Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2615 products of "Chromatin/Epigenetics"
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ROPA
CAS:ROPA, a potent PKCalpha and PKCgamma activator, promotes tumor growth through PKC-activation.Formula:C28H32O6Purity:98%Color and Shape:SolidMolecular weight:464.55WW437
WW437 is a histone deacetylase (HDAC) inhibitor that exhibits potent anti-breast cancer activity both in vitro and in vivo.Formula:C23H27N5O4Color and Shape:SolidMolecular weight:437.49GNE-886
CAS:GNE-886 has a wide range of applications in life science related research.Formula:C28H30N6O3Purity:98%Color and Shape:SolidMolecular weight:498.59PARP7-IN-23
CAS:PARP7-IN-23 (compound 56) is a potent PARP7 inhibitor with an EC50 of 0.915 nM for pSTAT1 in NCI-H1373 cells, indicating its potential for cancer research.
Formula:C27H22F7N5O3Color and Shape:SolidMolecular weight:597.484LSD1-IN-13 hydrochloride
CAS:LSD1-IN-13 hydrochloride (7e) is an oral LSD1 inhibitor (IC50: 24.43 nM), promoting differentiation in AML cell lines.Formula:C23H30ClN3O2SColor and Shape:SolidMolecular weight:448.02CCW 28-3
CAS:CCW 28-3 is a novel potent covalent BRD4 degrader, degrading BRD4 in a proteasome- and RNF4-dependent manner without inhibiting RNF4 autoubiquitination activityFormula:C44H42Cl2N6O4SColor and Shape:SolidMolecular weight:821.81Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formula:C29H33ClN4O3SColor and Shape:SolidMolecular weight:553.12Dioleyl phosphatidylserine
CAS:Dioleyl phosphatidylserine is a phospholipid that can activate PKC-γ (Protein Kinase C-gamma) when the Ca2+ concentration is below 0.5 μM, specifically at a concentration of 100 μM.Formula:C42H78NO10PColor and Shape:SolidMolecular weight:788.045-Ph-IAA-AM
5-Ph-IAA-AM, eggshell-permeable analog of 5-Ph-IAA, boosts protein degradation in embryos, useful for studying proteins in C. elegans.Formula:C19H17NO4Color and Shape:SolidMolecular weight:323.34PAD-IN-2
CAS:PAD-IN-2, potent PAD4 inhibitor, IC50 <1 μM; targets autoimmune/cancer disorders.Formula:C27H28ClN5O2Color and Shape:SolidMolecular weight:490MRK-740-NC
CAS:MRK-740-NC is an inhibitor of the PRDM7/9 histone methyltransferase. Acting as the negative control compound for MRK-740, MRK-740-NC lacks inhibitory activity on PRDM7 and PRDM9 because the methylpyridine portion of MRK-740 is replaced with a phenyl group.Formula:C25H31N5O3Color and Shape:SolidMolecular weight:449.55PRMT5-IN-18
CAS:PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.Formula:C32H42N4O4Color and Shape:SolidMolecular weight:546.70Conophyllidine
CAS:Conophyllidine is a bisindole alkaloid and functions as a selective inhibitor of M2 polarization. It inhibits histone acetylation by targeting the histone acetyltransferase domain of the P300/CBP proteins. The IC50 of Conophyllidine for IL-4-induced arginase inhibition is 0.31 μM. This compound effectively induces tumor-associated macrophages (TAMs) to shift from an anti-inflammatory to an inflammatory state, thereby enhancing the recruitment and function of cytotoxic CD8+ T cells in the tumor microenvironment. Conophyllidine is useful for studying tumor-associated macrophages.Formula:C44H50N4O9Color and Shape:SolidMolecular weight:778.89KMT9-IN-1
CAS:KMT9-IN-1 (Compound 8) is a KMT9 inhibitor and an ethyl ester prodrug of compound 7b. Inside cells, KMT9-IN-1 releases the active form 7b through the action of esterases. It specifically associates with the KMT9 target within cells, leading to a reduction in H4K12me1 levels. KMT9-IN-1 exhibits antitumor activity against colon cancer and can be employed in research on prostate cancer and hepatocellular carcinoma.Formula:C36H47ClFN7O5Color and Shape:SolidMolecular weight:712.25EED ligand 1
EED ligand 1: potent PRC2 inhibitor targeting EED subunit.Formula:C19H19FN8OColor and Shape:SolidMolecular weight:394.41Protein kinase inhibitor 7
