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Chromatin/Epigenetics

Chromatin/Epigenetics

Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.

Subcategories of "Chromatin/Epigenetics"

Found 2235 products of "Chromatin/Epigenetics"

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  • PROTAC BRD4 Degrader-15
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    PROTAC BRD4 Degrader-15

    CAS:
    <p>PROTAC BRD4 Degrader-15 targets von Hippel-Lindau and BRD4 with IC50s 7.2/8.1 nM and degrades BRD4 in cancer cells.</p>
    Formula:C57H62F2N10O10S2
    Color and Shape:Solid
    Molecular weight:1149.3

    Ref: TM-T40074

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    BI01826025

    <p>BI01826025 (pArg-JQ1), a BRDT BD1 bromodomain PROTAC degrader, tests ClpC2's effect on ClpC1P1P2 protease.</p>
    Formula:C31H42ClN10O7PS
    Color and Shape:Solid
    Molecular weight:765.22

    Ref: TM-T75170

  • N-Desmethyltamoxifen
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    N-Desmethyltamoxifen

    CAS:
    <p>N-Desmethyltamoxifen, tamoxifen's main human metabolite, regulates AML cell ceramide metabolism and is a more potent PKC inhibitor than tamoxifen.</p>
    Formula:C25H27NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:357.49

    Ref: TM-T12148L

  • R8-T198wt
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    R8-T198wt

    CAS:
    <p>Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.</p>
    Formula:C111H211N59O26S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2820.33

    Ref: TM-TP2128

  • CPI-1328
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    CPI-1328

    CAS:
    <p>CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.</p>
    Formula:C28H36ClN3O4S
    Color and Shape:Solid
    Molecular weight:546.12

    Ref: TM-T39971

  • HDAC1/2-IN-3
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    HDAC1/2-IN-3

    CAS:
    <p>HDAC1/2-IN-3 is an inhibitor of both HDAC1 and HDAC2, demonstrating IC50 values of 0-5 nM and 5-10 nM, respectively.</p>
    Formula:C24H25N5OS
    Color and Shape:Solid
    Molecular weight:431.56

    Ref: TM-T39567

  • Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
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    Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH

    CAS:
    <p>Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].</p>
    Formula:C34H43N3O7
    Color and Shape:Solid
    Molecular weight:605.72

    Ref: TM-T74554

  • Pep2m, myristoylated
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    Pep2m, myristoylated

    CAS:
    <p>Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.</p>
    Formula:C63H118N18O14S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1383.8

    Ref: TM-TP1945

  • (R)-SKBG-1
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    (R)-SKBG-1

    CAS:
    <p>(R)-SKBG-1 is an inhibitor of the RNA-binding protein NONO, effectively downregulating androgen receptor expression by targeting both AR-FL mRNA and AR-V7 mRNA</p>
    Formula:C22H26ClN3O6S
    Purity:97.25%
    Color and Shape:Solid
    Molecular weight:495.98

    Ref: TM-T79156

  • SGC3027
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    SGC3027

    <p>SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.</p>
    Formula:C41H47ClN6O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:787.37

    Ref: TM-T12887

  • AUR1545
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    AUR1545

    CAS:
    <p>AUR1545 is a selective KAT2A/KAT2B degradator exhibiting inhibitory activity against cancer models including AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.</p>
    Formula:C41H50BrN9O5
    Purity:98.84%
    Color and Shape:Solid
    Molecular weight:828.8

    Ref: TM-T205224

  • Protein Kinase C (19-31)
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    Protein Kinase C (19-31)

    CAS:
    <p>Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.</p>
    Formula:C67H118N26O16
    Purity:98%
    Color and Shape:Lyophilized Powder
    Molecular weight:1543.82

    Ref: TM-TP1053

  • Bisindolylmaleimide XI hydrochloride
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    Bisindolylmaleimide XI hydrochloride

    CAS:
    <p>Bisindolylmaleimide XI hydrochloride is an orally active PKC inhibitor with inhibitory effects on PKCα, PKCβI, PKCβII, and PKCγ (IC50s of 9 nM, 28 nM, 31 nM, 37</p>
    Formula:C28H29ClN4O2
    Color and Shape:Solid
    Molecular weight:489.01

    Ref: TM-T36228

  • AS2553627
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    AS2553627

    CAS:
    <p>AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.</p>
    Formula:C18H19N5O
    Color and Shape:Solid
    Molecular weight:321.38

    Ref: TM-T26664

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    Fluorescein-NAD+

    <p>Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.</p>
    Color and Shape:Solid

    Ref: TM-T36304

  • SJ10542
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    SJ10542

    CAS:
    <p>SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.</p>
    Formula:C41H46N12O5S
    Color and Shape:Solid
    Molecular weight:818.95

    Ref: TM-T74429

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    DAO-dBET1

    <p>DAO-dBET1, a dual-action PROTAC incorporating the PROTAC degrader dBET1, effectively serves as a potent BRD4 degrader and exhibits a DC50 value of 277 nM in the presence of CoCl2. Additionally, DAO-dBET1 inhibits hypoxia and Cath-L activation with an IC50 value of 281 nM.</p>
    Color and Shape:Odour Solid

    Ref: TM-T206694

  • PROTAC BRD4-binding moiety 1
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    PROTAC BRD4-binding moiety 1

    CAS:
    <p>BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.</p>
    Formula:C23H21N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:371.43

    Ref: TM-T18599

  • PROTAC SMARCA2/4-degrader-28
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    PROTAC SMARCA2/4-degrader-28

    CAS:
    <p>PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.</p>
    Formula:C54H68ClN9O11S2
    Color and Shape:Solid
    Molecular weight:1118.75

    Ref: TM-T200190

  • PARP1-IN-6
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    PARP1-IN-6

    CAS:
    <p>PARP1-IN-6, a dual-function inhibitor, targets both tubulin and PARP-1, demonstrating inhibitory concentration (IC50) values of 0.94 μM for tubulin and 0.48 μM</p>
    Formula:C16H11FN2O
    Color and Shape:Solid
    Molecular weight:266.27

    Ref: TM-T39139