MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 892 products of "MAPK"
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BI-2852
CAS:BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.Formula:C31H28N6O2Purity:97.77%Color and Shape:SolidMolecular weight:516.59Ref: TM-T10533
1mg110.00€5mg261.00€10mg389.00€25mg643.00€50mg888.00€100mg1,224.00€1mL*10mM (DMSO)298.00€RMC-0331
CAS:RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.Formula:C22H25ClF3N5O3Purity:97.84%Color and Shape:SolidMolecular weight:499.91Ref: TM-T38170
1mg87.00€5mg212.00€10mg379.00€25mg780.00€50mg1,206.00€100mg1,795.00€200mg2,422.00€1mL*10mM (DMSO)226.00€NMDAR/TRPM4-IN-2
CAS:Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.Formula:C11H19BrCl2N2Purity:99.75%Color and Shape:SolidMolecular weight:330.092GSK2008607
CAS:GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.
Formula:C31H28F3N7O3S2Purity:99.36%Color and Shape:SolidMolecular weight:667.72Ref: TM-T27454
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€KRAS G12C inhibitor 25
CAS:KRAS G12C inhibitor 25 blocks SOS1-mediated GDP/GTP swap in KRAS-G12C mutants; IC50: 0.48 nM (WO2021216770A1, comp. 3).Formula:C32H41N7O2Color and Shape:SolidMolecular weight:555.71Laxiflorin B
CAS:Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].Formula:C20H24O5Purity:98%Color and Shape:SolidMolecular weight:344.4XRP44X
CAS:XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.Formula:C21H21ClN4OPurity:99.67%Color and Shape:SolidMolecular weight:380.87HPK1-IN-33
CAS:HPK1-IN-33 inhibits HPK1 with 1.7 nM potency, reduces IL-2 in Jurkat cells with 286 nM EC50, and is less effective in HPK1 KO cells.Formula:C18H16ClFN6Color and Shape:SolidMolecular weight:370.81KRAS G12C inhibitor 53
CAS:KRAS G12C inhibitor 53 (Compound 1) is a KRAS G12C inhibitor.Formula:C21H14ClF2N5O2Color and Shape:SolidMolecular weight:441.82HPK1-IN-11
CAS:HPK1-IN-11 is a potent HPK1 inhibitor. HPK1-IN-11 has potential for the study of HPK1-related diseases.Formula:C27H25N5O2Color and Shape:SolidMolecular weight:451.52FGTI-2734 mesylate (1247018-19-4 free base)
CAS:FGTI-2734 mesylate hinders KRAS, overcoming resistance and targeting pancreatic tumors; inhibits FT and GGT with IC50s of 250 nM, 520 nM.Formula:C27H35FN6O5S2Purity:98%Color and Shape:SolidMolecular weight:606.73KRAS G12C inhibitor 32
CAS:KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].Formula:C29H30Cl3FN6O3Purity:98%Color and Shape:SolidMolecular weight:635.94AZ-TAK1
CAS:"AZ-Tak1 inhibits TAK1 kinase (IC50=0.009mM), reduces p38/ERK levels, and induces apoptosis in Mino, SP53, Jeko cells with increasing efficacy at 0.1-0.5mM."Formula:C25H28FN7O2Color and Shape:SolidMolecular weight:477.53RGB-1
CAS:RGB-1 is a small molecule that stabilizes the RNA G-quadruplex structure and enhances G-quadruplex-mediated RNA translation inhibition.Formula:C22H12N4O4S2Purity:98.07%Color and Shape:SolidMolecular weight:460.49HPK1-IN-13
CAS:HPK1-IN-13 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.Formula:C25H24FN5O2Color and Shape:SolidMolecular weight:445.49Glecirasib
CAS:Glecirasib (JAB-21822,KRAS G12C inhibitor 36) is an orally active KRAS G12C inhibitor that selectively binds to and inhibits KRAS G12C-dependent signalingFormula:C31H26ClF4N7O2Purity:99.7% - >99.99%Color and Shape:SolidMolecular weight:640.03AMG-548 hydrochloride (864249-60-5 free base)
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selectiveFormula:C29H28ClN5OPurity:98%Color and Shape:SolidMolecular weight:498.02ERK Inhibitor II (Negative control)
CAS:ERK Inhibitor II, a control, blocks ERK and insulin receptor activation, aiding diabetes research.Formula:C18H12N6OColor and Shape:SolidMolecular weight:328.33KRAS G12C inhibitor 30
