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Androgen Receptor

Androgen Receptor

The androgen receptor (AR) is a nuclear hormone receptor that is activated by binding to androgens, such as testosterone and dihydrotestosterone. This receptor plays a crucial role in the development and maintenance of male characteristics, as well as in the regulation of several physiological processes, including muscle growth, libido, and bone density. Androgen receptor inhibitors are widely studied in the context of prostate cancer, where AR signaling is often upregulated. At CymitQuimica, we offer a range of high-quality androgen receptor modulators to support your research in endocrinology, cancer biology, and hormone regulation.

Found 207 products of "Androgen Receptor"

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  • JNJ-1250132
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    JNJ-1250132

    CAS:
    <p>JNJ-1250132 is a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro.</p>
    Formula:C33H41NO4
    Color and Shape:Solid
    Molecular weight:515.68

    Ref: TM-T27662

  • ERβ agonist-1
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    ERβ agonist-1

    CAS:
    <p>ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.</p>
    Formula:C25H36O2
    Color and Shape:Solid
    Molecular weight:368.55

    Ref: TM-T207458

  • EN1441
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    EN1441

    CAS:
    <p>EN1441 is a covalent degrader that targets the androgen receptor (AR) with an EC50 value of 4.2 μM, as well as its truncated variant AR-V7. It selectively and effectively degrades AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 holds potential for research into androgen-independent prostate cancer.</p>
    Formula:C13H13ClN2O2
    Color and Shape:Solid
    Molecular weight:264.708

    Ref: TM-T206982

  • AR antagonist 11
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    AR antagonist 11

    CAS:
    <p>AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM). Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM). This compound is applicable in prostate cancer (PCa) research.</p>
    Formula:C20H17ClN2O
    Color and Shape:Solid
    Molecular weight:336.815

    Ref: TM-T206875

  • Pentomone
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    Pentomone

    CAS:
    <p>Pentomone (LY-113935) is an anti-androgen compound that acts as a prostate growth inhibitor.</p>
    Formula:C24H26O5
    Color and Shape:Solid
    Molecular weight:394.46

    Ref: TM-T201000

  • PF-998425
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    PF-998425

    CAS:
    <p>non-steroidal androgen receptor (AR) antagonist</p>
    Formula:C14H14F3NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:269.26

    Ref: TM-T23141

    25mg
    Discontinued
    Discontinued product
  • YK11
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    YK11

    CAS:
    <p>YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM, with osteogenic activity.</p>
    Formula:C25H34O6
    Purity:98.91%
    Color and Shape:Soild
    Molecular weight:430.53

    Ref: TM-T7358

    1ml
    Discontinued
    Discontinued product