Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Found 2597 products of "Chromatin/Epigenetics"
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AB3067
AB3067 is a PROTAC degrader targeting BET protein, efficiently recruiting two distinct E3 ligases, Cereblon and VHL, with strong affinity (demonstrated by IC50 values of 559 nM for VHL and 190 nM for CRBN in vivo HEK293). It degrades BRD2, BRD3, BRD4, and CRBN with DC50 values of 2.1~2.3, 1.6, 15, and 75 nM, respectively. Additionally, AB3067 inhibits the proliferation of RKO cells, with an EC50 of 111 nM. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL and CRBN)Formula:C74H91ClFN11O17S2Color and Shape:SolidMolecular weight:1525.16PROTAC BET Degrader-1
CAS:PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.Formula:C44H45N11O9Purity:98%Color and Shape:SolidMolecular weight:871.9PROTAC BRD4 Degrader-9
CAS:PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.Formula:C59H71F2N9O15S4Color and Shape:SolidMolecular weight:1312.5ZXH-3-26
CAS:ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.Formula:C38H37ClN8O7SPurity:98.90% - 98.90%Color and Shape:SolidMolecular weight:785.27PRMT5-IN-12
CAS:PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formula:C32H40N4O4Color and Shape:SolidMolecular weight:544.696PI3Kα/HDAC6-IN-1
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.Formula:C27H30F3N7O6S2Purity:98%Color and Shape:SolidMolecular weight:669.7PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Formula:C50H58FN11O6SPurity:98%Color and Shape:SolidMolecular weight:960.13HIV-1 protease-IN-10
HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) andFormula:C23H40O5Purity:98%Color and Shape:SolidMolecular weight:396.56PRO-HD1
PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50Purity:98%Color and Shape:Odour SolidTAT-cyclo-CLLFVY
CAS:Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Formula:C111H188N42O24S2Purity:98%Color and Shape:SolidMolecular weight:2559.1Sirtuin modulator 5
CAS:Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.Formula:C24H23N3O4Color and Shape:SolidMolecular weight:417.46ZMF-23
ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis andFormula:C22H23Cl2N5O3Purity:98%Color and Shape:SolidMolecular weight:476.36[Ala107]MBP(104-118)
CAS:Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).Formula:C67H104N20O19Purity:98%Color and Shape:SolidMolecular weight:1493.68Namoline
CAS:Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.Formula:C10H3ClF3NO4Color and Shape:SolidMolecular weight:293.58TYD-68
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.Color and Shape:Odour SolidCD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Color and Shape:SolidPF-03622905
CAS:PF-03622905: potent ATP-competitive PKC inhibitor, IC50: 5.6-74.1 nM for PKCα/βI/βII/γ/θ, high specificity for PKC.Formula:C24H35N7O3Color and Shape:SolidMolecular weight:469.59Myelin Basic Protein TFA
MHP4-14 TFA, synthetic peptide 4-14 of myelin, selective PKC substrate (Km=7μM), not phosphorylated by other kinases.Formula:C62H104F3N21O19Color and Shape:SolidMolecular weight:1504.61HSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Purity:98%Color and Shape:Odour SolidPROTAC BRD4-binding moiety 1
CAS:BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.Formula:C23H21N3O2Purity:98%Color and Shape:SolidMolecular weight:371.43GSK3735967
CAS:GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formula:C25H31N7OSColor and Shape:SolidMolecular weight:477.62PROTAC BRD4 Degrader-13
CAS:PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.Formula:C68H85F2N11O17P2S2Color and Shape:SolidMolecular weight:1492.55SW2_152F
SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.Formula:C45H62Cl3N7O8Color and Shape:SolidMolecular weight:935.37MZP-54
CAS:MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)Formula:C55H66ClN7O9SPurity:98%Color and Shape:SolidMolecular weight:1036.67A-893
CAS:A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Formula:C29H38Cl2N4O4Color and Shape:SolidMolecular weight:577.54BRD4 degrader AT1
CAS:BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.Formula:C48H58ClN9O5S3Purity:98%Color and Shape:SolidMolecular weight:972.68SJ1008030
CAS:SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.
