Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2235 products of "Chromatin/Epigenetics"
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UNC2399
CAS:<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Formula:C67H104N10O17SColor and Shape:SolidMolecular weight:1353.68[Ala113]MBP(104-118)
CAS:<p>Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).</p>Formula:C67H104N20O19Purity:98%Color and Shape:SolidMolecular weight:1493.68Dihydrochlamydocin
CAS:<p>Dihydrochlamydocin, an inhibitor of histone deacetylases (HDAC), exhibits potent cytostatic activity against mastocytoma cells.</p>Formula:C28H40N4O6Color and Shape:SolidMolecular weight:528.65HIF1-IN-3
CAS:<p>HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in</p>Formula:C26H24N2O3Purity:99.59%Color and Shape:SolidMolecular weight:412.482-PADQZ hydrochloride
CAS:<p>2-PADQZ hydrochloride shows antiviral activity and targets influenza A virus RNA promoter.</p>Formula:C15H21ClN4O2Purity:99.61%Color and Shape:SolidMolecular weight:324.81CARM1/IKZF3 ligand 1
<p>CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.</p>Formula:C27H35ClN6O3Color and Shape:SolidMolecular weight:527.06MS33
CAS:<p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>Formula:C64H84F3N11O7SColor and Shape:SolidMolecular weight:1208.5MT1
CAS:<p>MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).</p>Formula:C54H66Cl2N10O9S2Color and Shape:SolidMolecular weight:1134.2AB3067
<p>AB3067 is a PROTAC degrader targeting BET protein, efficiently recruiting two distinct E3 ligases, Cereblon and VHL, with strong affinity (demonstrated by IC50 values of 559 nM for VHL and 190 nM for CRBN in vivo HEK293). It degrades BRD2, BRD3, BRD4, and CRBN with DC50 values of 2.1~2.3, 1.6, 15, and 75 nM, respectively. Additionally, AB3067 inhibits the proliferation of RKO cells, with an EC50 of 111 nM. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL and CRBN)</p>Formula:C74H91ClFN11O17S2Color and Shape:SolidMolecular weight:1525.16XF056-132
CAS:<p>XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .</p>Formula:C51H57F4N9O7SColor and Shape:SolidMolecular weight:1016.11PROTAC BRD4 Degrader-9
CAS:<p>PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.</p>Formula:C59H71F2N9O15S4Color and Shape:SolidMolecular weight:1312.5ZXH-3-26
CAS:<p>ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.</p>Formula:C38H37ClN8O7SPurity:98.90% - 98.90%Color and Shape:SolidMolecular weight:785.27PRMT5-IN-12
CAS:<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Formula:C32H40N4O4Color and Shape:SolidMolecular weight:544.696PI3Kα/HDAC6-IN-1
<p>PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.</p>Formula:C27H30F3N7O6S2Purity:98%Color and Shape:SolidMolecular weight:669.7HIV-1 protease-IN-10
<p>HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) and</p>Formula:C23H40O5Purity:98%Color and Shape:SolidMolecular weight:396.56MNN-02-155
CAS:<p>MNN-02-155 is a bivalent molecular glue that can simultaneously interact with both p300/CBP and BCL6. It effectively induces the activation of BCL6-targeted reporter genes and promotes cell death. This compound is used in the research of diffuse large B-cell lymphoma (DLBCL).</p>Formula:C56H68ClF2N15O7Color and Shape:SolidMolecular weight:1136.69XYD198
<p>XYD198 (Compound 14h) is an orally active degrader of CBP/p300. It inhibits the CBP/p300 bromodomain with an IC50 of 213.5 nM and exhibits antitumor activity against acute myeloid leukemia.</p>Formula:C54H49F2N11O7Molecular weight:1001.37845TAT-cyclo-CLLFVY
CAS:<p>Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).</p>Formula:C111H188N42O24S2Purity:98%Color and Shape:SolidMolecular weight:2559.1Sirtuin modulator 5
CAS:<p>Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.</p>Formula:C24H23N3O4Color and Shape:SolidMolecular weight:417.46ZMF-23
<p>ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis and</p>Formula:C22H23Cl2N5O3Purity:98%Color and Shape:SolidMolecular weight:476.36SIRT5 inhibitor 9
CAS:<p>SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.</p>Formula:C24H29ClN8O4SPurity:98.68%Color and Shape:SolidMolecular weight:561.06PROTAC HDAC6 degrader 3
<p>PROTACHDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader of HDAC6, with an IC50 of 686 nM and a DC50 of 171 nM. It enhances the acetylation of α-tubulin. [Pink: ligand for target protein; Blue: ligand for E3ligaseVHL.]</p>Formula:C46H56F2N10O9SColor and Shape:SolidMolecular weight:963.06MZP-54
CAS:<p>MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)</p>Formula:C55H66ClN7O9SPurity:98%Color and Shape:SolidMolecular weight:1036.67N-Desmethyltamoxifen
