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NF-κB

NF-κB

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.

Found 445 products of "NF-κB"

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  • DMX-129
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    DMX-129

    CAS:
    <p>DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].</p>
    Formula:C19H17FN8
    Color and Shape:Solid
    Molecular weight:376.39

    Ref: TM-T61550

  • TNF-α-IN-18
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    TNF-α-IN-18

    CAS:
    <p>TNF-α-IN-18 is a small molecule TNF-α inhibitor that blocks NF-κB translocation, alleviates sepsis in models, and protects against rheumatoid arthritis in mice.</p>
    Formula:C16H7ClF2O4
    Purity:99.77%
    Color and Shape:Solid
    Molecular weight:336.67

    Ref: TM-T88696

  • Anti-inflammatory agent 21
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    Anti-inflammatory agent 21

    CAS:
    <p>Compound 9o: orally active, low-toxicity anti-inflammatory; inhibits NO (IC50: 0.76 μM), blocks NF-κB/MAPK, reduces arthritis symptoms.</p>
    Formula:C24H21FO6
    Color and Shape:Solid
    Molecular weight:424.42

    Ref: TM-T62284

  • HSR1304
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    HSR1304

    CAS:
    <p>HSR1304 (5d) inhibits NFκB, key in diseases like cancer, offering research potential.</p>
    Formula:C24H21ClN2O3
    Color and Shape:Solid
    Molecular weight:420.89

    Ref: TM-T62239

  • Xanthine oxidase-IN-6
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    Xanthine oxidase-IN-6

    <p>Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.</p>
    Formula:C29H34N2O15
    Color and Shape:Solid
    Molecular weight:650.58

    Ref: TM-T72409

  • NF-κB/PON1-IN-1
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    NF-κB/PON1-IN-1

    CAS:
    <p>NF-κB/PON1-IN-1 (Compound 16) is an NF-κB/PON1 pathway inhibitor with antioxidant activity (IC50: 45.76 μM) and hepatoprotective activity.</p>
    Formula:C20H16N6O4S2
    Color and Shape:Solid
    Molecular weight:468.51

    Ref: TM-T63009

  • RI-962
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    RI-962

    CAS:
    <p>RI-962 is a potent and selective inhibitor of RIPK1 that protects cells from necrotic apoptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation.</p>
    Formula:C28H28N6O2
    Purity:99.39%
    Color and Shape:Soild
    Molecular weight:480.56

    Ref: TM-T73493

  • TRAF-STOP inhibitor 6877002
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    TRAF-STOP inhibitor 6877002

    CAS:
    <p>TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.</p>
    Formula:C17H17NO
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:251.32

    Ref: TM-T17157

  • Bay 65-1942 free base
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    Bay 65-1942 free base

    CAS:
    <p>Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.</p>
    Formula:C22H25N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:395.45

    Ref: TM-T10472L

  • Asperbisabolane L
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    Asperbisabolane L

    <p>Asperbisabolane L, a sesquiterpenoid, combats inflammation by blocking NF-κB signaling and NO in BV-2 cells.</p>
    Formula:C12H14O3
    Color and Shape:Solid
    Molecular weight:206.24

    Ref: TM-T72646

  • TBK1/IKKε-IN-4
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    TBK1/IKKε-IN-4

    CAS:
    <p>TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM</p>
    Formula:C28H35N7O4
    Color and Shape:Solid
    Molecular weight:533.62

    Ref: TM-T38263

  • PHA-408
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    PHA-408

    CAS:
    <p>PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.</p>
    Formula:C29H27ClFN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:560.02

    Ref: TM-T24629

  • IMD-catechol
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    IMD-catechol

    CAS:
    <p>IMD-catechol: an imidazoquinolinone-based dimer with NF-κB activity; improves CT26 cancer treatment, low toxicity.</p>
    Formula:C31H34N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:538.64

    Ref: TM-T72927

  • CymitQuimica logo
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    NF-κB-IN-8

    CAS:
    <p>NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.</p>
    Formula:C24H21N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:399.44

    Ref: TM-T74799

  • CAY10575
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    CAY10575

    CAS:
    <p>CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.</p>
    Formula:C22H21N3O6S2
    Color and Shape:Solid
    Molecular weight:487.55

    Ref: TM-T26957

  • IMD-biphenylA
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    IMD-biphenylA

    CAS:
    <p>IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immune</p>
    Formula:C35H33N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:555.67

    Ref: TM-T72869

  • NF-κB-IN-11
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    NF-κB-IN-11

    CAS:
    <p>NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.</p>
    Formula:C19H18O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:326.34

    Ref: TM-T79671

  • HE 3286
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    HE 3286

    CAS:
    <p>Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.</p>
    Formula:C21H30O3
    Color and Shape:Solid
    Molecular weight:330.46

    Ref: TM-T29013

  • SP-100030
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    SP-100030

    CAS:
    <p>SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.</p>
    Formula:C14H5ClF9N3O
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:437.65

    Ref: TM-T24816

  • Zabedosertib
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    Zabedosertib

    CAS:
    <p>Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.</p>
    Formula:C20H21F3N4O4S
    Purity:98.54%
    Color and Shape:Solid
    Molecular weight:470.47

    Ref: TM-T37076