CAS:KRAS G12C inhibitor 30 is an inhibitor of KRAS G12C and can be used to study cancer.Formula:C25H22ClFN6O3Color and Shape:SolidMolecular weight:508.93Pan-RAF kinase inhibitor 1
CAS:Potent Pan-RAF inhibitor 1 targets RAF/MAPK pathway, curbing RAS-mutated cancer cell growth. (Patent WO2021110141A1, compound 16B)Formula:C26H24F3N3O4Color and Shape:SolidMolecular weight:499.48HPK1-IN-35
CAS:HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM.Formula:C30H32N8O3SColor and Shape:SolidMolecular weight:584.69MNK inhibitor 9
CAS:MNK inhibitor 9 potently blocks MNK1/2 (IC50: 0.003 µM each), is cell-permeable, and useful for tumor research.Formula:C25H29N9OColor and Shape:SolidMolecular weight:471.56SOS1 agonist-1
CAS:SOS1 agonist-1 (compound 79) serves as an agonist for the Son of sevenless homologue 1 (SOS1), a crucial guanine nucleotide exchange factor involved in catalyzing the GDP to GTP exchange on RAS proteins, thus regulating RAS activation. By increasing nucleotide exchange on RAS, SOS1 agonists enhance cellular RAS-GTP levels and induce biphasic signaling alterations in ERK1/2 phosphorylation, playing a pivotal role in anti-cancer activity [1].Formula:C26H29BrClFN4O2Color and Shape:SolidMolecular weight:563.89B-Raf IN 16
CAS:B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Formula:C20H19N5O3SPurity:99.31% - 99.78%Color and Shape:SolidMolecular weight:409.46ERK1/2 inhibitor 9
CAS:ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates theFormula:C31H32ClN7O3Purity:98%Color and Shape:SolidMolecular weight:586.08RPR203494
CAS:RPR203494 is a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency.Formula:C26H29FN6O4Color and Shape:SolidMolecular weight:508.54HPK1-IN-37
CAS:HPK1-IN-37 (compound A85), with an IC50 value of 3.7 nM, is a potent inhibitor of HPK1.Formula:C27H35N7O4Color and Shape:SolidMolecular weight:521.61Rac1-IN-3
CAS:Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].Formula:C21H23N7O2Purity:98%Color and Shape:SolidMolecular weight:405.45PROTAC KRAS G12C degrader-3
CAS:PROTAC KRAS G12C Degrader-3 (Comp 283) serves as a potent degrader of KRAS G12C, utilized in cancer research [1].Formula:C63H75ClN14O6Purity:98%Color and Shape:SolidMolecular weight:1159.81BI-0474
CAS:BI-0474: KRASG12C inhibitor, IC50=7.0 nM, blocks GDP-KRAS/SOS1, anti-tumor in NCI-H358 cells & lung cancer model, for cancer research.Formula:C30H37N9O2SPurity:99.96%Color and Shape:SolidMolecular weight:587.74ARS-1323-alkyne
CAS:ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.Formula:C28H27ClF2N6O3Purity:98.00% - 99%Color and Shape:SolidMolecular weight:569AZD4747
CAS:AZD4747 is an inhibitor of the mutant GTPase KRASG12C that hasial antitumor activity for the study of pancreatic and colorectal adenocarcinoma.Formula:C24H22ClFN2O3Purity:99.36%Color and Shape:SolidMolecular weight:440.89Ref: TM-T79213
1mg205.00€5mg537.00€10mg858.00€25mg1,251.00€50mg1,639.00€100mg2,277.00€1mL*10mM (DMSO)520.00€(R)-VX-11e
CAS:(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.Formula:C24H20Cl2FN5O2Purity:98.73%Color and Shape:SolidMolecular weight:500.35KRAS G12C inhibitor 17
CAS:KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.Formula:C24H20ClF2N3O3Purity:98%Color and Shape:SolidMolecular weight:471.88DL-threo dihydrosphingosine
CAS:DL-threo dihydrosphingosine blocks ERK, inhibits smooth muscle proliferation, and works against growth factor/G-protein ERK activation.Formula:C18H39NO2Color and Shape:SolidMolecular weight:301.51Inflachromene
CAS:Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene is used in the study of epilepsy.Formula:C21H19N3O4Purity:97.36% - 99.88%Color and Shape:SolidMolecular weight:377.39Ref: TM-T24167
1mg109.00€5mg260.00€10mg416.00€25mg710.00€50mg973.00€100mg1,314.00€1mL*10mM (DMSO)286.00€HPK1-IN-9
