DNA Alkylation
DNA alkylation involves the addition of alkyl groups to the DNA molecule, leading to the formation of lesions that can interfere with DNA replication and transcription. DNA alkylating agents are commonly used in cancer chemotherapy to induce DNA damage in rapidly dividing cells. However, cells have mechanisms to repair these lesions, and inhibitors of DNA alkylation repair pathways can enhance the efficacy of alkylating agents. At CymitQuimica, we offer a selection of high-quality DNA alkylation reagents and inhibitors to support your research in DNA damage, repair mechanisms, and cancer therapy.
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Methyl methanesulfonate
CAS:66-27-3
Methyl methanesulfonate alkylates adenine and guanine, causing base mismatches and replication issues.
Formula:
C2H6O3S
Purity:
≥98%
Color and Shape:
Liquid
Molecular weight:
110.13
Ref: TM-T9985
| 10g | 34.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
Phosphoramide mustard
CAS:10159-53-2
Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that …
Formula:
C4H11Cl2N2O2P
Purity:
93.00%
Color and Shape:
Liquid
Molecular weight:
221.02
Ref: TM-T38410
| 1mg | 277.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
GNE-3511
CAS:1496581-76-0
GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
Formula:
C23H26F2N6O
Purity:
98.64% - 99.37%
Color and Shape:
Solid
Molecular weight:
440.49
Ref: TM-T3707
| 10mg | 50.00 € | ||
| 25mg | 78.00 € | ||
| 50mg | 113.00 € | ||
| 100mg | 182.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Duocarmycin TM
CAS:157922-77-5
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
Formula:
C25H23ClN2O5
Purity:
99.15% - 99.15%
Color and Shape:
Solid
Molecular weight:
466.91
Ref: TM-T11120
| 1mg | 152.00 € | ||
| 5mg | 368.00 € | ||
| 10mg | 550.00 € | ||
| 25mg | 878.00 € | ||
| 50mg | 1,188.00 € | ||
| 1mL*10mM (DMSO) | 393.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Lobaplatin
CAS:135558-11-1
Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe.
Formula:
C9H18N2O3Pt
Purity:
98.00%
Color and Shape:
Solid
Molecular weight:
397.33
Ref: TM-T15771
| 1mg | 96.00 € | ||
| 5mg | 260.00 € | ||
| 10mg | 426.00 € | ||
| 25mg | 700.00 € | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 13 Jan 2025
CEP-40125
CAS:1456608-94-8
CEP-40125 (RXDX-107) is a DNA alkylating agent for the study of advanced solid tumors.
Formula:
C28H45Cl2N3O2
Purity:
98.05%
Color and Shape:
Solid
Molecular weight:
526.58
Ref: TM-T26978
| 1mg | 278.00 € | ||
| 5mg | 685.00 € | ||
| 10mg | 936.00 € | ||
| 25mg | 1,442.00 € | ||
| 50mg | 1,878.00 € | ||
| 100mg | 2,371.00 € |
Estimated delivery in United States, on Monday 24 Feb 2025
Miriplatin hydrate
CAS:250159-48-9
Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows …
Formula:
C34H70N2O5Pt
Purity:
99.6%
Color and Shape:
Solid
Molecular weight:
782.01
Ref: TM-T21297
| 2mg | 44.00 € | ||
| 5mg | 65.00 € | ||
| 10mg | 84.00 € | ||
| 25mg | 145.00 € | ||
| 50mg | 215.00 € | ||
| 100mg | 311.00 € | ||
| 200mg | 447.00 € |
Estimated delivery in United States, on Monday 24 Feb 2025
DN-1289
DN-1289: oral, BBB-penetrating, selectively inhibits DLK (IC50=17nM) & LZK (IC50=40nM), blocks p-c-Jun in mouse optic …
Formula:
C18H19F4N7O2
Purity:
100%
Color and Shape:
Liquid
Molecular weight:
441.38
Ref: TM-T73457
| 1mg | 327.00 € | ||
| 5mg | 901.00 € | ||
| 10mg | 1,121.00 € | ||
| 25mg | 1,486.00 € | ||
| 50mg | 1,838.00 € | ||
| 100mg | 2,321.00 € |
Estimated delivery in United States, on Monday 24 Feb 2025
IACS-52825
CAS:2640376-72-1
IACS-52825 is a DLK inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model …
Formula:
C16H13F7N4O2
Purity:
99.78%
Color and Shape:
Liquid
Molecular weight:
426.29
Ref: TM-T79303
| 1mg | 181.00 € | ||
| 5mg | 449.00 € | ||
| 10mg | 642.00 € | ||
| 25mg | 1,002.00 € | ||
| 50mg | 1,383.00 € | ||
| 100mg | 1,828.00 € |
Estimated delivery in United States, on Monday 10 Mar 2025
Duocarmycin Analog
CAS:372954-15-9
Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an …
Formula:
C34H31ClN4O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
611.09
Ref: TM-T19300
| 25mg | 1,967.00 € | ||
| 50mg | 2,598.00 € | ||
| 100mg | 3,458.00 € |
Estimated delivery in United States, on Monday 10 Mar 2025
GNE-8505
CAS:1620573-48-9
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
Formula:
C21H24F3N5O
Color and Shape:
Solid
Molecular weight:
419.44
Ref: TM-T11440
| 25mg | 854.00 € | ||
| 50mg | 1,105.00 € | ||
| 100mg | 1,676.00 € |
Estimated delivery in United States, on Monday 10 Mar 2025
DLK-IN-1
CAS:1620574-24-4
DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained …
Formula:
C20H24F3N5O2
Color and Shape:
Solid
Molecular weight:
423.43
Ref: TM-T11056
| 5mg | 490.00 € | ||
| 25mg | 1,623.00 € | ||
| 50mg | 2,134.00 € | ||
| 100mg | 3,061.00 € |
Estimated delivery in United States, on Monday 7 Apr 2025
Seco-Duocarmycin SA
CAS:144667-38-9
Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
Formula:
C25H24ClN3O7
Purity:
98%
Color and Shape:
Solid
Molecular weight:
513.93
Ref: TM-T12813L
| 25mg | 2,106.00 € | ||
| 50mg | 2,785.00 € | ||
| 100mg | 3,739.00 € |
Estimated delivery in United States, on Monday 7 Apr 2025
