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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 885 products of "MAPK"

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  • JNK-1-IN-1
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    JNK-1-IN-1

    CAS:
    <p>JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.</p>
    Formula:C24H22N6S
    Color and Shape:Solid
    Molecular weight:426.54

    Ref: TM-T73109

  • ADTL-EI1712
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    ADTL-EI1712

    CAS:
    <p>ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.</p>
    Formula:C22H18Cl2N4O2S2
    Color and Shape:Solid
    Molecular weight:505.44

    Ref: TM-T38377

  • JX 401
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    JX 401

    CAS:
    <p>JX 401 is a p38α inhibitor.</p>
    Formula:C21H25NO2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:355.49

    Ref: TM-T22885

  • SB 204900
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    SB 204900

    CAS:
    <p>SB 204900 inhibit the release of histamine and TNF-α from RBL-2H3 cells.</p>
    Formula:C18H17NO2
    Color and Shape:Solid
    Molecular weight:279.33

    Ref: TM-T28671

  • HPK1-IN-29
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    HPK1-IN-29

    CAS:
    <p>"HPK1-IN-29 suppresses HPK1, boosting anti-tumor immunity; potential for immune disease research."</p>
    Formula:C26H18F3N5O2
    Color and Shape:Solid
    Molecular weight:489.45

    Ref: TM-T63270

  • DDO3711
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    DDO3711

    CAS:
    <p>"DDO3711, a PHORC, links an ASK1 inhibitor to a PP5 activator, inhibiting ASK1 (IC50=164.1 nM), dephosphorylating p-ASK1, and showing anti-cancer potential."</p>
    Formula:C42H41N9O6
    Color and Shape:Solid
    Molecular weight:767.83

    Ref: TM-T73460

  • KRAS G12C inhibitor 29
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    KRAS G12C inhibitor 29

    CAS:
    <p>KRAS G12C inhibitor 29 is an inhibitor of KRAS G12C and can be used to study cancer.</p>
    Formula:C23H21ClFN5O2
    Color and Shape:Solid
    Molecular weight:453.9

    Ref: TM-T62785

  • 8-CPT-2Me-cAMP, sodium salt
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    8-CPT-2Me-cAMP, sodium salt

    CAS:
    <p>8-CPT-2Me-cAMP sodium activates Epac GEFS, targets Rap1/2, has 2.2 μM EC50 for Epac1, doesn't activate PKA, and prompts Ca2+ release in β-cells.</p>
    Formula:C17H16ClN5NaO6PS
    Color and Shape:Solid
    Molecular weight:507.82

    Ref: TM-T22014

  • SCH-53870
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    SCH-53870

    CAS:
    <p>SCH-53870 inhibits p21-hRas nucleotide exchange in vitro.</p>
    Formula:C18H18N2O4S
    Color and Shape:Solid
    Molecular weight:358.41

    Ref: TM-T28733

  • KRAS inhibitor-16
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    KRAS inhibitor-16

    CAS:
    <p>KRAS inhibitor-16 blocks KRAS G12C and p-ERK in cancer cells; potential for pancreatic, colorectal, lung cancer treatment. IC50: 0.457 μM.</p>
    Formula:C20H16Cl2FN3O2S
    Color and Shape:Solid
    Molecular weight:452.33

    Ref: TM-T62752

  • SOS1-IN-12
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    SOS1-IN-12

    CAS:
    <p>SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).</p>
    Formula:C23H26F3N5
    Color and Shape:Solid
    Molecular weight:429.48

    Ref: TM-T62371

  • MTBT
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    MTBT

    CAS:
    <p>MTBT is the proliferation of cancer cells inhibitor. It induces cell cycle arrest and activates p38 MAPK.</p>
    Formula:C14H11NO2S2
    Color and Shape:Solid
    Molecular weight:289.37

    Ref: TM-T24505

  • ARS-2102
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    ARS-2102

    CAS:
    <p>ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .</p>
    Formula:C28H31ClF2N6O2
    Color and Shape:Solid
    Molecular weight:557.03

    Ref: TM-T73396

  • ERK5-IN-4
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    ERK5-IN-4

    CAS:
    <p>ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.</p>
    Formula:C16H11Cl2FN4O2
    Color and Shape:Solid
    Molecular weight:381.19

    Ref: TM-T61628

  • KRAS inhibitor-15
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    KRAS inhibitor-15

    CAS:
    <p>KRAS inhibitor-15 blocks KRAS G12C and p-ERK in cancer cells; potent against pancreatic and lung cancers. IC50: 0.954 μM (KRAS), 2.03/&gt;33.3 μM (p-ERK).</p>
    Formula:C20H17Cl2FN4OS
    Color and Shape:Solid
    Molecular weight:451.34

    Ref: TM-T62737

  • (S)-p38 MAPK Inhibitor III
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    (S)-p38 MAPK Inhibitor III

    CAS:
    <p>(S)-p38 MAPK inhibitor III: a cell-permeable, methylsulfanylimidazole; IC50s: 0.90 µM for p38 MAPK, 0.37 µM TNF-α, 0.044 µM IL-1β.</p>
    Formula:C23H21FN4S
    Color and Shape:Solid
    Molecular weight:404.5

    Ref: TM-T35420

  • (R)-PD 0325901CL
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    (R)-PD 0325901CL

    CAS:
    <p>(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.</p>
    Formula:C16H14ClF2IN2O4
    Color and Shape:Solid
    Molecular weight:498.65

    Ref: TM-T72654

  • RAS inhibitor Abd-7
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    RAS inhibitor Abd-7

    CAS:
    <p>Abd-7: potent RAS inhibitor (Kd=51 nM) that blocks RAS-effector PPI, disrupting KRAS, NRAS Q61H, HRAS G12V signaling.</p>
    Formula:C23H25N3O3
    Color and Shape:Solid
    Molecular weight:391.46

    Ref: TM-T36641

  • RAF-IN-1
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    RAF-IN-1

    CAS:
    <p>RAF-IN-1: strong b/cRAF inhibitor; cRAF IC50=3.8 nM; bRAFwt IC50=36 nM; bRAFV600E IC50=29.4 nM; A375/H358 bRAFV600E GI50=3.4/2.9 nM.</p>
    Formula:C26H22F3N3O4
    Color and Shape:Solid
    Molecular weight:497.47

    Ref: TM-T63365

  • KRAS inhibitor-4
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    KRAS inhibitor-4

    CAS:
    <p>KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor.</p>
    Formula:C30H39ClN8O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:563.14

    Ref: TM-T11772