DNA Alkylation
DNA alkylation involves the addition of alkyl groups to the DNA molecule, leading to the formation of lesions that can interfere with DNA replication and transcription. DNA alkylating agents are commonly used in cancer chemotherapy to induce DNA damage in rapidly dividing cells. However, cells have mechanisms to repair these lesions, and inhibitors of DNA alkylation repair pathways can enhance the efficacy of alkylating agents. At CymitQuimica, we offer a selection of high-quality DNA alkylation reagents and inhibitors to support your research in DNA damage, repair mechanisms, and cancer therapy.
Found 14 products of "DNA Alkylation"
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Methyl methanesulfonate
CAS:Methyl methanesulfonate alkylates adenine and guanine, causing base mismatches and replication issues.Formula:C2H6O3SPurity:99.69%Color and Shape:SolidMolecular weight:110.13Melphalan
CAS:Melphalan is an orally bioavailable DNA alkylating agent exhibiting antitumour activity, commonly employed in cancer chemotherapy.Formula:C13H18Cl2N2O2Molecular weight:305.21Phosphoramide mustard
CAS:Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.Formula:C4H11Cl2N2O2PPurity:93.00%Color and Shape:SolidMolecular weight:221.02Methyl methanesulfonate (Standard)
CAS:Methyl methanesulfonate (Standard) is a standard material used in the analysis of methyl methanesulfonate, typically referenced in its research and analysis.Formula:C2H6O3SColor and Shape:LiquidMolecular weight:110.13Phosphoramide mustard cyclohexanamine
CAS:Phosphoramide mustard cyclohexanamine is active metabolite of cyclophosphamide, an alkylating agent that cross-links DNA strands,causes cell death, antitumor.Formula:C10H24Cl2N3O2PPurity:95%Color and Shape:SolidMolecular weight:320.2GNE-3511
CAS:GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.Formula:C23H26F2N6OPurity:98.3% - 99.51%Color and Shape:SolidMolecular weight:440.49Palifosfamide
CAS:Palifosfamide lysine (ZIO-201) stable, effective vs. sarcomas in vitro. IC50: 2.25-6.75 μM, except OS222 at 31.5 μM.Formula:C4H11Cl2N2O2PPurity:99.72%Color and Shape:SolidMolecular weight:221.02Tretazicar
CAS:CB1954, an anticancer prodrug, turns into a potent alkylating agent when activated by NQO2 and EP-0152R.Formula:C9H8N4O5Purity:99.41% - 99.7%Color and Shape:SolidMolecular weight:252.18VAL-083
CAS:VAL-083 (Dianhydrogalactitol) is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.Formula:C6H10O4Purity:97.94%Color and Shape:SolidMolecular weight:146.14Miriplatin hydrate
CAS:Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).Formula:C34H70N2O5PtPurity:99.6%Color and Shape:SolidMolecular weight:782.01DN-1289
<p>DN-1289: oral, BBB-penetrating, selectively inhibits DLK (IC50=17nM) & LZK (IC50=40nM), blocks p-c-Jun in mouse optic nerve crush.</p>Formula:C18H19F4N7O2Purity:98.56%Color and Shape:SolidMolecular weight:441.38GNE-8505
CAS:GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).Formula:C21H24F3N5OColor and Shape:SolidMolecular weight:419.44IACS-52825
CAS:IACS-52825 is a DLK inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model and can be used to study neurological disorders.Formula:C16H13F7N4O2Purity:99.77%Color and Shape:SolidMolecular weight:426.29DLK-IN-1
CAS:DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.Formula:C20H24F3N5O2Color and Shape:SolidMolecular weight:423.43