Formula:C42H43N13O7SColor and Shape:SolidMolecular weight:873.94BETd-246
CAS:BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.Formula:C48H55N11O10Purity:98%Color and Shape:SolidMolecular weight:946.02MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Formula:C15H26Cl2N2OPurity:99.9%Color and Shape:SolidMolecular weight:321.28PKC β pseudosubstrate
CAS:Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).Formula:C177H294N62O38S3Purity:98%Color and Shape:SolidMolecular weight:3994.84α-Hydroxyglutaric Acid
CAS:α-Hydroxyglutaric Acid is a natural product for research related to life sciences. The catalog number is T36624 and the CAS number is 2889-31-8.Formula:C5H8O5Color and Shape:SolidMolecular weight:148.114Okicenone
CAS:Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.
Formula:C15H14O4Color and Shape:SolidMolecular weight:258.27BAY-184
CAS:BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.Formula:C23H20N2O4SPurity:98.87%Color and Shape:SolidMolecular weight:420.48CAY10591
CAS:SIRT1 activated by CAY10591, mimics caloric restriction, extends lifespan, inhibits apoptosis, suppresses TNF-α, and promotes fat mobilization.
Formula:C20H25N5O2Color and Shape:SolidMolecular weight:367.44PROTAC CBP/P300 Degrader-1
CAS:PROTAC CBP/P300 Degrader-1 effectively reduces cancer cell viability by degrading CBP/P300.Formula:C46H53F2N11O6Color and Shape:SolidMolecular weight:893.998PROTAC BRD4 Degrader-32
PROTACBRD4 Degrader-32 (Compound 22) is a potent BRD4 PROTAC degrader with a DC50 of 0.20 nM. It employs a unique carbon-carbon linker to connect the BRD4 binding domain with the CRBN binding domain, forming a ternary complex that induces BRD4 ubiquitination and facilitates proteasomal degradation. PROTACBRD4 Degrader-32 holds promise for research into BRD4-related cancers, such as hematological malignancies.
Formula:C42H42ClN5O5Color and Shape:SolidMolecular weight:731.28745PROTAC BRD9-binding moiety 5
CAS:PROTAC BRD9 binder moiety 5 selectively binds BRD9 with IC50 4.20μM, used in PROTAC synthesis, shows cancer cell antiproliferative activity.Formula:C19H18N6OColor and Shape:SolidMolecular weight:346.39QA-68
QA-68 is a potent BRD9 degrader, inhibits cell growth, and has anti-leukemic properties.Formula:C61H72N10O10S2Color and Shape:SolidMolecular weight:1169.42ZIP
CAS:Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.Formula:C90H154N30O17Purity:98%Color and Shape:SolidMolecular weight:1928.4PROTAC BET degrader-3
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.Formula:C53H64N12O9SPurity:98%Color and Shape:SolidMolecular weight:1045.22PF-04577806
CAS:PF-04577806: potent & selective PKC inhibitor, ATP competitive, blocks PKCα/βI/βII/γ/θ (IC50: 2.4-45.9 nM), may reverse diabetic retinal leakage.Formula:C26H37N7O3Color and Shape:SolidMolecular weight:495.628Lyngbyatoxin A
CAS:Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as "swimmers' itch" in Hawaii.
Formula:C27H39N3O2Color and Shape:SolidMolecular weight:437.62DNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Color and Shape:Odour SolidPumecitinib
CAS:Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.
Formula:C17H20N8O2SPurity:99.94%Color and Shape:SoildMolecular weight:400.46Tyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase relatedColor and Shape:Odour SolidRef: TM-L2200
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireWDR5-MYC-IN-1
WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.Color and Shape:Odour SolidFluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Color and Shape:SolidMalantide
CAS:Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Formula:C72H124N22O21Purity:98%Color and Shape:SolidMolecular weight:1633.89SJ1008030 formic
SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with anFormula:C43H45N13O9SPurity:98%Color and Shape:SolidMolecular weight:919.96KDM5-C49 hydrochloride
KDM5-C49 hydrochloride selectively inhibits KDM5A/B/C demethylases (IC50: 40/160/100 nM) for cancer research.Formula:C15H25ClN4O3Color and Shape:SolidMolecular weight:344.84
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