CAS:<p>N-Desmethyltamoxifen, tamoxifen's main human metabolite, regulates AML cell ceramide metabolism and is a more potent PKC inhibitor than tamoxifen.</p>Formula:C25H27NOPurity:98%Color and Shape:SolidMolecular weight:357.49PROTAC_ERRα
CAS:<p>PROTAC_ERRα is a potent, selective degrader of ERRα, efficiently facilitating its proteasomal degradation.</p>Formula:C46H47F3N6O9S2Color and Shape:SolidMolecular weight:949.03Sirt2-IN-7
<p>Sirt2-IN-7, a selective SIRT2 inhibitor, has IC50 and Ki values of 178.2 nM and 154.3 nM, useful in cancer research.</p>Formula:C22H38Cl2K3N3OSColor and Shape:SolidMolecular weight:831.98RMM23
<p>RMM23 is an inhibitor that targets PfBDP1, exhibiting a Kd of 1.24 μM. In vitro, it shows EC50 values of 18 μM against the 3D7 wild-type strain, 14 μM against the NF54 wild-type strain, and 20 μM against the multidrug-resistant K1 strain during the blood stage.</p>Color and Shape:Odour SolidTNKS-2-IN-2
CAS:<p>TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.</p>Formula:C26H23N3O6Purity:99.45%Color and Shape:SoildMolecular weight:473.48GSK3735967
CAS:<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Formula:C25H31N7OSColor and Shape:SolidMolecular weight:477.62PROTAC BRD4 Degrader-13
CAS:<p>PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.</p>Formula:C68H85F2N11O17P2S2Color and Shape:SolidMolecular weight:1492.55SJ988497
CAS:<p>SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.</p>Formula:C36H36N10O5Color and Shape:SolidMolecular weight:688.74NCT-TFP
CAS:<p>NCT-TFP is PARP probe used to identifying Poly(ADP-ribose) polymerases (PARP) inhibitors[1].</p>Formula:C41H34F4N2O5Color and Shape:SolidMolecular weight:710.71MS479
<p>MS479 is a BRD4 PROTAC degrader that binds with high affinity to BRD4-BD2 and GLP (BRD4-BD2: Kd = 200 nM; GLP: Kd = 306 nM). It effectively reduces the protein levels of BRD4 short isoforms. By directly binding to its substrate GLP, MS479 recruits the E3 ligase SPOP as a bridging protein. Additionally, MS479 can be utilized to inhibit the proliferation of colorectal cancer cells.</p>Color and Shape:Odour SolidM-808
CAS:<p>M-808, a strong covalent Menin-MLL inhibitor, binds tightly with a 2.6 nM IC50.</p>Formula:C45H63FN6O5SColor and Shape:SolidMolecular weight:819.09Uzansertib
CAS:<p>Uzansertib (INCB053914) is a potent pan-PIM kinase inhibitor with low IC50s: 0.24, 30, 0.12 nM for PIM1, 2, 3; hinders hematologic tumor growth.</p>Formula:C26H26F3N5O3Color and Shape:SolidMolecular weight:513.51Delcasertib acetate
<p>Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.</p>Formula:C122H203N45O36S2Purity:98.92%Color and Shape:SolidMolecular weight:2940.33Myelin Basic Protein
CAS:<p>Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.</p>Formula:C60H103N21O17Purity:98%Color and Shape:SolidMolecular weight:1390.59PKC β pseudosubstrate
CAS:<p>Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).</p>Formula:C177H294N62O38S3Purity:98%Color and Shape:SolidMolecular weight:3994.84FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Color and Shape:LiquiddBAZ2
<p>dBAZ2 is a pioneering PROTAC degrader targeting BAZ2A and BAZ2B, with DC50 values of 180 nM for BAZ2A and 250 nM for BAZ2B.</p>Formula:C54H64FN11O5S2Color and Shape:SolidMolecular weight:1030.29Okicenone
CAS:<p>Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.</p>Formula:C15H14O4Color and Shape:SolidMolecular weight:258.27BAY-184
CAS:<p>BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.</p>Formula:C23H20N2O4SPurity:98.87%Color and Shape:SolidMolecular weight:420.48(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS:<p>(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.</p>Formula:C41H46N6O6SColor and Shape:SolidMolecular weight:750.91PRMT5-IN-15
CAS:<p>PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.</p>Formula:C24H23F3N6O2Color and Shape:SolidMolecular weight:484.483PROTAC BRD4-binding moiety 1
CAS:<p>BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.</p>Formula:C23H21N3O2Purity:98%Color and Shape:SolidMolecular weight:371.43HSP70/SIRT2-IN-1
<p>HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.</p>Purity:98%Color and Shape:Odour SolidPKCδ Peptide Substrate
CAS:<p>PKCδ Peptide Substrate is a highly specific substrate for the δ-type of Protein kinase C, composed of a sequence that mirrors murine eEF-1α (422-443) and</p>Formula:C109H191N35O29SColor and Shape:SolidMolecular weight:2487.97Dot1L-IN-9
<p>Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.</p>Color and Shape:Odour SolidPROTAC BET degrader-3
<p>PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.</p>Formula:C53H64N12O9SPurity:98%Color and Shape:SolidMolecular weight:1045.22CPI-268456
CAS:<p>CPI-268456 is a compound which has bioactive.</p>Formula:C20H15Cl2N3O2Color and Shape:SolidMolecular weight:400.26
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