CAS:HPK1-IN-9: Potent MAP4K family kinase inhibitor targeting hematopoietic progenitor cells; potential in HPK1 diseases. (Patent WO2021213317A1)Formula:C30H33N7O2Color and Shape:SolidMolecular weight:523.63ERK1/2 inhibitor 8
CAS:ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).Formula:C23H20ClN7O2SColor and Shape:SolidMolecular weight:493.97Org OD 02-0
CAS:10-Ethenyl-19-norprogesterone (Org OD 02-0) is a selective agonist for the membrane progesterone receptor α (mPRα) with an IC50 of 33.9 nM, known to activateFormula:C22H30O2Purity:98%Color and Shape:SolidMolecular weight:326.47KRAS G12C inhibitor 61
CAS:KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.Formula:C31H33ClFN7O2Purity:98%Color and Shape:SolidMolecular weight:590.09Deltasonamide 1
CAS:Deltasonamide is a potent and selective inhibitor of PDE6δ‐KRas.Formula:C30H39ClN6O4S2Color and Shape:SolidMolecular weight:647.25L 731734
CAS:L 731734 is a farnesyltransferase inhibitor.Formula:C19H38N4O3SColor and Shape:SolidMolecular weight:402.6(aS)-PH-797804
CAS:(aS)-PH-797804 is a selective inhibitor of p38 MAPK, demonstrating inhibitory concentration (IC50) values of 26 nM for p38α and 102 nM for p38β. This compound exhibits anti-inflammatory activity [1] [2].Formula:C22H19BrF2N2O3Color and Shape:SolidMolecular weight:477.3KRas G12C inhibitor 1
CAS:KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.Formula:C31H38N6O3Purity:98%Color and Shape:SolidMolecular weight:542.67MS934
CAS:MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM.Formula:C52H69F3IN7O6SPurity:98%Color and Shape:SolidMolecular weight:1104.11SOS1/KRAS-IN-1
CAS:SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].Formula:C24H26F3N5OPurity:98%Color and Shape:SolidMolecular weight:457.49TNIK&MAP4K4-IN-1
CAS:TNIK&MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor targeting TNIK and MAP4K4/HGK, exhibiting IC50 values of 1.29 nM and <10 nM, respectively, in humanFormula:C25H23FN4O3Color and Shape:SolidMolecular weight:446.47(R)-BDP9066
CAS:(R)-BDP9066 blocks MRCK to curb cancer cell spread, aiding research on diseases like cancer.Formula:C20H24N6Color and Shape:SolidMolecular weight:348.44KRAS G12C inhibitor 34
CAS:KRAS G12C inhibitor 34 is an inhibitor of KRAS G12C that can be used to study cancer research.Formula:C32H32ClN5O3Color and Shape:SolidMolecular weight:570.08TH-Z827
CAS:TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).Formula:C30H38N6OPurity:98%Color and Shape:SolidMolecular weight:498.66KRAS G12C inhibitor 59
CAS:KRAS G12C Inhibitor 59 is a compound with anticancer properties.Formula:C32H39F6N7O5Purity:98%Color and Shape:SolidMolecular weight:715.69KRAS G12C inhibitor 13
CAS:KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .Formula:C40H46F3N7O4Purity:98%Color and Shape:SolidMolecular weight:745.83KRAS G12C inhibitor 5
CAS:KRAS G12C inhibitor 5 is a KRas G12C inhibitor.Formula:C32H37N7O2Purity:98%Color and Shape:SolidMolecular weight:551.68pan-KRAS-IN-4
CAS:Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].Formula:C36H34F2N6O3Purity:98%Color and Shape:SolidMolecular weight:636.69TC13172
CAS:TC13172 is a potent, covalent MLKL inhibitor, selective over RIPK1/RIPK3. It blocks TSZ-induced necroptosis (EC50=2nM) and MLKL oligomerization at 100nM.Formula:C17H16N4O5SPurity:98%Color and Shape:SolidMolecular weight:388.4KRAS G12C inhibitor 51
CAS:KRAS G12C inhibitor 51 is a KRAS G12C inhibitor.Formula:C33H35FN6O3Color and Shape:SolidMolecular weight:582.67KRAS G12D modulator-1
CAS:KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and isFormula:C30H36FN5O4Purity:98%Color and Shape:SolidMolecular weight:549.64ARS-1323
CAS:ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.Formula:C21H17ClF2N4O2Purity:99.53%Color and Shape:SolidMolecular weight:430.84Ref: TM-T10375
