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IκB/IKK

IκB/IKK

The IκB/IKK complex is a key regulator of the NF-κB signaling pathway, which controls the expression of genes involved in immune responses, inflammation, and cell survival. IκB proteins inhibit NF-κB activity by sequestering it in the cytoplasm, while IKKs phosphorylate IκB, leading to its degradation and the activation of NF-κB. Dysregulation of the IκB/IKK pathway is linked to chronic inflammation, cancer, and autoimmune diseases. At CymitQuimica, we provide a selection of high-quality IκB/IKK modulators to support your research in signal transduction, inflammation, and therapeutic development.

Found 61 products of "IκB/IKK"

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  • (Rac)-BAY-985
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    (Rac)-BAY-985

    CAS:
    <p>(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.</p>
    Formula:C27H30F3N9O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:553.58

    Ref: TM-T12659

  • Bay 65-1942 (R form)
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    Bay 65-1942 (R form)

    CAS:
    <p>Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.</p>
    Formula:C22H25N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:395.45

    Ref: TM-T10472

  • ACHP Hydrochloride
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    ACHP Hydrochloride

    CAS:
    <p>ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.</p>
    Formula:C21H25ClN4O2
    Purity:99.83%
    Color and Shape:Solid
    Molecular weight:400.9

    Ref: TM-T10237

  • IKK-IN-4
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    IKK-IN-4

    CAS:
    <p>IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].</p>
    Formula:C18H19N5S
    Color and Shape:Solid
    Molecular weight:337.44

    Ref: TM-T61059

  • TBK1-IN-1
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    TBK1-IN-1

    CAS:
    <p>TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.</p>
    Formula:C27H37N7O2
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:491.63

    Ref: TM-T73322

  • PF-184
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    PF-184

    <p>PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma &amp; COPD research. IC50: 37 nM.</p>
    Formula:C32H32ClFN6O4
    Color and Shape:Solid
    Molecular weight:619.09

    Ref: TM-T73470

  • Glabrescone C
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    Glabrescone C

    CAS:
    <p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>
    Formula:C19H22O7
    Color and Shape:Solid
    Molecular weight:362.37

    Ref: TM-T72899

  • CymitQuimica logo
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    Anti-inflammatory agent 6

    <p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>
    Formula:C22H20O12
    Color and Shape:Solid
    Molecular weight:476.39

    Ref: TM-T63107

  • TBK1/IKKε-IN-1
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    TBK1/IKKε-IN-1

    CAS:
    <p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of &lt;100 nM).</p>
    Formula:C28H26N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.53

    Ref: TM-T13097

  • GTCpFE
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    GTCpFE

    CAS:
    <p>GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.</p>
    Formula:C22H20O8
    Color and Shape:Solid
    Molecular weight:412.39

    Ref: TM-T200141

  • BMS-066
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    BMS-066

    CAS:
    <p>BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.</p>
    Formula:C19H21N7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:379.42

    Ref: TM-T14669