, with a pIC50 of 4.9 in a TR-FRET assay.</p>Formula:C17H21BrN4OColor and Shape:SolidMolecular weight:377.28HL23
CAS:<p>HL23 is a histone deacetylase (HDAC) inhibitor that effectively targets hepatocellular carcinoma (HCC).</p>Formula:C44H44N2O7Purity:98%Color and Shape:SolidMolecular weight:712.83BRD4 Inhibitor-23
CAS:<p>BRD4 Inhibitor-23: potent, oral, IC50: BRD4 BD-1 6.21 nM, BD-2 1.44 nM. See WO2022033542A1 Example 1.</p>Formula:C22H19F2N3O4SColor and Shape:SolidMolecular weight:459.47HIF-2α-IN-6
CAS:<p>HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].</p>Formula:C15H13F4NO3SColor and Shape:SolidMolecular weight:363.33TCS 21311
CAS:<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formula:C27H25F3N4O4Purity:99.39% - ≥98%Color and Shape:SolidMolecular weight:526.51AMPK-IN-1
CAS:<p>AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.</p>Formula:C24H18ClN3O3Color and Shape:SolidMolecular weight:431.87EPZ011989 HCl(1598383-40-4 Free base)
CAS:<p>EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM.</p>Formula:C35H51N5O4·HClColor and Shape:SolidMolecular weight:642.27TCJL37
CAS:<p>TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.</p>Formula:C17H11ClF2N4O2Color and Shape:SolidMolecular weight:376.74CBP/p300-IN-19
CAS:<p>CBP/p300-IN-19 inhibits p300/CBP HAT (IC50: 1.4μM), less effective on PCAF/Myst3, shows anti-tumor properties.</p>Formula:C30H27N3O3Color and Shape:SolidMolecular weight:477.55GSK2646264
CAS:<p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>Formula:C24H26N2O2Color and Shape:SolidMolecular weight:374.48Gö 7874
CAS:<p>Gö 7874 is a potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC50 = 4 nM for rat brain PKC).</p>Formula:C27H26N4O4Color and Shape:SolidMolecular weight:470.52HSP70/SIRT2-IN-2
CAS:<p>HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].</p>Formula:C17H13N3S3Purity:98%Color and Shape:SolidMolecular weight:355.5LY3295668
CAS:<p>LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.</p>Formula:C24H26ClF2N5O2Purity:99.68%Color and Shape:SolidMolecular weight:489.95GNE-375
CAS:<p>GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.</p>Formula:C25H29N3O5Purity:98.99%Color and Shape:SolidMolecular weight:451.51HIF-2α agonist 2
CAS:<p>HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.</p>Formula:C13H8Br2N2O2SPurity:98.87%Color and Shape:SoildMolecular weight:416.09EPZ031686
CAS:<p>EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.</p>Formula:C26H34ClF3N4O4SPurity:99.67%Color and Shape:SolidMolecular weight:591.09E7016
CAS:<p>E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.</p>Formula:C20H19N3O3Purity:99.02%Color and Shape:SolidMolecular weight:349.38CPI-0610 carboxylic acid
CAS:<p>CPI-0610 carboxylic acid is a selective BET protein inhibitor with potential anticancer effects.</p>Formula:C20H15ClN2O3Purity:98.62%Color and Shape:SolidMolecular weight:366.8JAK-IN-3
CAS:<p>JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.</p>Formula:C18H20N4O3Purity:98.04% - 98.19%Color and Shape:SolidMolecular weight:340.38NPAS3-IN-1
CAS:<p>NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.</p>Formula:C10H5N3O2S3Purity:99.56%Color and Shape:SolidMolecular weight:295.36hRIO2 kinase ligand-1
CAS:<p>hRIO2 kinase ligand-1 is a potent ligand for hRIO2 kinase (Kd: 520 nM).</p>Formula:C17H14N2OPurity:99.89%Color and Shape:SolidMolecular weight:262.31CCT129202
CAS:<p>CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.</p>Formula:C23H25ClN8OSPurity:98.14%Color and Shape:SolidMolecular weight:497.02KDM4-IN-4
CAS:<p>KDM4-IN-4 is a KDM4 inhibitor with anticancer activity that inhibits the KDM4A-Tudor structural domain for cancer research.</p>Formula:C16H23NOPurity:99.61%Color and Shape:SolidMolecular weight:245.36AU-15330
CAS:<p>AU-15330 is a proteolytic targeting chimera (PROTAC) that simultaneously targets SMARCA4, SMARCA2, and PBRM1 for degradation and exhibits cytotoxicity in H3.3K27M cells but not in H3 wild-type cells. Cost-effective and quality-assured.</p>Formula:C39H49N9O5SPurity:98.21% - 99.62%Color and Shape:SolidMolecular weight:755.93PARP-1-IN-4
CAS:<p>PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.</p>Formula:C22H15Cl2N3O2Purity:99.82%Color and Shape:SolidMolecular weight:424.28FHT-1015
CAS:<p>FHT-1205 is a potent inhibitor (IC50 ≤ 10 nM) of SMARCA4/SMARCA2 ATPase (BRG1 and BRM).</p>Formula:C25H25N5O4S3Purity:98.57%Color and Shape:SolidMolecular weight:555.69HS94