2mg38.00€5mg56.00€10mg94.00€25mg129.00€50mg168.00€100mg235.00€200mg350.00€1mL*10mM (DMSO)63.00€RO4927350
CAS:RO4927350 is a potent, selective MEK1/2 inhibitor, blocking MAPK pathway in vitro/vivo and showing notable antitumor effects.Formula:C27H28N4O6SColor and Shape:SolidMolecular weight:536.6GNE 220 hydrochloride
CAS:GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).Formula:C25H27ClN8Color and Shape:SolidMolecular weight:474.99B-Raf IN 15
CAS:B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Formula:C19H15N3OSPurity:98%Color and Shape:SolidMolecular weight:333.41KRAS G12C inhibitor 41
CAS:KRAS G12C inhibitor 41 targets a key signaling protein, potentially aiding cancer research.Formula:C36H37ClFN9O2Color and Shape:SolidMolecular weight:682.19SKF-86002 dihydrochloride
CAS:p38 MAP kinase inhibitorFormula:C16H14Cl2FN3SPurity:98%Color and Shape:SolidMolecular weight:370.27B-Raf IN 5
CAS:B-Raf IN 5 is a potent inhibitor of the protein kinase B-Raf (IC50: 2.0 nM). B-Raf IN 5 resists rapid metabolism and does not bind to the secondary target PXR.Formula:C23H18ClF3N6O3S2Color and Shape:SolidMolecular weight:583.01KRAS G12C inhibitor 49
CAS:KRAS G12C inhibitor 49 is an orally active KRAS G12C inhibitor that exhibits antitumour effects.Formula:C31H31ClN6O3Color and Shape:SolidMolecular weight:571.07SHP2-IN-22
CAS:SHP2-IN-22, a potent SHP2 allosteric inhibitor, exhibits an IC50 value of 17.7 nM and effectively suppresses proliferation, migration, and invasion in MIA PaCa-Formula:C23H22Cl2N8OColor and Shape:SolidMolecular weight:497.38SOS1-IN-5
CAS:SOS1-IN-5, a potent pyrimidine inhibitor, disrupts RAS-SOS1, blocking KRAS activation.
Formula:C26H31F3N4O5Color and Shape:SolidMolecular weight:536.54CHI-000-667
CAS:CHI-000-667 can be used in studies about Ras.Formula:C21H16ClNO4SColor and Shape:SolidMolecular weight:413.87KRAS G12C inhibitor 28
CAS:KRAS G12C Inhibitor 28 is a compound that effectively inhibits the KRAS G12C mutation, exhibiting potent antitumor effects with an inhibitory concentration (Formula:C33H36F2N5O4PColor and Shape:SolidMolecular weight:635.64KRAS inhibitor-12
CAS:KRAS inhibitor-12 blocks KRAS G12C (IC50: 0.537 μM) and p-ERK in cancer cells; promising for pancreatic, colorectal, lung cancer study.Formula:C19H16Cl2FN5OSColor and Shape:SolidMolecular weight:452.33Ras inhibitor 134
CAS:Ras inhibitor 134 can be used in studies about Ras.Formula:C23H21ClFN5O3Color and Shape:SoildMolecular weight:469.9ARQ-736
CAS:ARQ 736 effectively targets and inhibits BRAF, crucial in MAPK pathway, beneficial for treating melanomas and certain colon cancers.Formula:C25H25N8Na2O8PSColor and Shape:SolidMolecular weight:674.54DT-061
CAS:DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.Formula:C25H23F3N2O5SPurity:98%Color and Shape:SolidMolecular weight:520.52KRAS G12C inhibitor 40
CAS:KRAS G12C inhibitor 40 targets KRAS G12C in cancer research (WO2021129824A1, compound 70).Formula:C34H36ClFN10O2Color and Shape:SolidMolecular weight:671.17p38 Kinase inhibitor 4
CAS:Compound 135, also known as p38 Kinase Inhibitor 4, is a potent inhibitor of p38 [1].Formula:C12H9Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:282.13Kras binder 12
CAS:Kras binder 12 can be used in studies about Ras.Formula:C29H47N9O6Color and Shape:SoildMolecular weight:617.74KRAS degrader-1
CAS:KRAS degrader-1 (compound 1) is a potent agent that selectively targets KRAS proteins for destruction via the autophagy-lysosomal degradation pathway [1].Formula:C55H57Br2ClFIN8O7Color and Shape:SolidMolecular weight:1283.25KRAS inhibitor FB9
CAS:KRAS inhibitor FB9 can be used in studies about Ras.Formula:C23H21ClF4N2O5Color and Shape:SolidMolecular weight:516.87K-Ras G12C-IN-2