CAS:Protein kinase inhibitor 7 functions as an inhibitor of protein kinase A (PKA) and protein kinase C (PKC). It impacts the autocrine motility factor (AMF) signaling pathway without affecting cell motility.Formula:C12H15N3O2SMolecular weight:265.33MDH1/2-IN-1
CAS:MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.Formula:C25H33NO4Color and Shape:SolidMolecular weight:411.534Basroparib
CAS:Basroparib is an inhibitor of ribose polymerase (PARP) and has shown antitumour effects.Formula:C18H21F2N7O3Color and Shape:SolidMolecular weight:421.4L-Moses dihydrochloride
L-Moses (L-45) dihydrochloride is the first, potent, selective p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor (Kd: 126 nM).Formula:C21H26Cl2N6Color and Shape:SolidMolecular weight:433.38HDAC6-IN-59
CAS:HDAC6-IN-59 (Compound 38k) is a highly selective inhibitor of histone deacetylase 6 (HDAC6), with an IC50 of 3.12 nM and a 352-fold selectivity over HDAC1. It holds potential for research in esophageal cancer.Formula:C22H18ClN5O2Color and Shape:SolidMolecular weight:419.86IOR-160
CAS:IOR-160 is a dual inhibitor of casein kinase 2 (CK2) and HDAC. It exhibits high selectivity for CK2 with an IC50 of 1.7 nM and demonstrates broad inhibitory activity against HDAC (HDAC1, 2, 3, and 6) with IC50 values of 3.3 nM, 24.0 nM, 3.9 nM, and 13.0 nM, respectively, while showing low activity against HDAC8. IOR-160 modulates critical cell signaling pathways by inhibiting AKT phosphorylation and increasing α-tubulin acetylation. The compound reduces tumor growth and burden through its dual inhibition of CK2/HDAC and is relevant for research on triple-negative breast cancer.Formula:C23H25F3N4O6Color and Shape:SolidMolecular weight:510.46HbF inducer-1
HbF inducer-1 is a fetal hemoglobin inducer which is orally bioavailable.Formula:C18H19N3O3Color and Shape:SolidMolecular weight:325.36Balanol
CAS:Balanol is an ATP-competitive Protein Kinase C and Protein Kinase A inhibitor.Formula:C28H26N2O10Color and Shape:SolidMolecular weight:550.51RU-0415529
CAS:RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.Formula:C21H29N3O4SColor and Shape:SolidMolecular weight:419.538SGC-BRDVIII-NC
CAS:SGC-BRDVIII-NC (Compound 35) serves as a negative control for the SMARCA2/4 and PB1 bromodomain (BRD) inhibitors. The binding ability of the protein-ligand is completely eliminated in SGC-BRDVIII-NC through the methylation of the phenolic hydroxyl group. This compound is applicable for research in adipogenesis.Formula:C20H27N5O3Color and Shape:SolidMolecular weight:385.46rel-A-395 hydrochloride
CAS:rel-A-395 hydrochloride is the relative configuration of A-395 hydrochloride. A-395 is an antagonist of protein-protein interactions within the polycomb repressive complex 2 (PRC2). It inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 value of 18 nM.Formula:C26H36ClFN4O2SColor and Shape:SolidMolecular weight:523.11QCA570
CAS:QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).Formula:C39H33N7O4SPurity:98%Color and Shape:SolidMolecular weight:695.79XP5
XP5 is an oral HDAC6 inhibitor, potent against cancer cells, including YCC3/7 (IC50=31 nM to 2.31 μM).Formula:C19H25N3O5SColor and Shape:SolidMolecular weight:407.48TD034
CAS:TD034 is a selective, reversible, non-covalent inhibitor of HDAC11, with an IC50 of 5.1 nM and a Ki of 1.5 nM. It does not inhibit other HDACs or sirtuins. TD034 inhibits the desuccinylation of SHMT2 (a substrate of HDAC11) and lowers YAP1 levels by inhibiting HDAC11. TD034 is applicable for lung cancer research.Formula:C45H64N4O6Color and Shape:SolidMolecular weight:757.01PARP14 inhibitor 1
CAS:PARP14 inhibitor1 (compound Q22) is a selective inhibitor of PARP14 with an IC50 of 5.52 nM. It also exhibits anti-inflammatory properties and has a half-life of 182 minutes in mouse liver microsomes. This compound is applicable for atopic dermatitis research.
