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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 881 products of "MAPK"

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  • PLX7904
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    PLX7904

    CAS:
    <p>PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.</p>
    Formula:C24H22F2N6O3S
    Purity:99.51% - 99.66%
    Color and Shape:Solid
    Molecular weight:512.53

    Ref: TM-T6949

  • Sulindac sulfide
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    Sulindac sulfide

    CAS:
    <p>Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.</p>
    Formula:C20H17FO2S
    Purity:99.35%
    Color and Shape:Solid
    Molecular weight:340.41

    Ref: TM-T13037

  • HCI-2184
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    HCI-2184

    CAS:
    <p>HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.</p>
    Formula:C23H28ClN7O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:502.03

    Ref: TM-T24130

  • BRAF inhibitor
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    BRAF inhibitor

    CAS:
    <p>BRAF inhibitor is an inhibitor of B-Raf.</p>
    Formula:C22H18F2N4O3S
    Purity:98.2% - 98.41%
    Color and Shape:Solid
    Molecular weight:456.47

    Ref: TM-T10599

  • ERK1/2 inhibitor 1
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    ERK1/2 inhibitor 1

    CAS:
    <p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>
    Formula:C29H32ClN5O4
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:550.05

    Ref: TM-T11226

  • PF-05381941
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    PF-05381941

    CAS:
    <p>PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.</p>
    Formula:C27H26N6O2
    Purity:98.04%
    Color and Shape:Solid
    Molecular weight:466.53

    Ref: TM-T36017

  • MEK-IN-1
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    MEK-IN-1

    CAS:
    <p>MEK-IN-1 is a MEK inhibitor.</p>
    Formula:C24H20N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:428.44

    Ref: TM-T10675

  • PAF (C16)
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    PAF (C16)

    CAS:
    <p>PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability.</p>
    Formula:C26H54NO7P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:523.68

    Ref: TM-T21547

  • B-Raf IN 13
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    B-Raf IN 13

    CAS:
    <p>B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.</p>
    Formula:C19H19ClFN3O4S
    Purity:99.41% - >99.99%
    Color and Shape:Soild
    Molecular weight:439.89

    Ref: TM-T67862

  • KRAS G12D inhibitor 10
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    KRAS G12D inhibitor 10

    CAS:
    <p>KRAS G12D inhibitor 10 targets KRAS G12D in cancer research (WO2021108683A1, compound 34).</p>
    Formula:C33H41ClN8O2
    Color and Shape:Solid
    Molecular weight:617.18

    Ref: TM-T72345

  • GGTI-286
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    GGTI-286

    CAS:
    <p>GGTI-286: GGTase I inhibitor, cell-permeable, IC50=2μM. Strongly blocks Rap1A geranylation; less effective on H-Ras, Ras4B IC50=1μM.</p>
    Formula:C23H31N3O3S
    Color and Shape:Solid
    Molecular weight:429.58

    Ref: TM-T62379

  • MCP110
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    MCP110

    CAS:
    <p>MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.</p>
    Formula:C33H36N2O3
    Purity:97.23%
    Color and Shape:Oil
    Molecular weight:508.65

    Ref: TM-T24437

  • KYA1797
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    KYA1797

    CAS:
    <p>KYA1797 inhibits Wnt/ß-catenin, targeting axin, and promotes ß-catenin/Ras decay, halting APC/KRAS mutant CRC growth.</p>
    Formula:C17H12N2O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:404.42

    Ref: TM-T27760

  • RSK2-IN-2
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    RSK2-IN-2

    CAS:
    <p>RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 ( RSK2 ) kinase which also inhibits MSK1, MSK2, and RSK3 [1].</p>
    Formula:C16H11N5O
    Color and Shape:Solid
    Molecular weight:289.29

    Ref: TM-T60585

  • GABAB receptor antagonist 1
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    GABAB receptor antagonist 1

    CAS:
    (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selective
    Formula:C18H24O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:304.38

    Ref: TM-T11350

  • B-Raf IN 8
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    B-Raf IN 8

    CAS:
    <p>B-Raf IN 8: strong B-Raf inhibitor (70.65 nM IC50); combats liver, colon, breast &amp; prostate cancer with IC50s from 9.78 to 29.85 μM.</p>
    Formula:C18H17N3O2
    Color and Shape:Solid
    Molecular weight:307.35

    Ref: TM-T60727

  • HPK1-IN-24
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    HPK1-IN-24

    CAS:
    <p>HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].</p>
    Formula:C19H14FN5
    Color and Shape:Solid
    Molecular weight:331.35

    Ref: TM-T60973

  • UC-857993
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    UC-857993

    CAS:
    <p>UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.</p>
    Formula:C25H22ClNO2
    Color and Shape:Solid
    Molecular weight:403.9

    Ref: TM-T69195

  • JNK3 inhibitor-2
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    JNK3 inhibitor-2

    CAS:
    <p>JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (&gt;100 μM); targets DDR1 and EGFR mutations.</p>
    Formula:C20H14N2O2
    Color and Shape:Solid
    Molecular weight:314.34

    Ref: TM-T60805

  • Tpl2 Kinase Inhibitor 1
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    Tpl2 Kinase Inhibitor 1

    CAS:
    <p>Tpl2 Kinase Inhibitor 1 is an effective and selective Tpl2 inhibitor.</p>
    Formula:C21H14ClFN6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:404.83

    Ref: TM-T17145