CAS:K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.Formula:C21H27ClN4O3Purity:98%Color and Shape:SolidMolecular weight:418.92KRAS G12C inhibitor 14
CAS:KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].Formula:C24H19ClF2N4O3Purity:98%Color and Shape:SolidMolecular weight:484.88KRAS G12D mutation regulator 4
CAS:KRAS G12D mutation regulator 4 can be used in studies about Ras.Formula:C33H33FN6O2Color and Shape:SolidMolecular weight:564.65JNK3 inhibitor-1
CAS:JNK3 inhibitor-1: potent, selective, IC50 of 0.005 μM, orally bioavailable, brain-penetrant.Formula:C21H17ClFN5O2SColor and Shape:SolidMolecular weight:457.91HPK1-IN-10
CAS:HPK1-IN-10 inhibits HPK1, a MAP4K kinase from progenitor cells, with potential in treating HPK1 diseases, detailed in patent WO2021213317A1.Formula:C31H34N6O2Color and Shape:SolidMolecular weight:522.64pan-KRAS-IN-2
CAS:Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12DFormula:C34H34F2N4O3Purity:98%Color and Shape:SolidMolecular weight:584.66SOS1-IN-7
CAS:SOS1-IN-7 (compound 18-p1) is a potent inhibitor of SOS1 and acts on SOS1-G12D (IC50: 20 nM) and SOS1-G12V (IC50: 67 nM).Formula:C23H25F3N4O3Color and Shape:SolidMolecular weight:462.46KRAS G12C mutant protein inhibitor A-1
CAS:KRAS G12C mutant protein inhibitor A-1 can be used in studies about Ras.Formula:C31H26ClF4N7O2Color and Shape:SolidMolecular weight:640.03KRAS G12C inhibitor 16
CAS:KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.Formula:C24H21ClFN3O3Purity:97.84%Color and Shape:SolidMolecular weight:453.89K-Ras G12C-IN-1
CAS:K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.Formula:C22H23Cl2N3O3Color and Shape:SolidMolecular weight:448.34SOS1-IN-8
CAS:SOS1-IN-8 is an inhibitor of SOS1 and acts on SOS1-G12D (IC50: 11.6 nM) and SOS1-G12V (IC50: 40.7 nM).Formula:C24H26F3N3O4Color and Shape:SolidMolecular weight:477.48HPK1-IN-27
CAS:HPK1-IN-27 inhibits HPK1 (MAP4K1), a kinase with potential for cancer treatment, per patent WO2019016071A1, compound 38.Formula:C26H23F3N4O4Color and Shape:SolidMolecular weight:512.48Cobimetinib racemate
CAS:Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activatedFormula:C21H21F3IN3O2Purity:98.00% - 99.71%Color and Shape:SolidMolecular weight:531.31ZG1077
CAS:ZG1077, a covalent KRAS G12C inhibitor, is utilized in non-small cell lung cancer (NSCLC) research.Formula:C33H33F2N5O5SColor and Shape:SolidMolecular weight:649.71GNE 220
CAS:GNE-220 is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).Formula:C25H26N8Purity:98%Color and Shape:SolidMolecular weight:438.53pan-KRAS-IN-3
CAS:Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Formula:C33H32F3N5O2Purity:98%Color and Shape:SolidMolecular weight:587.63SB 203580 sulfone
CAS:SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 μM for IL-1 inhibition and 0.03 μM for CSBP-mediated signaling inhibition [1].Formula:C21H16FN3O2SColor and Shape:SolidMolecular weight:393.43SOS1-IN-4
CAS:SOS1-IN-4 is a potent inhibitor of SOS1 (IC50: 56 nM) and can be used in the study of KRAS-C12C/SOS1 interactions.Formula:C24H29F2N4O2PColor and Shape:SolidMolecular weight:474.48JNK3 inhibitor-3
CAS:JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Formula:C26H25N7O2Purity:98%Color and Shape:SolidMolecular weight:467.52KRAS G12C inhibitor 35
CAS:KRAS G12C inhibitor 35 targets KRAS G12C in cancer research (CN112920183A, compound 3).Formula:C31H27ClF2N6O3Color and Shape:SolidMolecular weight:605.03MEK-IN-6 hydrate
CAS:MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].Formula:C18H22FN3O5SPurity:98%Color and Shape:SolidMolecular weight:411.45AMG-548 dihydrochloride (864249-60-5 free base)
AMG-548 dihydrochloride: oral p38α inhibitor, Ki: 0.5 nM; less so for p38β, Ki: 36 nM; >> p38γ/δ; blocks LPS-induced TNFα, IC50: 3 nM.Formula:C29H29Cl2N5OPurity:98%Color and Shape:SolidMolecular weight:534.48
