NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Found 445 products of "NF-κB"
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Edasalonexent
CAS:<p>Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.</p>Formula:C31H42N2O3Purity:99.13% - >99.99%Color and Shape:SolidMolecular weight:490.68IMD-ferulic
<p>IMD-ferulic, a compound that forms covalent bonds, acts as an NF-κB modulator, enhancing the adjuvanticity of small molecule immune potentiators.</p>Formula:C36H41N7O4Color and Shape:SolidMolecular weight:635.76Ro 106-9920
CAS:<p>Inhibitor of NF-κB activation</p>Formula:C10H7N5OSPurity:98%Color and Shape:SolidMolecular weight:245.26Bay 65-1942 hydrochloride
CAS:<p>Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.</p>Formula:C22H26ClN3O4Color and Shape:SolidMolecular weight:431.91HPN-01
CAS:<p>HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.</p>Formula:C19H16ClN3O3SPurity:98.07% - 98.17%Color and Shape:SolidMolecular weight:401.87RIP2 Kinase Inhibitor 3
CAS:<p>RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.</p>Formula:C19H24N4O3SPurity:99.32% - 99.52%Color and Shape:SolidMolecular weight:388.48NF-κB-IN-2
CAS:<p>NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.</p>Formula:C15H18O3Color and Shape:SolidMolecular weight:246.3Gue1654
CAS:<p>Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.</p>Formula:C23H17N3OS3Purity:98.02% - 98.04%Color and Shape:SolidMolecular weight:447.6GSK319347A
CAS:<p>GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.</p>Formula:C22H19N3O5S2Purity:98.42%Color and Shape:SolidMolecular weight:469.53IKKβ-IN-1
CAS:<p>IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).</p>Formula:C31H30N4O4SColor and Shape:SolidMolecular weight:554.66DMX-129
CAS:<p>DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].</p>Formula:C19H17FN8Color and Shape:SolidMolecular weight:376.39TNF-α-IN-18
CAS:<p>TNF-α-IN-18 is a small molecule TNF-α inhibitor that blocks NF-κB translocation, alleviates sepsis in models, and protects against rheumatoid arthritis in mice.</p>Formula:C16H7ClF2O4Purity:99.77%Color and Shape:SolidMolecular weight:336.67Anti-inflammatory agent 21
CAS:<p>Compound 9o: orally active, low-toxicity anti-inflammatory; inhibits NO (IC50: 0.76 μM), blocks NF-κB/MAPK, reduces arthritis symptoms.</p>Formula:C24H21FO6Color and Shape:SolidMolecular weight:424.42HSR1304
CAS:<p>HSR1304 (5d) inhibits NFκB, key in diseases like cancer, offering research potential.</p>Formula:C24H21ClN2O3Color and Shape:SolidMolecular weight:420.89Xanthine oxidase-IN-6
<p>Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.</p>Formula:C29H34N2O15Color and Shape:SolidMolecular weight:650.58NF-κB/PON1-IN-1
CAS:<p>NF-κB/PON1-IN-1 (Compound 16) is an NF-κB/PON1 pathway inhibitor with antioxidant activity (IC50: 45.76 μM) and hepatoprotective activity.</p>Formula:C20H16N6O4S2Color and Shape:SolidMolecular weight:468.51RI-962
CAS:<p>RI-962 is a potent and selective inhibitor of RIPK1 that protects cells from necrotic apoptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation.</p>Formula:C28H28N6O2Purity:99.39%Color and Shape:SoildMolecular weight:480.56TRAF-STOP inhibitor 6877002
CAS:<p>TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.</p>Formula:C17H17NOPurity:99.76%Color and Shape:SolidMolecular weight:251.32Bay 65-1942 free base
CAS:<p>Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.</p>Formula:C22H25N3O4Purity:98%Color and Shape:SolidMolecular weight:395.45Asperbisabolane L
<p>Asperbisabolane L, a sesquiterpenoid, combats inflammation by blocking NF-κB signaling and NO in BV-2 cells.</p>Formula:C12H14O3Color and Shape:SolidMolecular weight:206.24TBK1/IKKε-IN-4
CAS:<p>TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM</p>Formula:C28H35N7O4Color and Shape:SolidMolecular weight:533.62PHA-408
CAS:<p>PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.</p>Formula:C29H27ClFN7O2Purity:98%Color and Shape:SolidMolecular weight:560.02IMD-catechol
CAS:<p>IMD-catechol: an imidazoquinolinone-based dimer with NF-κB activity; improves CT26 cancer treatment, low toxicity.</p>Formula:C31H34N6O3Purity:98%Color and Shape:SolidMolecular weight:538.64NF-κB-IN-8