Formula:C23H27FN4O3Color and Shape:SolidMolecular weight:426.484Ad-JQ1
CAS:Ad-JQ1 (Compound 16) is a Target Protein Ligand-Linker Conjugate incorporating a BRD4 ligand and a PROTAC linker capable of recruiting E3 ligase. It is utilized in the synthesis of PROTACβ-NF-JQ1.Formula:C37H47ClN6O4SColor and Shape:SolidMolecular weight:707.33Galegine hemisulfate
CAS:Galegine hemisulfate, a guanidine derivative, aids in weight reduction in mice. It activates AMPK in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma cells, and HEK293 human renal cell lines. Galegine hemisulfate also exhibits antibacterial activity, with a minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains.Formula:C6H15N3O4SColor and Shape:SolidMolecular weight:225.27PROTAC BRD4 ligand-4
CAS:PROTACBRD4 ligand-4 is a BRD4 ligand used in the synthesis of [PROTACBRD4 Degrader-37].Formula:C17H15NO4Color and Shape:SolidMolecular weight:297.31PROTAC BRD4 Degrader-25
CAS:PROTAC BRD4 Degrader-25 (Compound 1-f), a targeted BRD4 degrader, is utilized in the study of cancer and additional diseases related to bromodomains [1].Formula:C34H30FN9O2SColor and Shape:SolidMolecular weight:647.72CBP/p300-IN-16
CBP/p300-IN-16 (compound 1) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.61 μM) and LK2 H3K27 (IC50: 2.24 μM).Formula:C26H31N3O4Color and Shape:SolidMolecular weight:449.54NI-Pano
NI-Pano (CH-03) is a novel hypoxia-activated KDAC inhibitor capable of O2-dependent release of the compound panobinostat.Formula:C26H28N6O4Color and Shape:SolidMolecular weight:488.54iBRD4-BD1 diTFA
CAS:iBRD4-BD1 diTFA is a selective BRD4 bromodomain inhibitor with an IC50 value of 12 nM. It can be used for research in inflammation and oncology [1].Formula:C33H32F9N5O5Color and Shape:SolidMolecular weight:749.62BRD9 Degrader-2
CAS:BRD9 Degrader-2 (Compound B11), a potent BRD9 degrader (DC50≤1.25nM; Dmax≥75%), is applicable in cancer research.Formula:C40H43F3N6O4SColor and Shape:SolidMolecular weight:760.87Streptonigrin (racemate)
CAS:Streptonigrin: aminoquinone antibiotic; antitumor, antibacterial; blocks β-Catenin/Tcf, cytotoxic; alters hamster chromosomes; (-)-isomer, CAS#3930-19-6.Formula:C25H22N4O8Color and Shape:SolidMolecular weight:506.46O-Desmethyl Midostaurin
CAS:O-Desmethyl Midostaurin is the active Midostaurin metabolite via cytochrome P450 liver enzyme metabolism.Formula:C34H28N4O4Purity:98%Color and Shape:SolidMolecular weight:556.61HDAC6-IN-9
CAS:HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.Formula:C19H16N2O3Purity:98.84%Color and Shape:SolidMolecular weight:320.34Triciferol
CAS:Triciferol is a VDR agonist and HDAC antagonist with 1,25D-like potency, affecting gene targets and tubulin, and shows anti-cancer effects in vitro. IC50=87nM.Formula:C26H39NO4Color and Shape:SolidMolecular weight:429.591TAF1 ligand 1
CAS:TAF1 ligand 1 is a TAF1 ligand. It can serve as a ligand for target proteins (Ligands for Target Protein for PROTAC) in the synthesis of PROTACs targeting TAF1, such as ZS3-046.Formula:C23H23N5O3Color and Shape:SolidMolecular weight:417.46NPC26
CAS:NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.Formula:C19H23N3O5S2Color and Shape:SolidMolecular weight:437.533MS8815
CAS:MS8815 is a selective EZH2 PROTAC degrader with IC50 of 8.6 nM, used in triple-negative breast cancer research.Formula:C65H87N9O8SColor and Shape:SolidMolecular weight:1154.51HDAC-IN-27
HDAC-IN-27 is a potent and orally active inhibitor of HDAC Class I (0.43 nM - 3.01 nM for HDAC1-3).Formula:C20H22N4O2Color and Shape:SolidMolecular weight:350.41CARM1-IN-3 dihydrochloride
CARM1-IN-3 dihydrochloride (17b) is a potent CARM1 inhibitor (IC50: 0.07 μM) with selectivity over CARM3 (IC50 >25 μM).Formula:C24H34Cl2N4O2Color and Shape:SolidMolecular weight:481.46CFT8634
CAS:CFT8634 degrades BRD9, for synovial sarcoma and SMARCB1 tumor research, from patent WO2021178920A1.Formula:C37H45F3N6O5Purity:99.95%Color and Shape:SolidMolecular weight:710.79HDAC6-IN-13
HDAC6-IN-13: potent, selective HDAC6 inhibitor; oral; IC50=0.019μM; targets HDAC1/2/3; crosses blood-brain barrier; anti-inflammatory.Formula:C23H22N4OColor and Shape:SolidMolecular weight:370.45MAT2A-IN-17
CAS:MAT2A-IN-17 is a potent inhibitor of MAT2A, with an IC50 of less than 100 nM. MAT2A-IN-17 is applicable in cancer research.
Formula:C23H18F3N7OColor and Shape:SolidMolecular weight:465.431
