CymitQuimica logo
DNA Alkylation

DNA Alkylation

DNA alkylation involves the addition of alkyl groups to the DNA molecule, leading to the formation of lesions that can interfere with DNA replication and transcription. DNA alkylating agents are commonly used in cancer chemotherapy to induce DNA damage in rapidly dividing cells. However, cells have mechanisms to repair these lesions, and inhibitors of DNA alkylation repair pathways can enhance the efficacy of alkylating agents. At CymitQuimica, we offer a selection of high-quality DNA alkylation reagents and inhibitors to support your research in DNA damage, repair mechanisms, and cancer therapy.

Found 11 products of "DNA Alkylation"

Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
  • Methyl methanesulfonate
    Targetmol
    + Info

    Methyl methanesulfonate

    CAS:
    <p>Methyl methanesulfonate alkylates adenine and guanine, causing base mismatches and replication issues.</p>
    Formula:C2H6O3S
    Purity:99.69%
    Color and Shape:Solid
    Molecular weight:110.13

    Ref: TM-T9985

  • Phosphoramide mustard
    Targetmol
    + Info

    Phosphoramide mustard

    CAS:
    <p>Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.</p>
    Formula:C4H11Cl2N2O2P
    Purity:93.00%
    Color and Shape:Solid
    Molecular weight:221.02

    Ref: TM-T38410

  • Methyl methanesulfonate (Standard)
    Targetmol
    + Info

    Methyl methanesulfonate (Standard)

    CAS:
    <p>Methyl methanesulfonate (Standard) is a standard material used in the analysis of methyl methanesulfonate, typically referenced in its research and analysis.</p>
    Formula:C2H6O3S
    Color and Shape:Solid
    Molecular weight:110.13

    Ref: TM-T9985BP

  • Phosphoramide mustard cyclohexanamine
    Targetmol
    + Info

    Phosphoramide mustard cyclohexanamine

    CAS:
    <p>Phosphoramide mustard cyclohexanamine is active metabolite of cyclophosphamide, an alkylating agent that cross-links DNA strands,causes cell death, antitumor.</p>
    Formula:C10H24Cl2N3O2P
    Purity:95%
    Color and Shape:Solid
    Molecular weight:320.2

    Ref: TM-T36701

  • GNE-3511
    Targetmol
    + Info

    GNE-3511

    CAS:
    GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
    Formula:C23H26F2N6O
    Purity:98.3% - 99.51%
    Color and Shape:Solid
    Molecular weight:440.49

    Ref: TM-T3707

  • Palifosfamide
    Targetmol
    + Info

    Palifosfamide

    CAS:
    <p>Palifosfamide lysine (ZIO-201) stable, effective vs. sarcomas in vitro. IC50: 2.25-6.75 μM, except OS222 at 31.5 μM.</p>
    Formula:C4H11Cl2N2O2P
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:221.02

    Ref: TM-T4350

  • Miriplatin hydrate
    Targetmol
    + Info

    Miriplatin hydrate

    CAS:
    Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).
    Formula:C34H70N2O5Pt
    Purity:99.6%
    Color and Shape:Solid
    Molecular weight:782.01

    Ref: TM-T21297

  • DN-1289
    Targetmol
    + Info

    DN-1289

    <p>DN-1289: oral, BBB-penetrating, selectively inhibits DLK (IC50=17nM) &amp; LZK (IC50=40nM), blocks p-c-Jun in mouse optic nerve crush.</p>
    Formula:C18H19F4N7O2
    Purity:98.56%
    Color and Shape:Solid
    Molecular weight:441.38

    Ref: TM-T73457

  • GNE-8505
    Targetmol
    + Info

    GNE-8505

    CAS:
    <p>GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).</p>
    Formula:C21H24F3N5O
    Color and Shape:Solid
    Molecular weight:419.44

    Ref: TM-T11440

  • IACS-52825
    Targetmol
    + Info

    IACS-52825

    CAS:
    <p>IACS-52825 is a DLK inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model and can be used to study neurological disorders.</p>
    Formula:C16H13F7N4O2
    Purity:99.77%
    Color and Shape:Solid
    Molecular weight:426.29

    Ref: TM-T79303

  • DLK-IN-1
    Targetmol
    + Info

    DLK-IN-1

    CAS:
    DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.
    Formula:C20H24F3N5O2
    Color and Shape:Solid
    Molecular weight:423.43

    Ref: TM-T11056