CAS:<p>NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.</p>Formula:C24H21N3O3Purity:98%Color and Shape:SolidMolecular weight:399.44CAY10575
CAS:<p>CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.</p>Formula:C22H21N3O6S2Color and Shape:SolidMolecular weight:487.55IMD-biphenylA
CAS:<p>IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immune</p>Formula:C35H33N5O2Purity:98%Color and Shape:SolidMolecular weight:555.67NF-κB-IN-11
CAS:<p>NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.</p>Formula:C19H18O5Purity:98%Color and Shape:SolidMolecular weight:326.34HE 3286
CAS:<p>Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.</p>Formula:C21H30O3Color and Shape:SolidMolecular weight:330.46SP-100030
CAS:<p>SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.</p>Formula:C14H5ClF9N3OPurity:99.79%Color and Shape:SolidMolecular weight:437.65Zabedosertib
CAS:<p>Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.</p>Formula:C20H21F3N4O4SPurity:98.54%Color and Shape:SolidMolecular weight:470.47GSK2983559 free acid
CAS:<p>GSK2983559 free acid selectively inhibits RIP2, reducing inflammatory cytokines in human bowel disease.</p>Formula:C21H23N4O7PS2Purity:97.8700% - 98.61%Color and Shape:SolidMolecular weight:538.53B022
CAS:<p>B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.</p>Formula:C19H16ClN5OSPurity:99.74%Color and Shape:SolidMolecular weight:397.88NFATc1-IN-1
CAS:<p>NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.</p>Formula:C13H8F2INO2Purity:99.64%Color and Shape:SolidMolecular weight:375.11Zharp2-1
CAS:<p>Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).</p>Formula:C19H18N3O2PSPurity:99.41%Color and Shape:SolidMolecular weight:383.4RIPK1-IN-9
CAS:<p>RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).</p>Formula:C26H25FN6O2Purity:99.85%Color and Shape:SolidMolecular weight:472.51HS271
CAS:<p>HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM).</p>Formula:C21H24F3N5O2Purity:98.79%Color and Shape:SolidMolecular weight:435.44IRAK4-IN-20
CAS:<p>IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).</p>Formula:C22H25F3N4O3Purity:98.09%Color and Shape:SolidMolecular weight:450.45GSK840
CAS:<p>GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase</p>Formula:C21H23N3O3Purity:99.7%Color and Shape:SolidMolecular weight:365.43PF-184
<p>PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.</p>Formula:C32H32ClFN6O4Color and Shape:SolidMolecular weight:619.09WEHI-345
CAS:<p>WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.</p>Formula:C22H23N7OPurity:>99.99%Color and Shape:SolidMolecular weight:401.46RIPK1-IN-16
CAS:<p>RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.</p>Formula:C20H19N5O2SPurity:98%Color and Shape:SolidMolecular weight:393.46Ginsenoside Rk1
CAS:<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formula:C42H70O12Purity:98.46% - 99.13%Color and Shape:SolidMolecular weight:767PF 184
CAS:<p>IKKβ inhibitor</p>Formula:C32H32ClFN6O4Purity:98%Color and Shape:SolidMolecular weight:619.09RIP1 kinase inhibitor 4
CAS:<p>RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].</p>Formula:C23H23N5Purity:98%Color and Shape:SolidMolecular weight:369.46IMD-biphenylC
CAS:<p>IMD-biphenylC: New, dual-action imidazoquinolinone dimer; inhibits tumor growth, low inflammation/toxicity.</p>Formula:C35H33N5O3Purity:98%Color and Shape:SolidMolecular weight:571.67CGA-JK3
CAS:<p>CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.</p>Formula:C15H19NO3Purity:98%Color and Shape:SolidMolecular weight:261.32PK68
CAS:<p>PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.</p>Formula:C22H24N4O3SPurity:98.09% - 99.64%Color and Shape:SolidMolecular weight:424.52IRAK inhibitor 3
CAS:<p>IRAK inhibitor 3 is an interleukin-1 (IL-1) receptor-associated kinase (IRAK) modulator.</p>Formula:C21H21N5O4SPurity:98.86%Color and Shape:SolidMolecular weight:439.49IMD-vanillin
CAS:<p>IMD-vanillin is a novel compound characterized as an imidazoquinolinone-derived dimer with NF-κB immunomodulatory properties.</p>Formula:C37H45N7O4Purity:98%Color and Shape:SolidMolecular weight:651.8TBK1-IN-1
CAS:<p>TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.</p>Formula:C27H37N7O2Purity:>99.99%Color and Shape:SolidMolecular weight:491.63