CAS:<p>HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.</p>Formula:C15H15N5O2SPurity:95.04%Color and Shape:SolidMolecular weight:329.38Y06137
CAS:<p>Y06137, selective BET inhibitor, Kd 81 nM for BRD4(1), researched for castration-resistant prostate cancer treatment.</p>Formula:C27H32N4O2Purity:99.85%Color and Shape:SolidMolecular weight:444.57CeMMEC1
CAS:<p>CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).</p>Formula:C19H16N2O4Purity:98.9% - 99.92%Color and Shape:SolidMolecular weight:336.34Aurora B inhibitor 1
CAS:<p>Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.</p>Formula:C25H26ClF2N7O2Purity:98.37%Color and Shape:SolidMolecular weight:529.97L-Moses dihydrochloride
<p>L-Moses (L-45) dihydrochloride is the first, potent, selective p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor (Kd: 126 nM).</p>Formula:C21H26Cl2N6Color and Shape:SolidMolecular weight:433.38MC2652
<p>MC2652, a potent LSD1 inhibitor, suppresses leukemia (MV4-11, NB4) and impedes prostate cancer (LNCaP) cell growth.</p>Formula:C22H20N2OColor and Shape:SolidMolecular weight:328.41KDOAM-25 citrate
CAS:<p>KDOAM-25 citrate inhibits KDM5A/B/C/D (IC50: 71, 19, 69, 69 nM); boosts H3K4 methylation, hinders MM1S cell growth. [1]</p>Formula:C21H33N5O9Purity:98%Color and Shape:SolidMolecular weight:499.51BSI-401
CAS:<p>BSI-401 is an oral inhibitor of PARP-1. It can inhibit pancreatic cancer either when used alone or in synergy with Oxaliplatin.</p>Formula:C9H4INO4Color and Shape:SolidMolecular weight:317.037HDAC6-IN-13
<p>HDAC6-IN-13: potent, selective HDAC6 inhibitor; oral; IC50=0.019μM; targets HDAC1/2/3; crosses blood-brain barrier; anti-inflammatory.</p>Formula:C23H22N4OColor and Shape:SolidMolecular weight:370.45DS-9300
CAS:<p>DS-9300, an orally administered potent and selective inhibitor of EP300/CBP HAT, exhibits a significant inhibitory activity with an IC50 value of 28 nM.</p>Formula:C25H26F3N5O3Color and Shape:SolidMolecular weight:501.506K465
CAS:<p>6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.</p>Formula:C26H33ClFN9OPurity:99.78%Color and Shape:SolidMolecular weight:542.05Balomenib
CAS:<p>Balomenib is an inhibitor of the menin-MLL interaction, effectively blocking the men1-MLL4-43 interaction with an IC50 of less than 0.075 μM. It inhibits cell growth in MV4-11 (CC50 < 0.1 μM), MOLM-13 (CC50 0.1~0.5 μM), and HEK293 (CC50 < 2 μM) cells. Balomenib also exhibits antitumor activity.</p>Formula:C33H34F3N7O2Color and Shape:SolidMolecular weight:617.664O6BTG-C8-αGlu
CAS:<p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>Formula:C24H34BrN5O7SColor and Shape:SolidMolecular weight:616.525KH-259
<p>KH-259: potent, selective CNS-penetrant HDAC6 inhibitor with 0.26 μM IC50; shows antidepressant effects in mice.</p>Formula:C20H25N3O2Color and Shape:SolidMolecular weight:339.43BRD4-IN-7
CAS:<p>BRD4-IN-7, also known as compound 120, acts as a BRD4 inhibitor.</p>Formula:C29H24F2N4O3Color and Shape:SolidMolecular weight:514.52PAD2-IN-1 hydrochloride
<p>PAD2-IN-1 hydrochloride: potent, selective PAD2 inhibitor; 95x less on PAD4, 79x less on PAD3; benzimidazole derivative.</p>Formula:C25H30ClFN6O3Color and Shape:SolidMolecular weight:517PRMT5-IN-50
CAS:<p>PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.</p>Formula:C26H23F3N6OColor and Shape:SolidMolecular weight:492.496WIZ degrader 8
CAS:<p>WIZ degrader 8 (compound 10) is a potent and selective molecular glue degrader of the transcription factor WIZ, effectively inducing HbF expression. It promotes WIZ degradation and HbF induction, suggesting its potential use as an inhibitor for sickle cell disease.</p>Formula:C21H27N3O4Color and Shape:SolidMolecular weight:385.457BRD4 Inhibitor-33
CAS:<p>BRD4 Inhibitor-33 (example 13), a potent inhibitor of BRD4, is applicable in research related to both acute and chronic kidney diseases [1].</p>Formula:C24H20N4O2Color and Shape:SolidMolecular weight:396.44MAT2A-IN-19
CAS:<p>MAT2A-IN-19 (Compound I-3) is an inhibitor of methionine adenosyltransferase 2A (MAT2A), with an IC50 of 32.93 nM.</p>Formula:C23H15F5N6O3Color and Shape:SolidMolecular weight:518.396JPHM-2-167
CAS:<p>PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.</p>Formula:C30H28N6O2Color and Shape:SolidMolecular weight:504.582
