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TLR

TLR

Toll-like receptors (TLRs) are a class of proteins that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and initiating immune responses. TLRs are involved in detecting a wide range of pathogens, including bacteria, viruses, and fungi, and are essential for the activation of inflammatory signaling pathways. Dysregulation of TLR signaling is associated with chronic inflammatory diseases, autoimmune disorders, and cancer. At CymitQuimica, we offer a variety of high-quality TLR modulators to support your research in innate immunity, inflammation, and infectious disease.

Found 66 products of "TLR"

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  • CU-CPD107
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    CU-CPD107

    CAS:
    <p>CU-CPD107 selectively activates TLR8 and ssRNA, inhibits TLR8 with R848 (IC50=13.7 μM), and coactivates with ssRNA.</p>
    Formula:C16H21IN2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:400.25

    Ref: TM-T35349

  • TLR7 agonist 28
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    TLR7 agonist 28

    CAS:
    <p>TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.</p>
    Formula:C26H25N9O7
    Color and Shape:Solid
    Molecular weight:575.533

    Ref: TM-T204940

  • Creatine ethyl ester
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    Creatine ethyl ester

    CAS:
    <p>Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.</p>
    Formula:C6H13N3O2
    Color and Shape:Solid
    Molecular weight:159.186

    Ref: TM-T206807

  • SARM1-IN-4
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    SARM1-IN-4

    CAS:
    <p>SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.</p>
    Formula:C13H17F2N3O2
    Color and Shape:Solid
    Molecular weight:285.29

    Ref: TM-T206825

  • LHC-165
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    LHC-165

    CAS:
    <p>LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.</p>
    Formula:C29H32F2N3O7P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:603.55

    Ref: TM-T15751

  • TLR7/8/9 antagonist 2
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    TLR7/8/9 antagonist 2

    CAS:
    <p>TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.</p>
    Formula:C23H31N7
    Purity:98%
    Color and Shape:Soild
    Molecular weight:405.54

    Ref: TM-T72035

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    Discontinued
    Discontinued product