MNK
MNKs are a group of kinases that interact with MAPKs, particularly ERK and p38, to regulate protein synthesis by phosphorylating the eukaryotic initiation factor 4E (eIF4E). MNK signaling plays a role in cellular stress responses, inflammation, and cancer progression. Targeting MNKs is an emerging strategy in cancer therapy and anti-inflammatory treatments. At CymitQuimica, we provide a selection of MNK inhibitors and modulators to support your research in protein synthesis regulation, oncology, and inflammation.
Found 14 products of "MNK"
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ETC-206
CAS:<p>ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).</p>Formula:C25H20N4O2Purity:99.72% - 99.79%Color and Shape:SolidMolecular weight:408.45NUCC-0200808
<p>NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.</p>Color and Shape:Odour SolidQL-X-138 HCl
<p>QL-X-138 HCl is a BTK/MNK dual kinase inhibitor with anticancer activity and anti-dengue virus 2 activity that inhibits BTK, MNK1, and MNK2 kinases.</p>Formula:C25H20ClN5O2Purity:99.25%Color and Shape:SoildMolecular weight:457.91MNK-IN-4
<p>MNK-IN-4 (compound D25) is a potent and selective MNK inhibitor used in treating acute spleen injury related to sepsis.</p>Formula:C15H17N5Molecular weight:267.1484HSND80
<p>HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.</p>Color and Shape:Odour SolidTomivosertib HCl
CAS:<p>Tomivosertib (eFT508) is a MNK1/2 inhibitor that blocks eIF4E phosphorylation, hindering tumor growth and immune signaling.</p>Formula:C17H21ClN6O2Color and Shape:SolidMolecular weight:376.845Tomivosertib
CAS:<p>Tomivosertib (eFT508) is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM.</p>Formula:C17H20N6O2Purity:97.34% - 99.72%Color and Shape:SolidMolecular weight:340.38CGP 57380
CAS:<p>CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like</p>Formula:C11H9FN6Purity:98.49%Color and Shape:SolidMolecular weight:244.23SLV-2436
CAS:<p>SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).</p>Formula:C19H15ClN4OPurity:98.56%Color and Shape:SolidMolecular weight:350.8HG-10-102-01
CAS:<p>HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).</p>Formula:C17H20ClN5O3Purity:99.59%Color and Shape:SolidMolecular weight:377.83ETC-168
CAS:<p>ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].</p>Formula:C24H19N5O2Color and Shape:SolidMolecular weight:409.44MNK1/2-IN-5
CAS:<p>MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.</p>Formula:C17H16N4O2Purity:98.04%Color and Shape:SolidMolecular weight:308.33DS12881479
CAS:<p>DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].</p>Formula:C16H19N3OSPurity:99.85%Color and Shape:SolidMolecular weight:301.41MNK inhibitor 9
CAS:<p>MNK inhibitor 9 potently blocks MNK1/2 (IC50: 0.003 µM each), is cell-permeable, and useful for tumor research.</p>Formula:C25H29N9OColor and Shape:SolidMolecular weight:471.56
