MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 886 products of "MAPK"
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KRAS G12D mutation regulator 4
CAS:<p>KRAS G12D mutation regulator 4 can be used in studies about Ras.</p>Formula:C33H33FN6O2Color and Shape:SolidMolecular weight:564.65KRAS G12C inhibitor 21
CAS:<p>KRAS G12C inhibitor 21 is a KRAS G12C inhibitor.</p>Formula:C34H30ClN3O4Color and Shape:SolidMolecular weight:580.07CMP3a
CAS:<p>CMP3a, a NEK2 inhibitor, hinders GBM in mice and enhances radiotherapy by disrupting EZH2.</p>Formula:C28H27F3N6O2SColor and Shape:SolidMolecular weight:568.61Ras inhibitor 134
CAS:<p>Ras inhibitor 134 can be used in studies about Ras.</p>Formula:C23H21ClFN5O3Color and Shape:SoildMolecular weight:469.9B-Raf IN 5
CAS:<p>B-Raf IN 5 is a potent inhibitor of the protein kinase B-Raf (IC50: 2.0 nM). B-Raf IN 5 resists rapid metabolism and does not bind to the secondary target PXR.</p>Formula:C23H18ClF3N6O3S2Color and Shape:SolidMolecular weight:583.01HPK1-IN-10
CAS:<p>HPK1-IN-10 inhibits HPK1, a MAP4K kinase from progenitor cells, with potential in treating HPK1 diseases, detailed in patent WO2021213317A1.</p>Formula:C31H34N6O2Color and Shape:SolidMolecular weight:522.64SOS1/KRAS-IN-1
CAS:<p>SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].</p>Formula:C24H26F3N5OPurity:98%Color and Shape:SolidMolecular weight:457.49SOS1-IN-5
CAS:<p>SOS1-IN-5, a potent pyrimidine inhibitor, disrupts RAS-SOS1, blocking KRAS activation.</p>Formula:C26H31F3N4O5Color and Shape:SolidMolecular weight:536.54GNE 220 hydrochloride
CAS:<p>GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).</p>Formula:C25H27ClN8Color and Shape:SolidMolecular weight:474.99KRAS inhibitor-12
CAS:<p>KRAS inhibitor-12 blocks KRAS G12C (IC50: 0.537 μM) and p-ERK in cancer cells; promising for pancreatic, colorectal, lung cancer study.</p>Formula:C19H16Cl2FN5OSColor and Shape:SolidMolecular weight:452.33SKF-86002 dihydrochloride
CAS:<p>p38 MAP kinase inhibitor</p>Formula:C16H14Cl2FN3SPurity:98%Color and Shape:SolidMolecular weight:370.27K-Ras G12C-IN-1
CAS:<p>K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.</p>Formula:C22H23Cl2N3O3Color and Shape:SolidMolecular weight:448.34KRAS G12C inhibitor 25
CAS:<p>KRAS G12C inhibitor 25 blocks SOS1-mediated GDP/GTP swap in KRAS-G12C mutants; IC50: 0.48 nM (WO2021216770A1, comp. 3).</p>Formula:C32H41N7O2Color and Shape:SolidMolecular weight:555.71SOS1-IN-16
CAS:<p>SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 of</p>Formula:C30H31F3N4O3Purity:98%Color and Shape:SolidMolecular weight:552.59HPK1-IN-33
CAS:<p>HPK1-IN-33 inhibits HPK1 with 1.7 nM potency, reduces IL-2 in Jurkat cells with 286 nM EC50, and is less effective in HPK1 KO cells.</p>Formula:C18H16ClFN6Color and Shape:SolidMolecular weight:370.81KRAS G12C inhibitor 53
CAS:<p>KRAS G12C inhibitor 53 (Compound 1) is a KRAS G12C inhibitor.</p>Formula:C21H14ClF2N5O2Color and Shape:SolidMolecular weight:441.82HPK1-IN-11
CAS:<p>HPK1-IN-11 is a potent HPK1 inhibitor. HPK1-IN-11 has potential for the study of HPK1-related diseases.</p>Formula:C27H25N5O2Color and Shape:SolidMolecular weight:451.52pan-KRAS-IN-3
CAS:<p>Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].</p>Formula:C33H32F3N5O2Purity:98%Color and Shape:SolidMolecular weight:587.63SB 203580 sulfone
CAS:<p>SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 μM for IL-1 inhibition and 0.03 μM for CSBP-mediated signaling inhibition [1].</p>Formula:C21H16FN3O2SColor and Shape:SolidMolecular weight:393.43AZ-TAK1
CAS:<p>"AZ-Tak1 inhibits TAK1 kinase (IC50=0.009mM), reduces p38/ERK levels, and induces apoptosis in Mino, SP53, Jeko cells with increasing efficacy at 0.1-0.5mM."</p>Formula:C25H28FN7O2Color and Shape:SolidMolecular weight:477.53
